Results 211 to 220 of about 302,721 (262)

Transcriptome-based screening in TARDBP/TDP-43 knock-in motor neurons identifies the NEDD8-activating enzyme inhibitor MLN4924. [PDF]

open access: yesSci Rep
Lépine S   +15 more
europepmc   +1 more source

Neurons but Motor Neurons in Motor Neuron disease

Italian Journal of Anatomy and Embryology, 2014
The occurrence of motor neuron death is the milestone of amyotrophic lateral sclerosis (ALS). Therefore, morphological analysis along decades focussed on motor neuron loss as the sole marker to score disease severity. Recently, non autonomous cell death took a prominent role to explain the need for additional cell types to induce motor neuron ...
Fornai, Francesco   +8 more
openaire   +1 more source

Motor Neuron Disease

Physical Medicine and Rehabilitation Clinics of North America, 2001
Motor neuron disease refers to a spectrum of disorders resulting from degeneration of the upper or lower motor neurons or both. Amyotrophic lateral sclerosis is the most common form of motor neuron disease, in which patients demonstrate evidence of both anterior horn cell (lower motor neuron) and corticospinal tract (upper motor neuron) dysfunction ...
C E, Jackson, J, Rosenfeld
openaire   +2 more sources

Motor Neurons

Comprehensive Physiology, 2017
ABSTRACT Motor neurons translate synaptic input from widely distributed premotor networks into patterns of action potentials that orchestrate motor unit force and motor behavior. Intercalated between the CNS and muscles, motor neurons add to and adjust the final motor command.
openaire   +3 more sources

Motor neurone disease

2018
Motor neurone disease (MND) patients exhibit poor gait, balance, and postural control, all of which significantly increases their risk of falling. Falls are frequent in the MND population, and are associated with an increased burden of disease. The complex interplay of both motor and extramotor manifestations in this disease contributes to the ...
Thanuja, Dharmadasa   +4 more
openaire   +2 more sources

“A” motor neuron disease

Journal of the Neurological Sciences, 2014
Allgrove syndrome is a rare autosomal recessive disorder characterised by achalasia, alacrima, adrenal insufficiency, autonomic dysfunction and amyotrophy. The syndrome has been described in childhood and adult presentation, as in our case, is very rare.
Venugopalan Y, Vishnu   +4 more
openaire   +2 more sources

Motor neurone metabolism

Journal of the Neurological Sciences, 1999
The cell and molecular mechanisms which determine the motor neurone (MN) phenotype are unclear. Tissue culture models offer a unique system for the study of a wide variety of MN features. For instance, since the neurone-astrocyte metabolic interactions play a critical role in the selective MN loss observed in amyotrophic lateral sclerosis (ALS), the ...
V. Silani   +4 more
openaire   +2 more sources

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