Results 241 to 250 of about 2,514,411 (397)

Beyond motor neurons: autonomic dysfunction and ECG findings in adults with 5q-spinal muscular atrophy. [PDF]

J Neurol
Bacara K, Stojanovic SD, Wohnrade C, Osmanovic A, Schreiber-Katz O, Haghikia A, Petri S, Bjelica B.   +7 more
europepmc   +1 more source

CX3CL1 in Early Detection of Alzheimer's Disease: Plasma Dynamics Across Age and Disease Stages

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Backgrounds Alzheimer's disease (AD) is characterized by amyloid‐beta plaques, tau tangles, and neuroinflammation. C‐X3‐C motif chemokine ligand 1 (CX3CL1, also known as fractalkine), a neuroimmune chemokine implicated in AD pathogenesis, shows inconsistent alterations in plasma/serum across studies.
Ling Wang, Yujie Liu, Fei Li, Xuelin Li, Lanlan Li, Jie Zhang, Yali Xu   +6 more
wiley   +1 more source

Intrinsically accelerated cellular degradation is amplified by TDP-43 loss in ALS-vulnerable motor neurons in a zebrafish model. [PDF]

Nat Commun
Asakawa K, Tomita T, Shioya S, Handa H, Saeki Y, Kawakami K.   +5 more
europepmc   +1 more source

siRNA screen of ES cell-derived motor neurons identifies novel regulators of tetanus toxin and neurotrophin receptor trafficking [PDF]

, 2014
Marco Terenzio, Matt Golding, Giampietro Schiavo   +2 more
openalex   +1 more source

Astrocytes expressing ALS-linked mutated SOD1 release factors selectively toxic to motor neurons

Nature Neuroscience, 2007
M. Nagai, D. Re, T. Nagata, A. Chalazonitis, T. Jessell, H. Wichterle, S. Przedborski   +6 more
semanticscholar   +1 more source

Fluid Biomarkers of Disease Burden and Cognitive Dysfunction in Progressive Supranuclear Palsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Identifying objective biomarkers for progressive supranuclear palsy (PSP) is crucial to improving diagnosis and establishing clinical trial and treatment endpoints. This study evaluated fluid biomarkers in PSP versus controls and their associations with regional 18F‐PI‐2620 tau‐PET, clinical, and cognitive outcomes.
Roxane Dilcher, Charles B. Malpas, Stuart J. McDonald, William T. O’Brien, Craig Despott, Kelly L. Bertram, Matthew P. Pase, Lukas Frontzkowski, Meng Law, Terence J. O’Brien, Lucy Vivash   +10 more
wiley   +1 more source

Integrated profiling of iPSC-derived motor neurons carrying C9orf72, FUS, TARDBP, or SOD1 mutations. [PDF]

Stem Cell Reports
Ma GM, Xia CC, Lyu BY, Liu J, Luo F, Guan MF, Wang JY, Sun L, Zhang L, Chen Y, Mao YW, Yu GQ, Wang WY.   +12 more
europepmc   +1 more source

Intrinsic membrane hyperexcitability of amyotrophic lateral sclerosis patient-derived motor neurons.

Cell Reports, 2014
Brian J. Wainger, E. Kiskinis, Cassidy Mellin, Ole Wiskow, Steve S. W. Han, Jackson Sandoe, Numa P. Perez, Luis A. Williams, Seungkyu Lee, G. Boulting, J. Berry, Robert H. Brown, M. Cudkowicz, B. Bean, K. Eggan, C. Woolf   +15 more
semanticscholar   +1 more source

Associations of Sleep and Shift Work with Osteoarthritis Risk

Arthritis Care &Research, Accepted Article.
Objective Daily rhythms may be critical for maintaining homeostasis of joint tissues. We aimed to investigate the relationships between circadian clock disruption, sleep, and osteoarthritis (OA) risk in humans. Methods In the UK Biobank, a prospective 500,000‐person cohort, we evaluated associations between sleep duration, sleeplessness/insomnia, and ...
Elizabeth L. Yanik, Abigail Bridgeman, Erik D. Herzog, Vy Pham, Bradley A. Evanoff, Farshid Guilak   +5 more
wiley   +1 more source

Large-scale drug screening in iPSC-derived motor neurons from sporadic ALS patients identifies a potential combinatorial therapy. [PDF]

Nat Neurosci
Bye CR, Qian E, Lim K, Daniszewski M, Garton FC, Trần-Lê BC, Liang HH, Lin T, Lock JG, Crombie DE, Morgan S, Hu Y, Barton SK, Palmer LM, Djouma E, Kodikara S, Lê Cao KA, Dharmadasa T, Henders AK, Ziser LA, Kiernan MC, Talbot K, Needham M, Fletcher S, Talman P, Mathers S, Wray NR, Hewitt AW, Pebay A, Turner BJ.   +29 more
europepmc   +1 more source