Advanced Healthcare Materials, EarlyView.The tissue and functional benefits are demonstrated with local, sustained delivery of an anti‐inflammatory peptide, pituitary adenylate cyclase‐activating polypeptide (PACAP), for stroke treatment in a mouse model. Prolonged PACAP treatment modulated astrocyte and microglia toward pro‐reparative phenotypes, enhanced neuroprotection and preservation of ...
Eric Ho +7 more
wiley +1 more source
Synchronous 3D patterning of diverse CNS progenitors generates motor neurons of broad axial identity
Buchner F +7 more
europepmc +1 more source
Effects of the nerve agent VX on hiPSC-derived motor neurons. [PDF]
Arch ToxicolSchaefers C +6 more
europepmc +1 more source
Magnetic‐Driven Torque‐Induced Electrical Stimulation for Millisecond‐Scale Wireless Neuromodulation
Advanced Healthcare Materials, EarlyView.MagTIES is a wireless neuromodulation technique with millisecond precision. It employs magnetic‐driven torque from magnetite nanodiscs to activate piezoelectric nanoparticles, enabling precise temporal control of neuronal activity and brain oscillations using weak, low‐frequency magnetic fields.
Chao‐Chun Cheng +5 more
wiley +1 more source
Multifunctional Biomedical Devices with Closed‐Loop Systems for Precision Therapy
Advanced Healthcare Materials, EarlyView.This review explores two major types of closed‐loop therapeutic systems: self‐sustained and externally triggered. It highlights recent advances in stimuli‐responsive materials, integrated bioelectronics, and data‐driven control strategies, offering insight into emerging strategies for personalized, responsive drug delivery.
Yixuan Leng, Rujie Sun
wiley +1 more source
Dynactin-1 mediates rescue of impaired axonal transport due to reduced mitochondrial bioenergetics in amyotrophic lateral sclerosis motor neurons. [PDF]
Brain CommunDafinca R +8 more
europepmc +1 more source
Integration of Bioengineered Tools in Assisted Reproductive Technologies
Advanced Healthcare Materials, EarlyView.A conceptual illustration depicting the collaboration between a medical professional (right) and a scientist (left). Their connection highlights the integration of scientific research and clinical practice. This representation underscores the role of emerging technologies in bridging fundamental research with applied reproductive healthcare.
Aslı Ak +3 more
wiley +1 more source
KIF1A, R1457Q, and P1688L Mutations Induce Protein Abnormal Aggregation and Autophagy Impairment in iPSC-Derived Motor Neurons. [PDF]
BiomedicinesZhao M +9 more
europepmc +1 more source
Advanced Healthcare Materials, EarlyView.Extracellular vesicles (EVs) are pivotal mediators of intercellular communication and disease, yet the fundamental mechanisms controlling their biogenesis and cargo selection remain unclear. This limitation hinders their diagnostic utility and therapeutic development.
Luís Carvalho Ferraz +2 more
wiley +1 more source
Spinal inhibitory neurons degenerate before motor neurons and excitatory neurons in a mouse model of ALS. [PDF]
Sci AdvMontañana-Rosell R +7 more
europepmc +1 more source