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Neurons but Motor Neurons in Motor Neuron disease
Italian journal of anatomy and embryology, 2013The occurrence of motor neuron death is the milestone of amyotrophic lateral sclerosis (ALS). Therefore, morphological analysis along decades focussed on motor neuron loss as the sole marker to score disease severity. Recently, non autonomous cell death took a prominent role to explain the need for additional cell types to induce motor neuron ...
Antonio Paparelli +8 more
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Journal of the Neurological Sciences, 1999
The cell and molecular mechanisms which determine the motor neurone (MN) phenotype are unclear. Tissue culture models offer a unique system for the study of a wide variety of MN features. For instance, since the neurone-astrocyte metabolic interactions play a critical role in the selective MN loss observed in amyotrophic lateral sclerosis (ALS), the ...
V. Silani +4 more
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The cell and molecular mechanisms which determine the motor neurone (MN) phenotype are unclear. Tissue culture models offer a unique system for the study of a wide variety of MN features. For instance, since the neurone-astrocyte metabolic interactions play a critical role in the selective MN loss observed in amyotrophic lateral sclerosis (ALS), the ...
V. Silani +4 more
openaire +3 more sources
International Review of Neurobiology, 1999
Publisher Summary This chapter describes three sensory-to-motor reflexes and their associated central circuits and synapses. The uniquely identifiable neurons comprising these reflex circuits offer an excellent opportunity for investigating detailed molecular mechanisms underlying the development and operation of the central nervous system (CNS ...
James R. Trimarchi +2 more
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Publisher Summary This chapter describes three sensory-to-motor reflexes and their associated central circuits and synapses. The uniquely identifiable neurons comprising these reflex circuits offer an excellent opportunity for investigating detailed molecular mechanisms underlying the development and operation of the central nervous system (CNS ...
James R. Trimarchi +2 more
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Physical Medicine and Rehabilitation Clinics of North America, 2001
Motor neuron disease refers to a spectrum of disorders resulting from degeneration of the upper or lower motor neurons or both. Amyotrophic lateral sclerosis is the most common form of motor neuron disease, in which patients demonstrate evidence of both anterior horn cell (lower motor neuron) and corticospinal tract (upper motor neuron) dysfunction ...
Carlayne E. Jackson, Jeffrey Rosenfeld
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Motor neuron disease refers to a spectrum of disorders resulting from degeneration of the upper or lower motor neurons or both. Amyotrophic lateral sclerosis is the most common form of motor neuron disease, in which patients demonstrate evidence of both anterior horn cell (lower motor neuron) and corticospinal tract (upper motor neuron) dysfunction ...
Carlayne E. Jackson, Jeffrey Rosenfeld
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Comprehensive Physiology, 2017
ABSTRACTMotor neurons translate synaptic input from widely distributed premotor networks into patterns of action potentials that orchestrate motor unit force and motor behavior. Intercalated between the CNS and muscles, motor neurons add to and adjust the final motor command.
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ABSTRACTMotor neurons translate synaptic input from widely distributed premotor networks into patterns of action potentials that orchestrate motor unit force and motor behavior. Intercalated between the CNS and muscles, motor neurons add to and adjust the final motor command.
openaire +3 more sources
Journal of the Neurological Sciences, 2014
Allgrove syndrome is a rare autosomal recessive disorder characterised by achalasia, alacrima, adrenal insufficiency, autonomic dysfunction and amyotrophy. The syndrome has been described in childhood and adult presentation, as in our case, is very rare.
Manoj Kumar Goyal +4 more
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Allgrove syndrome is a rare autosomal recessive disorder characterised by achalasia, alacrima, adrenal insufficiency, autonomic dysfunction and amyotrophy. The syndrome has been described in childhood and adult presentation, as in our case, is very rare.
Manoj Kumar Goyal +4 more
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2018
Motor neurone disease (MND) patients exhibit poor gait, balance, and postural control, all of which significantly increases their risk of falling. Falls are frequent in the MND population, and are associated with an increased burden of disease. The complex interplay of both motor and extramotor manifestations in this disease contributes to the ...
William Huynh +4 more
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Motor neurone disease (MND) patients exhibit poor gait, balance, and postural control, all of which significantly increases their risk of falling. Falls are frequent in the MND population, and are associated with an increased burden of disease. The complex interplay of both motor and extramotor manifestations in this disease contributes to the ...
William Huynh +4 more
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Of mice, men and motor neurons
Trends in Molecular Medicine, 2001The use of mouse models has been of particular importance in studying the pathogenesis of amyotrophic lateral sclerosis. Here, we describe both transgenic and classical mutants for which the genetic lesion is known. We draw attention, wherever possible, to pathological factors common to multiple models.
Catherine M. Abbott, Helen J Newbery
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Motor neurons rely on motor proteins
Trends in Cell Biology, 2004The importance of active axonal transport to the neuron has been highlighted by the recent discoveries that mutations in microtubule motor proteins result in neurodegenerative diseases. Mutations affecting microtubule motor function have been shown to cause hereditary forms of Charcot-Marie-Tooth disease (type 2A), hereditary spastic paraplegia and ...
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Nursing Standard, 2016
Essential facts Motor neurone disease describes a group of related diseases, affecting the neurones in the brain and spinal cord. Progressive, incurable and life-limiting, MND is rare, with about 1,100 people developing it each year in the UK and up to 5,000 people affected at any one time.
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Essential facts Motor neurone disease describes a group of related diseases, affecting the neurones in the brain and spinal cord. Progressive, incurable and life-limiting, MND is rare, with about 1,100 people developing it each year in the UK and up to 5,000 people affected at any one time.
openaire +2 more sources