Results 321 to 330 of about 555,245 (354)

Motor neuron disease

2018
Motor neuron disease (MND) is characterized by progressive muscular weakness due to simultaneous degeneration of lower and upper motor neurons (L/UMNs). Involvement of LMNs, arising from the anterior horns of the spinal cord and brainstem, leads to secondary wasting as a result of muscle denervation.
openaire   +1 more source

Autophagy in motor neuron diseases

2020
Motor neuron diseases (MNDs) are a wide group of neurodegenerative disorders characterized by the degeneration of a specific neuronal type located in the central nervous system, the motor neuron (MN). There are two main types of MNs, spinal and cortical MNs and depending on the type of MND, one or both types are affected.
openaire   +3 more sources

Astrocytes in Motor Neuron Diseases

2019
Motor neuron disorders are highly debilitating and mostly fatal conditions for which only limited therapeutic options are available. To overcome this limitation and develop more effective therapeutic strategies, it is critical to discover the pathogenic mechanisms that trigger and sustain motor neuron degeneration with the greatest accuracy and detail.
Valori, Chiara F., Guidotti, Giulia, Brambilla, Liliana, Rossi, Daniela   +3 more
openaire   +3 more sources

Trophic protection of motor neurons: clinical potential in motor neuron diseases

Journal of Neurology, 1994
Recent advances in understanding the physiologic role of nerve growth factor (NGF), obtained both from tissue culture and efficacy studies in animals, have suggested that neurotrophic factors may have clinical potential in the treatment of neurodegenerative diseases or nerve trauma [12,21].
openaire   +3 more sources

Motor neurone disease and the life of motor neurones

Medical Journal of Australia, 1997
Jacqueline A Bansal, Amolak S Bansal
openaire   +2 more sources

Selective motor activation in organelle transport along axons

Nature Reviews Molecular Cell Biology, 2022
Sydney E Cason, Erika L F Holzbaur
exaly  

Activity-dependent spinal cord neuromodulation rapidly restores trunk and leg motor functions after complete paralysis

Nature Medicine, 2022
Andreas Rowald, Robin Demesmaeker, Edeny Baaklini   +2 more
exaly  

Comparative cellular analysis of motor cortex in human, marmoset and mouse

Nature, 2021
Trygve E Bakken, Blue B Lake, Brian E Kalmbach   +2 more
exaly  

Motor neurone disease and the life of motor neurones

Medical Journal of Australia, 1996
openaire   +3 more sources

A multimodal cell census and atlas of the mammalian primary motor cortex

Nature, 2021
Edward M Callaway, Hong-Wei Dong, Joseph R Ecker   +2 more
exaly