Results 321 to 330 of about 536,263 (355)
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2013
Motor neuron diseases (MNDs) represent a group of neurological diseases characterized by progressive deterioration of the motor neurons in the brain, brain stem, and spinal cord, leading to muscle weakness and wasting. Genetic MND may be caused by mutations in genes that are widely expressed.
Quijano-Roy, S. +4 more
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Motor neuron diseases (MNDs) represent a group of neurological diseases characterized by progressive deterioration of the motor neurons in the brain, brain stem, and spinal cord, leading to muscle weakness and wasting. Genetic MND may be caused by mutations in genes that are widely expressed.
Quijano-Roy, S. +4 more
openaire +3 more sources
Autophagy in motor neuron diseases
2020Motor neuron diseases (MNDs) are a wide group of neurodegenerative disorders characterized by the degeneration of a specific neuronal type located in the central nervous system, the motor neuron (MN). There are two main types of MNs, spinal and cortical MNs and depending on the type of MND, one or both types are affected.
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Astrocytes in Motor Neuron Diseases
2019Motor neuron disorders are highly debilitating and mostly fatal conditions for which only limited therapeutic options are available. To overcome this limitation and develop more effective therapeutic strategies, it is critical to discover the pathogenic mechanisms that trigger and sustain motor neuron degeneration with the greatest accuracy and detail.
Valori, Chiara F. +3 more
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2018
Motor neuron disease (MND) is characterized by progressive muscular weakness due to simultaneous degeneration of lower and upper motor neurons (L/UMNs). Involvement of LMNs, arising from the anterior horns of the spinal cord and brainstem, leads to secondary wasting as a result of muscle denervation.
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Motor neuron disease (MND) is characterized by progressive muscular weakness due to simultaneous degeneration of lower and upper motor neurons (L/UMNs). Involvement of LMNs, arising from the anterior horns of the spinal cord and brainstem, leads to secondary wasting as a result of muscle denervation.
openaire +1 more source
Trophic protection of motor neurons: clinical potential in motor neuron diseases
Journal of Neurology, 1994Recent advances in understanding the physiologic role of nerve growth factor (NGF), obtained both from tissue culture and efficacy studies in animals, have suggested that neurotrophic factors may have clinical potential in the treatment of neurodegenerative diseases or nerve trauma [12,21].
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Motor neurone disease and the life of motor neurones
Medical Journal of Australia, 1997Jacqueline A Bansal, Amolak S Bansal
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Motor neurone disease and the life of motor neurones
Medical Journal of Australia, 1996openaire +3 more sources
Reversing a model of Parkinson’s disease with in situ converted nigral neurons
Nature, 2020Don W Cleveland +2 more
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