Results 141 to 150 of about 10,285,166 (306)
FEBS Letters, EarlyView.Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana +3 more
wiley +1 more source
Unlocking the potential of cell‐permeable nanobodies for intracellular applications
FEBS Letters, EarlyView.This review outlines current strategies for delivery of nanobodies into cells and highlights recent examples of functional applications. By addressing and manipulating intracellular targets, these molecules hold great potential for treating cancer, respiratory diseases and neurological disorders, making this a vibrant area of research in the biomedical
Mariona Gené‐Verdés +2 more
wiley +1 more source
تأثير استخدام جدولة التمرين العشوائي والمتسلسل في تعلم بعض مهارات الجمناستک الفني بحث تجريبي على عينة من ذوي الإعاقة البسيطة [PDF]
Maǧallaẗ Asīūṭ Li ʿulūm wa Funūn Al-Tarbiyyaẗ Al-Rīyaḍiyyaẗ, 2015 إقبال عمار لفتة
doaj +1 more source
Behavioral and Brain FunctionsBackground This study investigated the effects of repetitive unihemispheric concurrent dual-site anodal transcranial direct current stimulation (a-tDCSUHCDS) associated with the use of virtual reality games (VR) on the motor coordination of sedentary ...
Nasrin Shahbazi +3 more
doaj +1 more source
Comparing the paths of Hedgehog release in artificial and natural settings
FEBS Letters, EarlyView.Hh morphogens require solubilization factors to overcome their tight association with the plasma membrane and signal to distant cells, but the precise functions of these factors are controversial. Here, we use published in vivo observations as the most relevant evidence to test their suggested functions and discuss contradictions and gaps between in ...
Janna Puschmann, Kay Grobe
wiley +1 more source
How structural disorder and polyelectrolyte properties of prothymosin α enable its large interactome
FEBS Letters, EarlyView.In this review, complexes of the fully disordered and highly negatively charged prothymosin α are collected, described, and discussed. Linked to its poly‐electrostatic character, prothymosin α engages a large interactome through multiple different binding modes ranging from fully disordered complexes to short linear motif (SLiM)‐driven interactions ...
Ketty C. Tamburrini +3 more
wiley +1 more source
Inter-Turn Short Circuit Detection Based on Modulation Signal Bispectrum Analysis of Motor Current Signals [PDF]
, 2013 Motor current signature analysis (MCSA) is a common practice in industry for finding motor faults. However, because of small modulations caused by faults and high noise contamination, it is difficult to quantify the modulation in measured signals which ...
Gu, Fengshou +8 more
core
The Effect of Motor Abilities on Karate Performance
Collegium antropologicum, 2006 The aim of the study was to identify the motor structures that determine achievement of top results in karate. The study included a sample of 85 karateka aged 18-29 years, competing as senior category athletes of the Croatian Karate Society. Fourteen motor tests (9 basic motor tests and 5 specific motor tests) were used to assess technical efficiency ...
Blažević, Stipe +2 more
openaire +3 more sources
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source