Results 191 to 200 of about 143,556 (259)

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Enhancing Visuospatial Working Memory and Motor Skills Through School-Based Coordination Training. [PDF]

Sports (Basel)
Forte P, Pugliese E, Aquino G, Matrisciano C, Carlevaro F, Magno F, Magistro D, D'Anna C.   +7 more
europepmc   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Sex-related differences in fine motor skills and muscle strength control during short-term fasting. [PDF]

Sci Rep
Solianik R, Eimantas N, Daugė G, Brazaitis M.   +3 more
europepmc   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Fundamental Motor Skills Assessments Predicting Academic Performance: A Systematic Review. [PDF]

Med J Islam Repub Iran
Berahimi E, Fatorehchy S, Nobahar Ahari M, Askary Kachoosangy R.   +3 more
europepmc   +1 more source

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source

Schinzel-Giedion syndrome: communication, feeding and motor skills in 16 individuals. [PDF]

Neurogenetics
Morison LD, Summerfield N, Bradley D, van Bon BW, Morgan AT.   +4 more
europepmc   +1 more source

Variables Most Strongly Associated with Motor- and Health-Related Physical Fitness and Motor Skills in Five- to Eight-Year-Old Children: The BC-It and Examin Youth SA Studies. [PDF]

Children (Basel)
Monyeki MA, Pienaar AE, Gericke C, Gerber B.   +3 more
europepmc   +1 more source

Investigating the impact of physical activity on BMI, motor skills, and sleep patterns in elementary school children. [PDF]

Front Public Health
Li X, Ma B.
europepmc   +1 more source