Results 21 to 30 of about 82,429 (269)

Study of the Kinetics of Adhesive Bond Formation Using the Ultrasonic Method

Applied Sciences, 2023
Adhesive bonding is widely used in modern industry. It has many advantages—the main one being the reduction in production costs. It also has certain limitations.
Jakub Kowalczyk, Marian Jósko, Daniel Wieczorek, Kamil Sędłak, Michał Nowak   +4 more
doaj   +1 more source

Acetone and nanoparticles effect on performance and exhaust emissions of a diesel engine

Case Studies in Thermal Engineering, 2023
This research investigated the effects of acetone and metal nano magnesium oxides (MNMgOs) on combustion and emissions in diesel engines. Tests were conducted at various load conditions at a speed of 1500 rpm.
Erdal Çılğın, Halis Deviren, Orhan Arpa   +2 more
doaj   +1 more source

Partially Regular Microreliefs Formed by Rotation

Construction Materials
A new scheme for forming partially regular microreliefs by rotational rolling is proposed. A new transcendental curve-shaped, partially regular microrelief (of a trochoid type) is discussed; the shape and geometric parameters of its grooves are ...
Volodymyr Dzyura, Pavlo Maruschak, Roman Bytsa, Ihor Zinchenko   +3 more
doaj   +1 more source

Imeglimin attenuates liver fibrosis by inhibiting vesicular ATP release from hepatic stellate cells

FEBS Letters, EarlyView.
Imeglimin, at clinically relevant concentrations, inhibits vesicular ATP accumulation and release from hepatic stellate cells, thereby attenuating purinergic signaling and reducing fibrogenic activation. This mechanism reveals a newly identified antifibrotic action of imeglimin beyond glycemic control.
Seiji Nomura, Lixiang Wang, Nao Hasuzawa, Ayako Nagayama, Sawako Moriyama, Kenji Ashida, Yoshinori Moriyama, Masatoshi Nomura, Ken Yamamoto   +8 more
wiley   +1 more source

Determination of Combustion Process Model Parameters in Diesel Engine with Variable Compression Ratio

Journal of Combustion, 2018
Compression ratio has very important influence on fuel economy, emission, and other performances of internal combustion engines. Application of variable compression ratio in diesel engines has a number of benefits, such as limiting maximal in cylinder ...
Saša Milojević, Radivoje Pešić
doaj   +1 more source

Targeting EZH2 reverses thyroid cell dedifferentiation and enhances iodide uptake in anaplastic thyroid cancer

FEBS Letters, EarlyView.
Anaplastic thyroid cancer (ATC) lacks iodide uptake ability due to MAPK activation increasing the expression of the histone methyltransferase EZH2, which represses thyroid differentiation genes (TDGs) such as the sodium iodide symporter (NIS). Dual inhibition of MAPK (U0126) and EZH2 (EPZ6438/Tazemetostat) reverses this mechanism, thus restoring TDG ...
Diego Claro de Mello, Marcella Maringolo Cristovão, Guilherme Henrique, Vinicius Gonçalves Rodrigues, Caroline Serrano‐Nascimento, Edna Teruko Kimura, Cesar Seigi Fuziwara   +6 more
wiley   +1 more source

The zinc finger domains of PARP‐1 are selectively and potently inhibited by the Au(I)‐based drugs sodium aurothiomalate and aurothioglucose

FEBS Letters, EarlyView.
PARP‐1 is a key enzyme in the DNA damage response, and its inhibition induces cancer cell death via synthetic lethality. Au(I)‐based drugs, such as aurothioglucose and sodium aurothiomalate, block PARP‐1's DNA‐dependent activity by targeting its zinc finger domains.
Uliana Bashtanova, Melinda Jane Duer
wiley   +1 more source

Modification of the Surface Layer of Grey Cast Iron by Laser Heat Treatment

Lubricants
This paper presents possible modifications to the properties of grey cast iron by laser heat treatment. These modifications are analyzed especially with regard to wear properties as a result of graphite content, which is a well-known solid lubricant ...
Marta Paczkowska
doaj   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Efficiency assessment of different highspeed tracked vehicle hybrid powertrain conceptions

Vojnotehnički Glasnik
Introduction/purpose: Increased development of hybrid powertrains during the last decade brought high-speed tracked vehicles into the same spotlight as commercial and passenger hybrid vehicles.
Luka M. Ponorac, Ivan A. Blagojević
doaj   +1 more source