Results 61 to 70 of about 528,116 (352)

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Penegakan Hukum Pelanggaran Modifikasi Tanda Nomor Kendaraan Bermotor Berdasarkan Undang-undang Nomor 22 Tahun 2009 Tentang Lalu Lintas dan Angkutan Jalan oleh Kepolisian Satuan Lalu Lintas Resor Kota Pekanbaru [PDF]

, 2016
Traffic violation is a disregard for the rules of traffic carried by the vehicles that cause traffic accidents for other road users, both loss of life and injuries.
Erdiansyah, E. (Erdiansyah), Erdianto, E. (Erdianto), FELASTRI, I. (IKA)   +2 more
core  

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Defectoscopic Susceptibility of Machine Elements

Communications, 2005
In the paper defectoscopic susceptibility of machine elements is analyzed. At first, an objective notion is defined and presented in a practical situation.
Marian Josko
doaj   +1 more source

Research on Startup Process for Sensorless Control of PMSMs Based on I-F Method Combined With an Adaptive Compensator

IEEE Access, 2020
Speed control of permanent magnet synchronous motors (PMSMs) without position sensors is preferable in some applications due to cost and mounting space concerns.
Jilei Xing, Zhidong Qin, Cheng Lin, Xiongwei Jiang   +3 more
doaj   +1 more source

Dealer connection special edition [PDF]

, 2022
This newsletter published by the South Carolina Department of Motor Vehicles provides information about difference ways in which dealers and business customers can process their transactions, from electronic vehicle registrations to in-person ...
South Carolina Department of Motor Vehicles
core  

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Efficiency Assessment of a High-Speed Tracked Vehicle Hybrid Powertrain

Measurement Science Review
The paper analyzes the difference in power balance and efficiency between a modernized, hybrid high-speed tracked vehicle powertrain model and a mechanical powertrain model corresponding to the real vehicle developed and verified in previous research ...
Ponorac Luka, Blagojević Ivan
doaj   +1 more source

North Carolina License Plate [PDF]

, 1932
North Carolina auto license plate from 1932; number 1.https://digitalcommons.gardner-webb.edu/cleveland-county-historical-collection-ralph-webb-gardner/1002/thumbnail ...
N.C. Division of Motor Vehicles,
core   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source