Results 31 to 40 of about 10,983 (262)

Microglial dynamics and ferroptosis induction in human iPSC‐derived neuron–astrocyte–microglia tri‐cultures

FEBS Open Bio, EarlyView.
A tri‐culture of iPSC‐derived neurons, astrocytes, and microglia treated with ferroptosis inducers as an Induced ferroptosis model was characterized by scRNA‐seq, cell survival, and cytokine release assays. This analysis revealed diverse microglial transcriptomic changes, indicating that the system captures key aspects of the complex cellular ...
Hongmei Lisa Li, Hiroko Ohmiya, Sou Sakamoto, Masato Yugami, Akiko Oki, Makoto Furusawa, Yan Ling   +6 more
wiley   +1 more source

YlmG1 is localized exclusively to the chloroplast envelope membrane and is involved in preprotein translocation in Arabidopsis thaliana

FEBS Open Bio, EarlyView.
Cytosolically synthesized chloroplast preproteins are translocated across the outer and inner envelope membranes through translocons called TOC and TIC, respectively. In green algae and plants, the TIC core is composed of essential membrane proteins, Tic12, Tic20, and Tic214.
Mengyi Li, Xueyang Zhao, Masato Nakai
wiley   +1 more source

Flux weakening control of electric starter-generator based on permanent-magnet machine [PDF]

, 2017
The paper presents control analysis and design for a Permanent Magnet Machine (PMM) operated in Flux-Weakening (FW) mode for an aircraft electric starter-generator application.
Bozhko, Serhiy, Hill, Chris, Rashed, Mohamed, Yang, Tao, Yeoh, Seang Shen   +4 more
core   +1 more source

Motor cortex mapping using active gaussian processes

Proceedings of the 13th ACM International Conference on PErvasive Technologies Related to Assistive Environments, 2020
One important application of transcranial magnetic stimulation (TMS) is to map cortical motor topography by spatially sampling the motor cortex, and recording motor evoked potentials (MEP) with surface electromyography. Standard approaches to TMS mapping involve repetitive stimulations at different loci spaced on a (typically 1 cm) grid on the scalp ...
Razieh, Faghihpirayesh, Tales, Imbiriba, Mathew, Yarossi, Eugene, Tunik, Dana, Brooks, Deniz, Erdoğmuş   +5 more
openaire   +3 more sources

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Computationally Efficient Strand Eddy Current Loss Calculation in Electric Machines [PDF]

, 2019
A fast finite element (FE) based method for the calculation of eddy current losses in the stator windings of randomly wound electric machines is presented in this paper.
Chong, Yew Chuan, Demerdash, Nabeel, Fatemi, Alireza, Ionel, Dan M., Staton, Dave A., Wrobel, Rafal   +5 more
core   +1 more source

A Computationally Efficient Method for Calculation of Strand Eddy Current Losses in Electric Machines [PDF]

, 2016
In this paper, a fast finite element (FE)-based method for the calculation of eddy current losses in the stator windings of randomly wound electric machines with a focus on fractional slot concentrated winding (FSCW) permanent magnet (PM) machines will ...
Chuan Chong, Yew, Demerdash, Nabeel, Fatemi, Alireza, Ionel, Dan M., Staton, Dave A., Wrobel, Rafal   +5 more
core   +2 more sources

Chronotopic maps in human supplementary motor area [PDF]

PLOS Biology, 2019
Time is a fundamental dimension of everyday experiences. We can unmistakably sense its passage and adjust our behavior accordingly. Despite its ubiquity, the neuronal mechanisms underlying the capacity to perceive time remains unclear. Here, in two experiments using ultrahigh-field 7-Tesla (7T) functional magnetic resonance imaging (fMRI), we show that
Foteini Protopapa, Masamichi J. Hayashi, Shrikanth Kulashekhar, Wietske van der Zwaag, Giovanni Battistella, Micah M. Murray, Ryota Kanai, Domenica Bueti   +7 more
openaire   +4 more sources

Intercompartmental communication in senescence

FEBS Open Bio, EarlyView.
Senescent cells experience structural changes in the plasma membrane, endoplasmic reticulum, mitochondria, lysosomes, nucleus, and cytoskeleton. These alterations disrupt crosstalk among cellular compartments, impairing vesicular trafficking, contact sites, and molecular flow.
Krystyna Mazan‐Mamczarz, Eleanor J. Wind, Jixiang Leng, Myriam Gorospe   +3 more
wiley   +1 more source