Results 31 to 40 of about 407 (254)
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Are we there yet? The temporal dynamics of motoring branded content
, 2023 The unprecedented petrol price hike in July 2022 did not see motorists falling out of love with the car. From the earliest days of motoring, it has always been more than engineering, performance and speed.
Powell, H.
core
FEBS Letters, EarlyView.Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley +1 more source
FEBS Letters, EarlyView.Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara +3 more
wiley +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Route guidance system based on self-adaptive algorithm [PDF]
, 2012 Self-adaptive systems are applied in a variety of ways, including transportation, telecommunications, etc. The main challenge in route guidance system is to direct vehicles to their destination in a dynamic traffic situation, with the aim of reducing the
Mortaza Zolfpour-Arokhlo +7 more
core +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
FEBS Open Bio, EarlyView.Cytosolically synthesized chloroplast preproteins are translocated across the outer and inner envelope membranes through translocons called TOC and TIC, respectively. In green algae and plants, the TIC core is composed of essential membrane proteins, Tic12, Tic20, and Tic214.
Mengyi Li, Xueyang Zhao, Masato Nakai
wiley +1 more source
The Chorography of the Modern City [PDF]
, 2017 Until the nineteenth century, space was represented and produced through mathematically constructed drawings: plans and sections captured buildings and the scientific map recorded the territory. The development of technologies of transport brought crisis
Garcia De Cortazar Galleguillos, Gabriela
core +1 more source
URBANISATION AND UNEVEN DEVELOPMENT OF TOURISM ON THE BRAZILIAN COAST
, 2022 The concentration of tourism on the Brazilian coast is widely recognised, despite the fact that its development does not take place in an even manner along the entirety of the coast.
Sergio Moraes Rego Fagerlande (13962937) +3 more
core +1 more source