Results 171 to 180 of about 3,039,643 (308)

The Maintenance of Dysmyelinated Small-Diameter Axons by 14-3-3s in the Central Nervous System. [PDF]

Glia
Yamada N, Saito H, Takahashi R, Fujisato M, Hosoda Y, Sasaki B, Yamada M, Abe S, Hayashi C, Yoshimoto A, Ohkawa R, Matt TJ, M Bareyre F, Berghoff S, Simons M, Suzuki N.   +15 more
europepmc   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Cutaneous Mast Cell Tumor With Metastasis in a Pet Cairo Spiny Mouse (<i>Acomys cahirinus</i>): A Case Report With Clinicopathologic Characterization. [PDF]

Case Rep Vet Med
Anderson SE, Smith A, Nelson SR, Kuroki K.   +3 more
europepmc   +1 more source

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

Determination of Hecogenin in Mouse Blood by UPLC-MS/MS and Applied to a Pharmacokinetic Study. [PDF]

Biomed Chromatogr
Hu Y, Zhu L, Xiang X, Zou T, Wen C, Duan Q.   +5 more
europepmc   +1 more source

NAPRT loss promotes lung tumor initiation and growth through AKT signaling independently of NAD+ biosynthesis

Molecular Oncology, EarlyView.
Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh, Ji Yun Jang, Yoon Jeon, Gi‐Cheon Kim, Hwanho Lee, Jooyoung Lee, Ju‐Hwa Kim, Hakhyun Kim, Minjee Kim, Ho‐Keun Kwon, Ho Lee, Hyun Seok Kim   +11 more
wiley   +1 more source

A Comparison of Neutrophil Secretion of Cytokines and NET Formation in Response to Lipopolysaccharide and Group B <i>Streptococcus</i> (GBS) in Mice and Rats in vitro. [PDF]

J Inflamm Res
Bauch S, Stoll J, Lieubeau B, Meurer M, von Köckritz-Blickwede M, Leisengang S, Conejeros I, Harden LM, Hernandez J, Hervé J, Rummel C.   +10 more
europepmc   +1 more source

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

Unlocking <i>cis</i>-regulatory landscapes across 500 million years of evolution and disease mechanisms. [PDF]

NAR Genom Bioinform
Mangetti Gonçalves T, Stewart CL, Baxley SD, Xu J, Boyer K, George B, Li D, Yang C, Gabel HW, Piao X, Cruchaga C, Li YE, Wang T, Avraham O, Zhao G.   +14 more
europepmc   +1 more source