Results 191 to 200 of about 1,832,552 (317)

Immunodynamic changes in a mouse model of malignant pleural effusion. [PDF]

Lab Anim Res
Wei XL, Guo X, Zhang CX, Wang Q, Liu XF, Shao MM, Shi HZ, Zhai K.   +7 more
europepmc   +1 more source

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source

The impact of cytomegalovirus coinfection on tuberculosis in the mouse model. [PDF]

BMC Infect Dis
Marschner J, Marwitz S, Eggers L, von Borstel L, Buer L, Hertz D, Goldmann T, Ostermann E, Brune W, Schneider BE.   +9 more
europepmc   +1 more source

MiR‐513a promotes human erythroid differentiation by modulating c‐Jun

FEBS Open Bio, EarlyView.
During early human erythropoiesis, miR‐513a promoted erythroid differentiation in primary human CD34+ hematopoietic stem‐progenitor cells and human TF‐1 erythroleukemic cells by indirectly decreasing c‐Jun and phospho‐c‐Jun expression, which are associated with increased GATA1 expression.
MinJung Kim, Brittany Taylor, Shannon Bolten, Christian L. Eberly, Mahliya Abdurahman, T. Michael Creed, Acong Yang, Taylor L. Hatchet, Tristan Dyson, Shuo Gu, Curt I. Civin, Tami J. Kingsbury   +11 more
wiley   +1 more source

Corneal Immune Cell Alterations and Tau Pathology in a Mouse Model of Alzheimer's Disease. [PDF]

Invest Ophthalmol Vis Sci
Zhang D, Huang D, He J, Shen Y, Dai L, Shi L.   +5 more
europepmc   +1 more source

Combined 5‐aminolevulinic acid and ferric ammonium citrate treatment promotes hair follicle growth by activating dermal papilla cells

FEBS Open Bio, EarlyView.
5‐Aminolevulinic acid combined with ferric ammonium citrate (5‐ALA/FAC) stimulates dermal papilla cell activity and promotes hair follicle growth. The treatment enhances ERK and AKT signaling, increases hair‐inductive gene expression, and restores dermal papilla function suppressed by dihydrotestosterone and oxidative stress, resulting in enhanced hair
Han‐Wook Ryu, Eok‐Soo Oh, Sewoon Kim
wiley   +1 more source

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

ELP1 gene augmentation restores visual function in a mouse model of familial dysautonomia. [PDF]

Mol Ther
Cheng HC, Koli S, Lewis K, Ketchale S, Anvarinia Y, Erdoes M, Liu Y, Keiper CE, Estelien R, Chagnon M, Vandenberghe LH, Gao D, Lefcort F, Morini E, Slaugenhaupt SA, Chekuri A.   +15 more
europepmc   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Introducing PIGMO, a novel PIGmented MOuse model of Parkinson's disease. [PDF]

NPJ Parkinsons Dis
Chocarro J, Marana S, Espelosin M, Rico AJ, Ariznabarreta G, Lorenzo-Ramos E, Ilarduya MM, Hernandez-Alcoceba R, Chillón M, Vila M, Kordower JH, Schapira AHV, Garcia-Osta A, Cuadrado-Tejedor MDM, Lanciego JL.   +14 more
europepmc   +1 more source