Results 91 to 100 of about 85,433 (307)

Smart, Bio‐Inspired Polymers and Bio‐Based Molecules Modified by Zwitterionic Motifs to Design Next‐Generation Materials for Medical Applications

Advanced Functional Materials, EarlyView.
Bio‐based and (semi‐)synthetic zwitterion‐modified novel materials and fully synthetic next‐generation alternatives show the importance of material design for different biomedical applications. The zwitterionic character affects the physiochemical behavior of the material and deepens the understanding of chemical interaction mechanisms within the ...
Theresa M. Lutz, Jonas De Breuck, Sahar Salehi, Meike N. Leiske   +3 more
wiley   +1 more source

Fatores clínicos e histológicos preditivos de metástase cervical em carcinomas epidermóides de língua e soalho de boca no estadio clínico II

Revista do Colégio Brasileiro de Cirurgiões
O encontro de fatores preditivos de metástase cervical seria de grande valia para o tratamento de pacientes com tumores de alto potencial metastatizante e com pescoço clinicamente negativo.
João Marcos Arantes Soares, Abrão Rapoport, Marilene Paladino Rosas, Marcos Brasilino de Carvalho, Antônio Sérgio Fava   +4 more
doaj   +1 more source

Transient rapamycin treatment can increase lifespan and healthspan in middle-aged mice [PDF]

, 2016
The FDA approved drug rapamycin increases lifespan in rodents and delays age-related dysfunction in rodents and humans. Nevertheless, important questions remain regarding the optimal dose, duration, and mechanisms of action in the context of healthy ...
Anderson, Anisimov, Atarashi, Augustine, Bates, Blackwell, Chen, Dai, de Oliveira, Ericsson, Ericsson, Flynn, Goldman, Halloran, Hard, Harrison, Hothorn, Johnson, Johnson, Johnson, Kaeberlein, Lamming, Majumder, Mannick, Mathew, Miller, Miller, Paulson, Prakash, Ramos, Treuting, Wilkinson, Xu, Zhang   +33 more
core   +1 more source

Pulmonary Delivery of siRNA Anti‐TNFα‐loaded Lipid Nanoparticles for Rapid Recovery in Murine Acute Lung Injury

Advanced Healthcare Materials, EarlyView.
In a murine model of acute lung injury, pulmonary administration of lipid nanoparticles carrying TNFα siRNA enables targeted delivery to immune cells. The study emphasises the importance of optimizing LNP distribution and delivery timing to improve therapeutic outcomes and develop emergency therapies for lung hyperinflammation.
Qinglin Wang, Jihana Achour, Laila Emam, Younes Louaguenouni, Catherine Cailleau, Françoise Mercier‐Nomé, Séverine Domenichini, Claudine Delomenie, Sezen Gul, Juliette Vergnaud, Nicolas Tsapis, Arnaud Mansart, Djillali Annane, Francois Fay, Elias Fattal   +14 more
wiley   +1 more source

Cortisol Secreting Adrenal Adenoma in a 5 Year Old Child [PDF]

, 2011
Adrenal adenoma is a rare endocrinal tumor in children. It can present with features of Cushing's syndrome. We present a case report of five years old female child who came with morbid obesity and hypertension.
Narang, Gursharan Singh, Pahwa, Jivtesh Singh   +1 more
core  

Conditioned Media from Mechanically Stimulated Macrophages Upregulate Osteogenic Genes in Human Mesenchymal Stromal Cells

Advanced Healthcare Materials, EarlyView.
Bone fracture healing is a complex, timely orchestrated scenario involving multiple cell types and a plethora of cytokines and regulatory factors. To gain further insight, an in vitro model to a) study macrophage polarization under mechanical load in a fibrin hydrogel and b) subsequently assess the effect of conditioned media derived from macrophages ...
Anne Géraldine Guex, Ursula Menzel, Yann Ladner, Angela R. Armiento, Martin J. Stoddart   +4 more
wiley   +1 more source

Multifunctional Biomedical Devices with Closed‐Loop Systems for Precision Therapy

Advanced Healthcare Materials, EarlyView.
This review explores two major types of closed‐loop therapeutic systems: self‐sustained and externally triggered. It highlights recent advances in stimuli‐responsive materials, integrated bioelectronics, and data‐driven control strategies, offering insight into emerging strategies for personalized, responsive drug delivery.
Yixuan Leng, Rujie Sun
wiley   +1 more source

A Novel Brain Penetrable Nanocarrier Delivers Brain‐Derived Neurotrophic Factor to Treat Alzheimer's Disease

Advanced Healthcare Materials, EarlyView.
A novel blood‐brain barrier‐penetrating terpolymer nanoparticle to deliver brain‐derived neurotrophic factor (BDNF) for the treatment of Alzheimer's disease (AD) is designed. The BDNF‐TPN significantly enhances BDNF accumulation in the brain following intravenous injection, reduces apoptosis and neuroinflammation, thus promoting neuronal survival and ...
Lily Yi Li, Elliya Park, Chunsheng He, Azhar Z. Abbasi, Pei Zhi, Paul E. Fraser, Andrew M. Rauth, Jeffery T. Henderson, Xiao Yu Wu   +8 more
wiley   +1 more source

Photoactivated Proximity Protein Labeling Reveals Enhanced Tumor Retention of a D‐Peptide‐Ruthenium Prodrug Conjugate

Advanced Healthcare Materials, EarlyView.
Six stereoisomeric ruthenium‐peptide conjugates were synthesized and characterized, which showed high potential in photoactivated chemotherapy (PACT) and proximity protein labeling. Abstract Amino acid chirality is known to influence the biological properties of peptide‐containing prodrugs.
Liyan Zhang, Peiyuan Wang, Hildert Bronkhorst, Yurii Husiev, Ludovic Bretin, Maarten N. van Ginkel, Wen Sun, Sylvestre Bonnet   +7 more
wiley   +1 more source

Why is Mouth Self-Examination Still Not Recommended for Early Detection of Oral Cancer and Oral Potentially Malignant Disorders?

Revista Brasileira de Cancerologia
Oral self-examination still remains enigmatic considering its functionality in detecting malignant disorders in the mouth. Although this tool is not concretely implemented in any health service, several studies have considered it as a real possibility ...
Beatriz Monteiro da Silva, José Alexandre da Rocha Curvelo, Ruteléia dos Santos Assumpção Barroso, João Vitor Silveira de Azevedo, Andreia Cristina de Melo, Daniel Cohen-Goldemberg   +5 more
doaj   +1 more source