Results 51 to 60 of about 668,889 (305)

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Micronucleus level in exfoliated buccal mucosa cells of cancer patients [PDF]

Archive of Oncology, 2002
Micronucleus levels in exfoliated buccal mucosa cells of patients with primary breast, lung, cervix uteri cancer, and patients with Hodgkin's disease were studied (n=59).
Nersesyan Armen K., Vardazaryan Nina S., Gevorgyan Ani L., Arutyunyan Rouben M.   +3 more
doaj   +1 more source

Naked cuticle is essential for Drosophila wing development beyond Wingless signaling

FEBS Open Bio, EarlyView.
Naked cuticle (Nkd), a Wnt signaling inhibitor, assumes extensive roles in Drosophila wing development. Overexpressing Nkd causes smaller, crumpled wings, while also perturbing multiple signaling pathways and developmental genes. A specific region (R1S) is critical for Nkd's function as a signaling integrator, offering new insights for studying its ...
Rui Wang, Ping Wang
wiley   +1 more source

Staging of oral cavity cancer in the 8th edition of the TNM classification: The role of computed tomography in the assessment of depth of invasion and extranodal extension

Brazilian Journal of Otorhinolaryngology
Objective: Suggest and validate pre-surgical tomographic evaluation criteria for OCC based on the pathological DOI criteria. Methods: A retrospective cohort study was conducted with 80 patients with tongue and floor of mouth tumors, T1 and T2, followed ...
Leticia de Franceschi, João Manoel Miranda Magalhães Santo, Anniely Mourão de Abreu, Marco Aurélio Vamondes Kulcsar, Claudio Roberto Cernea, Marcio Ricardo Taveira Garcia, Rogerio Aparecido Dedivitis, Leandro Luongo Matos   +7 more
doaj   +1 more source

Mucoepidermoid carcinoma mimicking a mucocele: a case report highlighting the importance of microscopic analysis of oral lesions

Revista Brasileira de Odontologia, 2018
Objective: the aim of this paper is to report a case of palatal Mucoepidermoid carcinoma (MEC) mimicking a mucocele, to highlight the main differential diagnoses, and to point out the need of a biopsy to establish the diagnosis even in a suspicion of ...
Tamires Thadeu Coelho, Adriele Ferreira Gouvea, Ademar Takahama Jr., Danielle Resende Camisasca, Silvia Paula de Oliveira, Rebeca Souza Azevedo   +5 more
doaj   +1 more source

[Intra-arterial injection of bleomycin in mouth neoplasm].

Nihon Jibiinkoka Gakkai kaiho, 1970
Shigeru Ikejiri
openaire   +2 more sources

Pathogenic Neurofibromatosis type 1 gene variants in tumors of non‐NF1 patients and role of R1276

FEBS Open Bio, EarlyView.
Somatic variants of the neurofibromatosis type 1 (NF1) gene occur across neoplasms without clinical manifestation of the disease NF1. We identified emerging somatic pathogenic NF1 variants and hotspots, for example, at the arginine finger 1276. Those missense variants provide fundamental information about neurofibromin's role in cancer.
Mareike Selig, Swanhild Lohse, Sara Elahi, Nils Hartmann, Stefanie Deckert, Shutian Si, Alexander Desuki, Anja Harder   +7 more
wiley   +1 more source

Enhancing cancer care through addressing a neglected pillar: a narrative review on quality of life in Pakistani patients

Journal of the Pakistan Medical Association
The current narrative review was planned to evaluate the quality of life of Pakistani cancer patients. Using relevant questionnaires and comparing global data over the last 2 decades, the review planned to explore artificial intelligence’s role in ...
Taimoor Khalid Janjua, Saniya Amir, Saad Ullah Khan, Fizza Zulfiqar, Hira Khan Afridi   +4 more
doaj   +1 more source

The role of lipid metabolism in neuronal senescence

FEBS Open Bio, EarlyView.
Disrupted lipid metabolism, through alterations in lipid species or lipid droplet accumulation, can drive neuronal senescence. However, lipid dyshomeostasis can also occur alongside neuronal senescence, further amplifying tissue damage. Delineating how lipid‐induced senescence emerges in neurons and glial cells, and how it contributes to ageing and ...
Dikaia Tsagkari, Eleftheria Panagiotidou, Nektarios Tavernarakis   +2 more
wiley   +1 more source

Prediction Model for Etiologic Differentiation of Isolated Vestibular Syndrome in Emergency Settings

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective This study aimed to develop and validate a predictive model for differentiating central from peripheral etiologies in patients with isolated vestibular syndrome (VS). Methods In this multicenter retrospective cohort study, 506 patients with isolated VS from five hospitals were divided into derivation (n = 301) and validation (n = 205)
Guo Wenting, Du Liping, Yang Yi, Hu Jin, Ye Bijun, Wang Jianer, Liu Shuangsi, Guo Shunyuan, Cai Xiaofeng, Wang Huiyuan, Wu Bin, Yu Xiang, Shi Tianming   +12 more
wiley   +1 more source