Results 61 to 70 of about 12,888 (261)
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Radiological Society of North America (RSNA) 3D printing Special Interest Group (SIG): Guidelines for medical 3D printing and appropriateness for clinical scenarios [PDF]
, 2018 Este número da revista Cadernos de Estudos Sociais estava em organização quando fomos colhidos pela morte do sociólogo Ernesto Laclau. Seu falecimento em 13 de abril de 2014 surpreendeu a todos, e particularmente ao editor Joanildo Burity, que foi seu ...
Ballard, David H, et al,
core +2 more sources
Periodontitis Periodontitis and oral cancer - current concepts of the etiopathogenesis
Oncology Reviews, 2020 Gingival tissues are attacked by oral pathogens which can induce inflammatory reactions. The immune-inflammatory responses play essential roles in the patient susceptibility to periodontal diseases. There is a wealth of evidence indicating a link between
Soussan Irani +2 more
doaj +1 more source
Brazilian Oral Research, 2023 This study aimed to evaluate the contribution of oral and maxillofacial pathology laboratories (OMPLs) in Brazilian public universities to the diagnosis of lip, oral cavity, and oropharyngeal squamous cell carcinoma (SCC).
Brendo Vinicius Rodrigues LOUREDO +47 more
doaj +1 more source
Malignant lymphomas in transplantation patients: a review of the world experience. [PDF]
, 1970 Malignant lymphomas developed in 9 renal homograft recipients treated at widely separated transplantation centers. The development of these tumors appears to be an indirect complication of organ transplantation and/or the measures taken to prevent ...
Penn, I, Starzl, TE
core
Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma
Molecular Oncology, EarlyView.Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski +10 more
wiley +1 more source
Brazilian Journal of OtorhinolaryngologyObjective: Suggest and validate pre-surgical tomographic evaluation criteria for OCC based on the pathological DOI criteria. Methods: A retrospective cohort study was conducted with 80 patients with tongue and floor of mouth tumors, T1 and T2, followed ...
Leticia de Franceschi +7 more
doaj +1 more source
Micronucleus level in exfoliated buccal mucosa cells of cancer patients [PDF]
Archive of Oncology, 2002 Micronucleus levels in exfoliated buccal mucosa cells of patients with primary breast, lung, cervix uteri cancer, and patients with Hodgkin's disease were studied (n=59).
Nersesyan Armen K. +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
The paradox of cancer genes in non-malignant conditions: implications for precision medicine. [PDF]
, 2020 Next-generation sequencing has enabled patient selection for targeted drugs, some of which have shown remarkable efficacy in cancers that have the cognate molecular signatures.
Adashek, Jacob J +3 more
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