Results 51 to 60 of about 389,556 (308)

Topographic determinants of foot and mouth disease transmission in the UK 2001 epidemic [PDF]

, 2006
Background A key challenge for modelling infectious disease dynamics is to understand the spatial spread of infection in real landscapes. This ideally requires a parallel record of spatial epidemic spread and a detailed map of susceptible host density ...
Savill Nicholas J, MatthewJ Keeling, Rob Deardon, Grenfell Bryan T, Shaw, Darren J; id_orcid, Savill, Nicholas J., Shaw Darren J, Deardon, Rob, Deardon Rob, Brooks, Stephan P., NicholasJ Savill, Woolhouse Mark EJ, Woolhouse, Mark E. J., Brooks, Stephen P, Grenfell, Bryan T., Keeling Matthew J, MichaelJ Tildesley, Woolhouse, Mark E J; id_orcid, BryanT Grenfell, Tildesley Michael J, Brooks Stephen P, Keeling, Matthew James, Tildesley, Michael J., Keeling, Matthew J, Tildesley, Michael J, Grenfell, Bryan T, MarkEJ Woolhouse, StephenP Brooks, Shaw, Darren J., Savill, Nicholas J, DarrenJ Shaw   +30 more
core   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Ki-67 protein predicts survival in oral squamous carcinoma cells: an immunohistochemical study

Brazilian Oral Research, 2017
The aim of this study was to identify the expression of Ki-67 and MCM3 in oral squamous cell carcinoma (OSCC) as well as to address the correlation with patient survival and clinical features.
Verena Karla Monteiro LOPES, Adriana Souza de JESUS, Lucas Lacerda de SOUZA, Ligia Akiko Ninokata MIYAHARA, Douglas Magno GUIMARÃES, Helder Antônio Rebelo PONTES, Flavia Sirotheau Correa PONTES, Pedro Luiz de CARVALHO   +7 more
doaj   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Staging of oral cavity cancer in the 8th edition of the TNM classification: The role of computed tomography in the assessment of depth of invasion and extranodal extension

Brazilian Journal of Otorhinolaryngology
Objective: Suggest and validate pre-surgical tomographic evaluation criteria for OCC based on the pathological DOI criteria. Methods: A retrospective cohort study was conducted with 80 patients with tongue and floor of mouth tumors, T1 and T2, followed ...
Leticia de Franceschi, João Manoel Miranda Magalhães Santo, Anniely Mourão de Abreu, Marco Aurélio Vamondes Kulcsar, Claudio Roberto Cernea, Marcio Ricardo Taveira Garcia, Rogerio Aparecido Dedivitis, Leandro Luongo Matos   +7 more
doaj   +1 more source

Accuracy of models for the 2001 foot-and-mouth epidemic [PDF]

, 2008
Since 2001 models of the spread of foot-and-mouth disease, supported by the data from the UK epidemic, have been expounded as some of the best examples of problem-driven epidemic models.
Bessell, Paul R., Brooks, Stephen P., R. Deardon, P. R Bessell, M. J Tildesley, Savill, Nicholas J., N. J Savill, S. P Brooks, Keeling, Matthew James, M. E.J Woolhouse, Deardon, Rob, B. T Grenfell, Tildesley, Michael J., Keeling, Matt J., Woolhouse, Mark E. J., Grenfell, Bryan T., M. J Keeling, Woolhouse, Mark E. J.; id_orcid   +17 more
core   +1 more source

NAPRT loss promotes lung tumor initiation and growth through AKT signaling independently of NAD+ biosynthesis

Molecular Oncology, EarlyView.
Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh, Ji Yun Jang, Yoon Jeon, Gi‐Cheon Kim, Hwanho Lee, Jooyoung Lee, Ju‐Hwa Kim, Hakhyun Kim, Minjee Kim, Ho‐Keun Kwon, Ho Lee, Hyun Seok Kim   +11 more
wiley   +1 more source

Micronucleus level in exfoliated buccal mucosa cells of cancer patients [PDF]

Archive of Oncology, 2002
Micronucleus levels in exfoliated buccal mucosa cells of patients with primary breast, lung, cervix uteri cancer, and patients with Hodgkin's disease were studied (n=59).
Nersesyan Armen K., Vardazaryan Nina S., Gevorgyan Ani L., Arutyunyan Rouben M.   +3 more
doaj   +1 more source

Scenarios for eradicating foot-and-mouth disease [PDF]

, 2001
Research project commissioned by the Ministery of Agriculture, Nature Management and Fisheries. With the help of desk-research and input-output analysis quantitative information is assembled about the differences in cost for agribusiness and tourism of ...
Vlieger, J.J., de, Leeuwen, M.G.A., van, Bos, E.J.   +2 more
core  

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source