Results 81 to 90 of about 2,630,512 (318)

PARK(ing) time–How park deficiency affects the biological clock in a Drosophila model of Parkinson's disease

open access: yesFEBS Letters, EarlyView.
Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara   +3 more
wiley   +1 more source

Informing adaptive management to reduce ungulate aggregations: A case study involving winter feeding of elk

open access: yesWildlife Society Bulletin
In the United States, wildlife managers are entrusted with preserving culturally and economically important ungulate populations in the face of the ongoing spread of chronic wasting disease (CWD). The U.S.
William M. Janousek   +3 more
doaj   +1 more source

Impact of physical activity on all-cause mortality in individuals with non-cystic fibrosis bronchiectasis

open access: yesFrontiers in Medicine
BackgroundLittle information is available regarding whether active physical activity lowers mortality risk in individuals with bronchiectasis.MethodsWe used the Korean National Health Insurance Service database from 2010 to 2016 to evaluate the ...
Sang Hyuk Kim   +6 more
doaj   +1 more source

Probing for Intentions: Why Clocks Do Not Provide the Only Measurement of Time

open access: yesFrontiers in Human Neuroscience, 2019
Having an intention to act is commonly operationalized as the moment at which awareness of an urge or decision to act arises. Measuring this moment has been challenging due to the dependence on first-person reports of subjective experience rather than ...
Ceci Verbaarschot   +2 more
doaj   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

open access: yesFEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens   +8 more
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

open access: yesMolecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat   +8 more
wiley   +1 more source

People's Charter for Health (2000)

open access: yesSocial Medicine
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Peoples' Health Movement
doaj  

Movement Lab Fellows Lunchtime Presentations: Maxime Cavajani

open access: yes, 2023
FAV will be holding lunchtime presentations of work by the Movement Lab Fellows throughout November. Mark your calendars for Movement Lab Fellow 23/24 Maxime Cavajani\u27s presentation on November 14th, 2023 @ 12pm in the Blue Studio (AUD 125).
Movement Lab,, Cavajani, Maxime
core  

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

open access: yesMolecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Humpback Whale Movements and Behavior in Response to Whale-Watching Vessels in Juneau, AK

open access: yesFrontiers in Marine Science, 2019
The whale-watching industry in Juneau, Alaska relies primarily on the presence of North Pacific humpback whales (Megaptera novaeangliae). To meet demands from the rapidly growing tourism industry, the number of whale-watching vessels in this region has ...
Alicia R. Schuler   +7 more
doaj   +1 more source

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