Results 61 to 70 of about 1,543,813 (309)

New Approaches to Old Questions in Gun Scholarship [PDF]

open access: yes, 2015
Reviewing Philip J. Cook and Kristin A. Gross, The Gun Debate: What Everyone Needs to Know; Saul Cornell and Nathan Kozuskanich, The Second Amendment on Trial: Critical Essays on District of Columbia v.
Blocher, Joseph
core   +2 more sources

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova   +25 more
wiley   +1 more source

Electromyographic comparison of the barbell deadlift using constant versus variable resistance in healthy, trained men.

open access: yesPLoS ONE, 2019
Variable, external resistance is proposed to increasingly augment the muscular stress throughout a dynamic movement. However, it is uncertain how different levels of variable resistance affect the activation in the deadlift.
Vidar Andersen   +6 more
doaj   +1 more source

Conformational Changes in the Metallo-β-lactamase ImiS During the Catalytic Reaction: An EPR Spectrokinetic Study of Co(II)-Spin Label Interactions [PDF]

open access: yes, 2008
Metallo-β-lactamases are responsible for conferring antibiotic resistance on certain pathogenic bacteria. In consequence, the search for inhibitors that may be useful in combating antibiotic resistance has fueled much study of the active sites of these ...
Bennett, Brian   +3 more
core   +2 more sources

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

open access: yesMolecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson   +9 more
wiley   +1 more source

Effects of Laryngeal Restriction on Pharyngeal Peristalsis and Biomechanics: Clinical Implications [PDF]

open access: yes, 2016
To date, rehabilitative exercises aimed at strengthening the pharyngeal muscles have not been developed due to the inability to successfully overload and fatigue these muscles during their contraction, a necessary requirement for strength training.
Balasubramanian, Gokulakrishnan   +5 more
core   +2 more sources

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

open access: yesMolecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos   +6 more
wiley   +1 more source

Shear resistance of rubber-ballast composites in simulated water and acid soaked conditions [PDF]

open access: yes, 2016
Ballast is one of the main structures for the railway tracks. It can resist the lateral movement under dynamic loading transferred by the passing trains with repeatedly.
Chan, Chee Ming, SM Johan, Siti Farhanah
core   +4 more sources

Critical Facets of European Corn Borer Adult Movement Ecology Relevant to Mitigating Field Resistance to Bt-Corn

open access: yesInsects
The European corn borer (Ostrinia nubilalis, Hübner) has been managed successfully in North America since 1996 with transgenic Bt-corn. However, field-evolved resistance to all four available insecticidal Bt proteins has been detected in four provinces ...
Thomas W. Sappington
doaj   +1 more source

Jordanian policy toward the Islamic Resistance Movement – Hamas 1990-2010 [PDF]

open access: yesدراسات أقليمية, 2013
Constitute the Palestinian issue key factor in policy Jordanian Foreign as well as a link Jordan outputs that case, whether that is compatible with their interests or that conflict with those interests regionally and internationally, and here was based ...
Fawaz Mowafaq Thanoon
doaj   +1 more source

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