Results 201 to 210 of about 487,695 (256)

Neurochemical Endpoints to Inform Early‐Stage Trials of Spinocerebellar Ataxia 2 and 3 in a Multisite Setting

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Neurochemical levels measured by brain MR spectroscopy (MRS) have been proposed as endpoints for clinical trials in early‐stage spinocerebellar ataxia (SCA) trials. We tested their trial‐readiness by quantifying neurochemicals in three affected brain regions in early‐stage cohorts of SCA2 and SCA3, examining their reproducibility in ...
James M. Joers   +19 more
wiley   +1 more source

Electroencephalographic Normalization as a Biomarker of Clinical Recovery in Down Syndrome Regression Disorder

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Down syndrome regression disorder is a syndrome characterized by subacute loss of cognitive, behavioral, and functional abilities in individuals with Down syndrome. Electroencephalography abnormalities are frequently observed during evaluation, but it remains unclear whether these findings represent a dynamic marker of disease ...
Jonathan D. Santoro   +14 more
wiley   +1 more source

T1 Over Squared Proton Density Ratio to Characterize Multiple Sclerosis Lesions

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Differentiating remyelinated from demyelinated lesions in MS remains challenging without histological confirmation. This study introduces the T1‐to‐PD2 ratio (TPR) imaging approach and evaluates its ability to characterize MS lesions alongside other quantitative MRI (qMRI) metrics. Methods Thirty individuals with MS (mean age: 47.5 ± 
Sarah J. Wright   +10 more
wiley   +1 more source

Moving Weighted Averages

Canadian Journal of Mathematics, 1993
AbstractLet ℝ denote the real line. Let {Tt}tєℝ be a measure preserving ergodic flow on a non atomic finite measure space (X, ℱ, μ). A nonnegative function φ on ℝ is called a weight function if ∫ℝ φ(t)dt = 1. Consider the weighted ergodic averagesof a function f X —> ℝ, where {θk} is a sequence of weight functions. Some sufficient and some necessary
Akcoglu, M. A., Déniel, Y.
openaire   +1 more source

Moving average separation

ICASSP-88., International Conference on Acoustics, Speech, and Signal Processing, 2003
A real symmetric polynomial Q(z) can be factored into the product A(z)A(z/sup -1/) if Q(z) is nonnegative on the unit circle. The authors pose a constrained minimization problem that results in the correct factorization in this case and gives an approximation to Q(z) if Q(z) does not satisfy the nonnegativity condition. >
German S. Feyh, Clifford T. Mullis
openaire   +1 more source

Averages on the Move

Mathematics Magazine, 1985
This note is concerned with how averages change when the items being averaged are transformed in a simple way. To make this more explicit we remind the reader of the definitions of four basic averages or means. Then we turn to a specific example, using the Celsius and Fahrenheit temperature scales to illustrate the problems involved.
Larry Hoehn, Ivan Niven
openaire   +1 more source

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