Results 51 to 60 of about 105,984 (266)

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

A Lagrangian particle model for one-dimensional transient pipe flow with moving boundary

Engineering Applications of Computational Fluid Mechanics
For simulating fluid transients in pipelines with moving water-air interface, a one-dimensional Lagrangian particle model with second-order accuracy in both space and time is proposed.
Yuejin Cai, Jianguo Wei, Qingzhi Hou, Huaicheng Fan, Arris S. Tijsseling   +4 more
doaj   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

A Stefan problem for composite materials with an arbitrary number of moving phase-transition boundaries

Учёные записки Казанского университета: Серия Физико-математические науки
A Stefan problem of heat transfer in semi-infinite bodies with an arbitrary number of unsteady moving boundaries during phase transitions was solved. Such problems arise when composite materials are heated at high temperatures, causing the binding agents
E. L. Kuznetsova, S. I. Zhavoronok
doaj   +1 more source

The possible mechanism for a frequency shift by a time-varying of medium features

Journal of Telecommunications and Information Technology, 2000
The optical frequency shift of an electromagnetic wave reflecting from a boundary of a medium is studies for two cases: for temporal variations of medium permittivity, and for a moving plasma boundary. It has been shown that a simultaneous occurrence of
Aleksander G. Nerukh, Marian Marciniak
doaj   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

A numerical method for a stefan-type problem

Mathematical Modelling and Analysis, 2011
A Stefan-type problem is considered. This is an initial-boundary value problem on a composite domain for a parabolic reaction-diffusion equation with a moving interface boundary.
G. Shishkin, L. Shishkina, K. Cronin
doaj   +1 more source