Results 81 to 90 of about 125,636 (269)
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
The effect of moving metal wall on microwave heating uniformity
四川大学学报. 自然科学版, 2017 In this paper, the phase of electromagnetic field distribution in the cavity is regulated through movements of the metal wall of a rectangular waveguide, which can avoid the inhomogeneous heating caused by the uneven distribution of electromagnetic field
ZHANG Chun +5 more
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Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
DYNAMIC RESPONSE OF PAVEMENT SUBJECTED TO MOVING LOAD
Structural Mechanics of Engineering Constructions and Buildings, 2015 The problem of dynamic equilibrium of the pavement under the action of moving load using ratios plane strain viscoelastic solid, resting on viscoelastic foundation is considered.
G L Kolmogorov +2 more
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Harnack Type Inequality: the Method of Moving Planes [PDF]
Communications in Mathematical Physics, 1999 Let \((M,g)\) be a compact Riemann surface without boundary and let \(\Delta_{g}\) be the associated Laplace-Beltrami operator. The main purpose of the paper is to provide a careful analysis of blowup solutions \((\xi_{n})\) in \(C^{2}(M)\) to the problems \[ - \Delta_{g} \xi_{n} = \lambda_{n} (V_{n} e^{\xi_{n}} - W_{n}) \quad\text{on \(M\)} , \qquad ...
openaire +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Optimal Coordinated Motions of Multiple Agents Moving on a Plane
SIAM Journal on Control and Optimization, 2003 The authors examine the problem of optimal coordinated motions of multiple agents moving in the same planar region. The objective is to determine the conflict-free maneuvers (motions) with the least combined energy and taking into account the different priorities of the agents.
J. Hu, PRANDINI, MARIA, S. Sastry
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Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
A Liouville Theorem for Nonlocal Equations in the Heisenberg Group
Bruno Pini Mathematical Analysis Seminar, 2014 We establish a Liouville-type theorem for a subcritical nonlinear problem, involving a fractional power of the sub-Laplacian in the Heisenberg group. To prove our result we will use the local realization of fractional CR covariant operators, which can be
Eleonora Cinti
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