Results 121 to 130 of about 6,255,622 (297)
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
FPGA-Based Real-Time Moving Target Detection System for Unmanned Aerial Vehicle Application
International Journal of Reconfigurable Computing, 2016 Moving target detection is the most common task for Unmanned Aerial Vehicle (UAV) to find and track object of interest from a bird’s eye view in mobile aerial surveillance for civilian applications such as search and rescue operation.
Jia Wei Tang +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
Spatial biology in cancer epigenetics
Molecular Oncology, EarlyView.Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley +1 more source
Slow Moving Target Detection Based on Deep Self-coding Network [PDF]
Jisuanji gongcheng, 2018 The slow target detection in the background of strong clutter has such problems as low Doppler frequency shift,clutter interference,lack of robustness,feature extraction difficulties and inadequate information utilization.Therefore,a target detection ...
LIU Kai,LIN Jiming,ZHENG Lin,YANG Chao
doaj
ADP‐ribosylation: An emerging regulator of the epigenome
Molecular Oncology, EarlyView.ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho +2 more
wiley +1 more source
Moving object detection using registration for a moving camera platform [PDF]
, 2012 In this research work, an accurate and fast moving object detector that can detect all the moving objects from Unmanned Aerial Platform (UAV) is proposed.
Cheraghi, Seyed Ali
core
A Macro-Pulse Photon Counting Lidar for Long-Range High-Speed Moving Target Detection. [PDF]
Sensors (Basel), 2020 Yu Y, Liu B, Chen Z, Li Z.
europepmc +1 more source
Molecular Oncology, EarlyView.We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee +3 more
wiley +1 more source