Results 51 to 60 of about 22,588 (167)

Altered Sigmoid Mucosal Innervation and Mast Cell Proximity to Sensory Nerve Fibers Are Associated With Symptom Severity in Patients With Irritable Bowel Syndrome

open access: yesNeurogastroenterology &Motility, Volume 37, Issue 12, December 2025.
3D imaging of nerve fibers and mast cells double‐labeled with antibodies against Substance P (SP, red) and tryptase (green) on CLARITY‐cleared human sigmoid colonic mucosal biopsies from an IBS patient. (A). Their spatial proximity was computationally quantified using Imaris 9.7 software (B), which demonstrated a significant positive correlation with ...
Pu‐Qing Yuan   +7 more
wiley   +1 more source

Efficacy and safety of electrical moxibustion for knee osteoarthritis: study protocol for a randomized controlled trial

open access: yesTrials, 2018
Background Knee osteoarthritis (KOA) is a significant health issue because it causes pain and functional limitation. Many studies have reported that moxibustion, a treatment in traditional Korean medicine, is effective in treating KOA.
Ha-Ra Kang   +5 more
doaj   +1 more source

Genetic Liability to Bone Mineral Density and Functional Outcome After Ischemic Stroke

open access: yesBrain and Behavior, Volume 15, Issue 11, November 2025.
Abstract Background and Objectives An increasing amount of research indicates that bone mineral density (BMD) could impact the functional outcome after ischemic stroke (FOAIS). However, the specific connection between BMD and FOAIS is still not clear. Hence, we utilized the Mendelian randomization method to examine the genetic predisposition to BMD in ...
Daofeng Fan   +5 more
wiley   +1 more source

Beyond tumour suppression: cGAS‐STING pathway in urologic malignancies: Context‐dependent duality and therapeutic implications

open access: yesClinical and Translational Medicine, Volume 15, Issue 11, November 2025.
The context‐dependent duality of cGAS–STING signalling in urologic tumours is revealed. Targeting the STING pathway, in combination with immunotherapies and gene therapies, enhances the anti‐tumour response. Sex hormone differences in urological malignancies are correlated with the cGAS–STING pathway.
Qi Wei   +4 more
wiley   +1 more source

Altered Topology of Brain Structural Network in Patients With Migraine Without Aura: A Structural MRI Study

open access: yesEuropean Journal of Pain, Volume 29, Issue 10, November 2025.
ABSTRACT Background Migraine is a neurovascular disease associated with significant morbidity and disability, but its underlying pathophysiology remains elusive. Functional alterations within the brain are frequently observed in individuals with migraine, whereas structural changes are less frequently documented.
Zi‐Min Cao   +11 more
wiley   +1 more source

Moxibustion ameliorates abnormal subchondral bone remodeling by promoting ACSL1-mediated autophagy to degrade NLRP3 in osteoarthritis

open access: yesChinese Medicine
Background Osteoarthritis (OA) is a joint disorder that is characterized, among other features, by abnormal subchondral bone remodeling. Moxibustion, a traditional Chinese medicine treatment, has a long history in the clinical treatment of osteoarthritis
Xuelan Chen   +6 more
doaj   +1 more source

Acupuncture for induction of labor in uncomplicated term pregnancies and the role of the acupoint selection: A systematic review and meta‐analysis

open access: yesActa Obstetricia et Gynecologica Scandinavica, Volume 104, Issue 11, Page 2038-2053, November 2025.
This systematic review and meta‐analysis evaluated the effects of acupuncture for labor induction after 37 weeks of gestation, with a focus on different acupoint selection strategies. No significant improvements were found in labor progression or birth outcomes compared to sham acupuncture or usual care; the certainty of evidence ranged from very low ...
An Chen   +7 more
wiley   +1 more source

Single‐Cell Transcriptomics Identifies Novel Prognostic Signatures in HNSCC Immunotherapy Response

open access: yesCancer Science, Volume 116, Issue 11, Page 2959-2971, November 2025.
This study demonstrates the value of combining single‐cell and bulk RNA sequencing approaches to understand HNSCC tumor biology and treatment response. The developed prognostic model and identified immune signatures provide a foundation for improving patient stratification and treatment selection.
Kankui Wu   +8 more
wiley   +1 more source

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