Results 161 to 170 of about 3,761 (208)
Treatment of small lungworm infestation in sheep by using moxidectin
Veterinary Parasitology, 2004 The use of moxidectin (MXD) in the treatment of small lungworm infestation (Cystocaulus ocreatus, Muellerius capillaris, Neostrongylus linearis and Protostronglylus rufescens) in sheep, was evaluated.
Elias Papadopoulos, George C Fthenakis
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European Journal of Pharmaceutical Sciences, 2006 International audienceMoxidectin, a macrocyclic lactone (ML), is a potent parasiticide widely used in veterinary medicine and currently under development for use in humans.
Anne Lespine +2 more
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Moxidectin: an oral treatment for human onchocerciasis [PDF]
Expert Review of Anti-Infective Therapy, 2020 Moxidectin is a milbemycin endectocide recently approved for the treatment of human onchocerciasis. Onchocerciasis, earmarked for elimination of transmission, is a filarial infection endemic in Africa, Yemen, and the Amazonian focus straddling Venezuela and Brazil.
Philip Milton +2 more
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Pharmacokinetics of moxidectin and doramectin in goats
Research in Veterinary Science, 1999The pharmacokinetic behaviour of doramectin after a single subcutaneous administration and moxidectin following a single subcutaneous or oral drench were studied in goats at a dosage of 0.2 mg kg(-1). The drug plasma concentration-time data were analysed by compartmental pharmacokinetics and non-compartmental methods.
Escudero, E. +5 more
openaire +3 more sources
Moxidectin induces autophagy arrest in colorectal cancer
Medical Oncology, 2022Colorectal cancer (CRC) is a cancer with a high morbidity and mortality worldwide. Hence, developing new therapeutic drugs for CRC is very important. Moxidectin (MOX) has shown good anti-glioblastoma effect both in vitro and in vivo. This study aimed to elucidate the anti-CRC effect of MOX and its potential mechanism by investigating the influence of ...
Yushan Mao +5 more
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Responsible use of moxidectin in sheep
Veterinary Record, 2020SCOPS (sustainable control of parasites in sheep) and Zoetis held a joint workshop in September 2019 to discuss how to advise prescribers and sheep farmers on the use of moxidectin, and prioritising the 2 per cent injectable formulation. This was in response to concerns regarding reports of potential overuse, in particular, as a treatment for ewes at ...
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Journal of Agricultural and Food Chemistry, 1994
The absorption, tissue distribution, excretion, and biotransformation of moxidectin, a novel endectocide that combats internal and external parasites in sheep, cattle, and horse, were studied in sheep. Following a single oral administration of a 1:1 mixture of 14 C- and deuterium-labeled moxidectin at 0.2 mg/g of body weight, the highest residue ...
Jalees Afzal +3 more
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The absorption, tissue distribution, excretion, and biotransformation of moxidectin, a novel endectocide that combats internal and external parasites in sheep, cattle, and horse, were studied in sheep. Following a single oral administration of a 1:1 mixture of 14 C- and deuterium-labeled moxidectin at 0.2 mg/g of body weight, the highest residue ...
Jalees Afzal +3 more
openaire +1 more source
Clinical trial of moxidectin oral gel in horses
Veterinary Parasitology, 1997A clinical trial carried out over 98 days was done to evaluate treatment of horses with moxidectin gel for efficacy as measured by (1) reduction in the production of parasite ova post treatment, (2) a comparison of the posttreatment parasite egg count suppression of moxidectin to ivermectin, and (3) assessment of the field safety, animal acceptance of ...
J A Dipietro
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Analytical Profile of Moxidectin
2013Moxidectin or F28249α is a potent endectocide and semisynthetic methoxime derivative of naturally occurring nemadectin. It is well known for the novel mode of action against a broad range of nematode and anthropod animal parasites. In this work, physicochemical and pharmaceutical aspects of moxidectin are described including stability, semisynthesis ...
Atul, Awasthi +4 more
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Safety of moxidectin in avermectin-sensitive Collies
American Journal of Veterinary Research, 2000Abstract Objective—To evaluate the safety of moxidectin administration at doses of 30, 60, and 90 µg/kg of body weight (10, 20, and 30 times the manufacturer's recommended dose) in avermectin-sensitive Collies. Animals—24 Collies. Procedure—Collies with mild to severe reactions to ivermectin challenge (120 mg/kg; 20 times ...
A J, Paul +2 more
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