Results 71 to 80 of about 4,217 (163)

Koyunlarda Doğal Psoroptes Ovis Uyuzunun Moxidectin ile Sağaltımı

, 2003
Bu çalışmada yaşlan 2-6 yıl arasında değişen ve doğal Psoroptes ovis uyuzla enfekte 14 akkaraman koyununda moxidectin 'in % 1 'lik enjektable solüsyonunun tek ve çift uygulamalarının klinik etkileri araştırıldı.
Kozat, Süleyman, Değer, Serdar
core   +1 more source

Moxidectin steady state prior to inoculation protects cats from subsequent, repeated infection with Dirofilaria immitis

Parasites & Vectors, 2015
Background Infection of cats with Dirofilaria immitis causes seroconversion on antibody tests and pulmonary pathology, often without subsequent development of adult heartworms.
Susan E Little, Joe A Hostetler, Jennifer E Thomas, Keith L Bailey, Anne W Barrett, Kaylynn Gruntmeir, Jeff Gruntmeir, Lindsay A Starkey, Chris Basel, Byron L Blagburn   +9 more
doaj   +1 more source

Advancing Pharmacoequity in Low‐ and Middle‐Income Countries via Model Informed Drug Development

Clinical and Translational Science, Volume 19, Issue 5, May 2026.
ABSTRACT Across low‐ and middle‐income countries (LMICs) inequities in access to safe, effective medicines persist due to limited regulatory capacity, inadequate financing, and insufficient local data. Regulatory authorities are engaging with model‐informed drug development (MIDD), but uneven technical readiness and resource gaps limit uptake ...
Henry Enzama, Francis Williams Ojara, Ian S. Haworth, Sandra Cvijic, Catriona Waitt, Thaddeus H. Grasela   +5 more
wiley   +1 more source

Efficacy of a spot-on combination of fluralaner plus moxidectin (Bravecto® Plus) in cats following repeated experimental challenge with a field isolate of Ctenocephalides felis

Parasites & Vectors, 2019
Background A spot-on formulation of fluralaner plus moxidectin has been designed to provide long-term protection against fleas and ticks, prevent heartworm disease and treat gastrointestinal nematode infections in cats. The objective of this study was to
Petr Fisara, Frank Guerino, Fangshi Sun
doaj   +1 more source

Functional Characterization of the Cat and Dog Wild‐Type and Mutant MDR1 Carrier Proteins and Frequency of the MDR1 Gene Mutation in 800 Cats From Germany

Journal of Veterinary Pharmacology and Therapeutics, Volume 49, Issue 3, Page 237-256, May 2026.
ABSTRACT The ATP‐binding cassette transporter MDR1 P‐glycoprotein (syn. ABCB1) is an efflux carrier at the cell membrane that regulates drug absorption, distribution, and elimination. At the blood–brain barrier, MDR1 restricts brain entry of potentially neurotoxic drugs, such as ivermectin. In dogs and cats, MDR1 (syn.
Lisa Siegl, Mies Bethäuser, Daniela Nürnberger, Stefan Oswald, Andreas Moritz, Melanie Hamann, Joachim Geyer   +6 more
wiley   +1 more source

A randomized, blinded, controlled, multi-centered field study assessing the treatment of gastrointestinal nematode infections in cats with fluralaner plus moxidectin spot-on solution (Bravecto® Plus)

Parasites & Vectors, 2018
Background A spot-on formulation containing fluralaner (280 mg/ml) plus moxidectin (14 mg/ml) (Bravecto® Plus) was developed for the treatment of nematode infections as well as providing 12 weeks of protection against insect and acarine parasites in cats.
Nadja Rohdich, Eva Zschiesche, Oliver Wolf, Wolfgang Loehlein, Zvezdelina Kirkova, Petar Iliev, Dhimitër Rapti, Rezart Postoli, Balázs Capári, Róbert Farkas, Rainer K. A. Roepke   +10 more
doaj   +1 more source

Evolution of Ivermectin Resistance in the Nematode Model Caenorhabditis elegans: Critical Influence of Population Size and Altered Emodepside Efficacy

Evolutionary Applications, Volume 19, Issue 4, April 2026.
ABSTRACT The emergence and spread of anthelmintic resistance represent a major challenge for treating parasitic nematodes, threatening mass‐drug administration control programs in humans and zoonotic hosts. Currently, experimental evidence to understand the influence of management (e.g., treatment dose and frequency) and parasite‐associated factors (e ...
Jacqueline Hellinga, Barbora Trubenova, Jessica Wagner, Marc Borchert, Jürgen Krücken, Roland R. Regoes, Hinrich Schulenburg, Georg von Samson‐Himmelstjerna   +7 more
wiley   +1 more source

Acquired tolerance to ivermectin and moxidectin after drug selection pressure in the nematode Caenorhabditis elegans

, 2016
International audienceIvermectin and moxidectin are the most widely administrated anthelmintic macrocyclic lactones (MLs) to treat human and animal nematode infections. Their widespread and frequent use has led to high level of resistance to these drugs.
Alberich, Mélanie, Menez, Cécile, Kansoh, Dalia, Lespine, Anne, Blanchard, Alexandra   +4 more
core   +1 more source

The use of quantitative clinical pharmacology approaches to support moxidectin dosing recommendations in lactation.

PLoS Neglected Tropical Diseases
Moxidectin is approved by the US Food and Drug Administration (US FDA) for the treatment of onchocerciasis (river-blindness) due to Onchocerca volvulus in patients aged 12 years and older.
Nolan D Wood, Danelle Smith, Sally A Kinrade, Mark T Sullivan, Craig R Rayner, David Wesche, Kashyap Patel, Karen Rowland-Yeo   +7 more
doaj   +1 more source

A pilot study on the potency of injectable vs. oral moxidectin formulation to suppress strongyle egg excretion in horses at twice lower dose

Helminthologia
The aim of present study was to examine the potency of moxidectin solution (Cydectin 1 %; Zoetis) and commercially available oral moxidectin gel (Equest®; Zoetis) to suppress the excretion of strongyle eggs in horses over a 6-week period.
Šarkūnas M., Schwahn A., Suleimanova K.   +2 more
doaj   +1 more source