Results 61 to 70 of about 3,761 (208)

Effect of multidrug resistance modulators on the activity of ivermectin and moxidectin against selected strains of Haemonchus contortus infective larvae

Pesquisa Veterinária Brasileira, 2001
Nematode parasites have shown resistance to the anthelmintics, ivermectin and moxidectin, and there is evidence that the over-expression of parasite P-glycoprotein (P-gp) may account, at least in part, for resistance to ivermectin.
Molento Marcelo B., Prichard Roger K.
doaj  

Pharmaco-toxicological Assessment of Antiparasitic Drug for Dogs and Cats "Gelmintal Mini Syrup"

Российский паразитологический журнал, 2020
The purpose of the research is conducting pharmaco-toxicological assessment of Gelmintal Mini Syrup based on a combination of moxidectin and toltrazuril. Materials and methods. The study was carried out on 64 white male rats and 40 white mice.
G. B. Arisova, M. V. Arisov, I. A. Stepanova, V. V. Khristenko   +3 more
doaj   +1 more source

Advancing Pharmacoequity in Low‐ and Middle‐Income Countries via Model Informed Drug Development

Clinical and Translational Science, Volume 19, Issue 5, May 2026.
ABSTRACT Across low‐ and middle‐income countries (LMICs) inequities in access to safe, effective medicines persist due to limited regulatory capacity, inadequate financing, and insufficient local data. Regulatory authorities are engaging with model‐informed drug development (MIDD), but uneven technical readiness and resource gaps limit uptake ...
Henry Enzama, Francis Williams Ojara, Ian S. Haworth, Sandra Cvijic, Catriona Waitt, Thaddeus H. Grasela   +5 more
wiley   +1 more source

Can mass drug administration of moxidectin accelerate onchocerciasis elimination in Africa?

, 2023
Epidemiological and modelling studies suggest that elimination of Onchocerca volvulus transmission (EoT) throughout Africa may not be achievable with annual mass drug administration (MDA) of ivermectin alone, particularly in areas of high endemicity and ...
Christine M. Halleux, Olipoh, G, Opoku, Nicholas O, Kinrade, Sally, Halleux, CM, Hopkins, A, Bakajika, DK, Walker, Martin, Annette C. Kuesel, Martin Walker, Nicholas O. Opoku, Milton, P, Hopkins, Adrian, Kuesel, Annette C, Milton, Philip, Kataliko, Kambale, Kuesel, AC, George Olipoh, Kanza, EM, Kura, Klodeta, Olipoh, George, Mumbere, Mupenzi, Simon K. Attah, Jonathan I. D. Hamley, Kennedy, Kambale Kasonia, Howard, Hayford, Kambale Kataliko, Kinrade, S, Hamley, Jonathan ID, Klodeta Kura, Mupenzi Mumbere, Howard, H, Mumbere, M, Basáñez, MG, Maurice M. Nigo, Attah, SK, Opoku, NO, Sampson Asare, Attah, Simon K, Halleux, Christine M, Philip Milton, Germain L. Mambandu, Asare, S, Walker, M, Kennedy, KK, Bakajika, Didier K, Hamley, JID, Mambandu, GL, Basáñez, Maria-Gloria, Nigo, Maurice M, Adrian Hopkins, Kataliko, K, Maria-Gloria Basáñez, Mambandu, Germain L, Didier K. Bakajika, Eric M. Kanza, Sally Kinrade, Nigo, MM, Kanza, Eric M, Hayford Howard, Kura, K, Asare, Sampson, Kambale Kasonia Kennedy   +62 more
core   +1 more source

Effectiveness of Anthelmintic Treatments in Small Ruminants in Germany

Animals, 2022
Widespread anthelmintic resistance is a concern for small ruminant health and production worldwide. The current situation regarding anthelmintic efficacy is, however, not very well studied in Germany.
Katja Voigt, Maximilian Geiger, Miriam Carmen Jäger, Gabriela Knubben-Schweizer, Christina Strube, Yury Zablotski   +5 more
doaj   +1 more source

Moxidectin: a review of chemistry, pharmacokinetics and use in horses [PDF]

Parasites & Vectors, 2009
This article reviews the current knowledge of the use of moxidectin (MOX) in horses, including its mode of action, pharmacokinetic and pharmacodynamic properties, efficacy, safety and resistance profile.Moxidectin is a second generation macrocyclic lactone (ML) with potent endectocide activity.
Cobb, Rami, Boeckh, Albert
openaire   +2 more sources

A comparative kinetic study of doramectin and moxidectin in zebu Gobra cattle (Bos indicus)

, 2008
International audienceThe plasma kinetics of doramectin and moxidectin were evaluated in zebu Gobra under field conditions after subcutaneous administration of 0.2 mg kg−1 of commercially available formulations for cattle.
Panguy, L.J., Bengone-Ndong, T., Mvouaka, S.K., Alvinerie, Roger, Kane, Y., Loudy-Moukédé, W.A.   +5 more
core   +1 more source

Moxidectin steady state prior to inoculation protects cats from subsequent, repeated infection with Dirofilaria immitis

Parasites & Vectors, 2015
Background Infection of cats with Dirofilaria immitis causes seroconversion on antibody tests and pulmonary pathology, often without subsequent development of adult heartworms.
Susan E Little, Joe A Hostetler, Jennifer E Thomas, Keith L Bailey, Anne W Barrett, Kaylynn Gruntmeir, Jeff Gruntmeir, Lindsay A Starkey, Chris Basel, Byron L Blagburn   +9 more
doaj   +1 more source

Efficacy of a spot-on combination of fluralaner plus moxidectin (Bravecto® Plus) in cats following repeated experimental challenge with a field isolate of Ctenocephalides felis

Parasites & Vectors, 2019
Background A spot-on formulation of fluralaner plus moxidectin has been designed to provide long-term protection against fleas and ticks, prevent heartworm disease and treat gastrointestinal nematode infections in cats. The objective of this study was to
Petr Fisara, Frank Guerino, Fangshi Sun
doaj   +1 more source

Evolution of Ivermectin Resistance in the Nematode Model Caenorhabditis elegans: Critical Influence of Population Size and Altered Emodepside Efficacy

Evolutionary Applications, Volume 19, Issue 4, April 2026.
ABSTRACT The emergence and spread of anthelmintic resistance represent a major challenge for treating parasitic nematodes, threatening mass‐drug administration control programs in humans and zoonotic hosts. Currently, experimental evidence to understand the influence of management (e.g., treatment dose and frequency) and parasite‐associated factors (e ...
Jacqueline Hellinga, Barbora Trubenova, Jessica Wagner, Marc Borchert, Jürgen Krücken, Roland R. Regoes, Hinrich Schulenburg, Georg von Samson‐Himmelstjerna   +7 more
wiley   +1 more source