Results 71 to 80 of about 754 (163)

Mitochondrial membrane Protein-Associated Neurodegeneration (MPAN): Pathophysiological characterization and pharmacological screening for potential therapies

, 2021
Neurodegeneration with Brain Iron Accumulation (NBIA) is a group of different rare disorders in which iron is accumulated in the brain, especially in the basal ganglia and substantia nigra. Prevalent symptoms are dystonia, spasticity and neuropsychiatric
Cilleros Holgado, Paula, Sánchez Alcázar, José Antonio, Munuera Cabeza, Manuel   +2 more
core  

Recommendations for developing, documenting, and distributing data products derived from NEON data

Ecosphere, Volume 16, Issue 1, January 2025.
Abstract The National Ecological Observatory Network (NEON) provides over 180 distinct data products from 81 sites (47 terrestrial and 34 freshwater aquatic sites) within the United States and Puerto Rico. These data products include both field and remote sensing data collected using standardized protocols and sampling schema, with centralized quality ...
Jeff W. Atkins, Kelly S. Aho, Xuan Chen, Andrew J. Elmore, Rich Fiorella, Wenqi Luo, Danica Lombardozzi, Claire Lunch, Leah Manak, Luis X. de Pablo, Allison N. Myers‐Pigg, Sydne Record, Tong Qiu, Samuel Reed, Benjamin Ruddell, Brandon Strange, Christa L. Torrens, Kelsey Yule, Andrew D. Richardson   +18 more
wiley   +1 more source

Atmospheric Fate of Methacrolein. 2. Formation of Lactone and Implications for Organic Aerosol Production [PDF]

, 2012
We investigate the oxidation of methacryloylperoxy nitrate (MPAN) and methacrylicperoxy acid (MPAA) by the hydroxyl radical (OH) theoretically, using both density functional theory [B3LYP] and explicitly correlated coupled cluster theory [CCSD(T)-F12 ...
Paulot, Fabien, Jørgensen, Solvejg, Knap, Hasse Christian, Hasse C. Knap, Solvejg Jørgensen, Crounse, John D., Knap, Hasse C., John D. Crounse, Ørnsø, Kristian B., Henrik G. Kjaergaard, Kristian B. Ørnsø, Fabien Paulot, Kjærgaard, Henrik Grum, Kjaergaard, Henrik G., Wennberg, Paul O., Paul O. Wennberg   +15 more
core   +1 more source

Expanded‐Access Use of Elamipretide Improves Quality of Life in Patients With Rare Mitochondrial Disorders Characterized by Ophthalmic Symptoms: A Case Series

Clinical Case Reports, Volume 12, Issue 12, December 2024.
ABSTRACT This case series presents the use of elamipretide in two patients with different progressive mitochondrial disorders (chronic progressive external ophthalmoplegia [CPEO] plus and neuropathy, ataxia, and retinitis pigmentosa [NARP] syndrome) characterized by ophthalmic traits.
Sharique Ansari, Mary Kay Koenig
wiley   +1 more source

Accurate and Efficient Numerical Simulation of Land Models Using SUMMA With SUNDIALS

Journal of Advances in Modeling Earth Systems, Volume 16, Issue 12, December 2024.
Abstract Numerical simulation of land models without error control can be highly inaccurate. We present the incorporation of the Suite of Nonlinear and Differential‐Algebraic Equation Solvers (SUNDIALS) package to solve the equations that simulate thermodynamics and hydrologic processes in the Structure for Unifying Multiple Modeling Alternatives ...
Raymond J. Spiteri, Ashley E. Van Beusekom, Kyle Klenk, Reza Zolfaghari, Sean J. Trim, Wouter J. M. Knoben, Andrew M. Ireson, Martyn P. Clark   +7 more
wiley   +1 more source

Canine RNF170 Single Base Deletion in a Naturally Occurring Model for Human Neuroaxonal Dystrophy

Movement Disorders, Volume 39, Issue 11, Page 2049-2057, November 2024.
We describe a new adult‐onset neurodegenerative disease in dogs, clinically exhibiting slowly progressive ataxia and histopathologically characterized as neuroaxonal dystrophy. Genetic analyses identified a 1‐bp (base pair) deletion in RNF170 revealing that these dogs represent a naturally occurring model for autosomal recessive spastic paraplegia 85 ...
Shawna R. Cook, Cleo Schwarz, Julien Guevar, Charles‐Antoine Assenmacher, Maeve Sheehy, Nathan Fanzone, Molly E. Church, Leonardo Murgiano, Margret L. Casal, Vidhya Jagannathan, Rodrigo Gutierrez‐Quintana, Mark Lowrie, Frank Steffen, Tosso Leeb, Kari J. Ekenstedt   +14 more
wiley   +1 more source

High‐Density Arrangement of Biomimetic Plasmonic Nanoprobes Guided by DNA Nanoroller based Cleaving‐Rolling Process for SERS Sensing Analysis

Advanced Functional Materials, Volume 34, Issue 44, October 29, 2024.
Inspired by the high efficiency of agricultural co‐operative machinery, a unique cleaving‐rolling‐assembly integrated nanodevice (CRAIN) is developed. The design of the multi‐oriented walking DNA nanorollers and the high enhanced activity of the biomimetic SERS probes significantly improve the reaction rate and sensitivity of the sensing device ...
Xinlin Xu, Tiantian Li, Yue Liu, Yang Xu, Jingjing Zhao, Wenhan Chen, Yu Luo, Linping Han, Weiling Song, Richard (Chunhui) Yang, Peng He, Yichao Wang, Hong Zhou   +12 more
wiley   +1 more source

Reactive intermediates revealed in secondary organic aerosol formation from isoprene [PDF]

, 2009
Isoprene is a significant source of atmospheric organic aerosol; however, the oxidation pathways that lead to secondary organic aerosol (SOA) have remained elusive.
Kwan, Alan J., Surratt, Jason D., Flagan, Richard C, Eddingsaas, Nathan C., Loza, Christine L., Chan, ManNin, Wennberg, Paul O, Hersey, Scott P, Seinfeld, John H., Chan, Arthur W. H., Hersey, Scott P., Chan, Arthur W.H., Flagan, Richard C., Wennberg, Paul O., Seinfeld, John H   +14 more
core   +1 more source

Insights Into the Influence of Anthropogenic Emissions on the Formation of Secondary Organic Aerosols Based on Online Measurements

Journal of Geophysical Research: Atmospheres, Volume 129, Issue 18, 28 September 2024.
Abstract To investigate the combined impacts of anthropogenic and biogenic emissions on the formation of secondary organic aerosols (SOA), SOA molecular tracers, their corresponding volatile organic compound precursors, and other air pollutants were measured online during the winter and summer seasons of 2022 in an industrial city, Zibo, China.
Yanan Yi, Rui Li, Kun Zhang, Xudong Yang, Qing Li, Chunmei Geng, Hui Chen, Wen Yang, Jian Zhen Yu, Li Li   +9 more
wiley   +1 more source

Distinct pathogenesis in nonsystemic vasculitic neuropathy and microscopic polyangiitis

, 2017
Objective:To investigate the mechanisms of vasculitis in nonsystemic vasculitic neuropathy (NSVN) and microscopic polyangiitis (MPA), focusing on complement- and antineutrophil cytoplasmic antibody (ANCA)-associated pathogenesis.Methods:Sural nerve ...
Masahisa Katsuno, Yuichi Kawagashira, Masahiro Iijima, Gen Sobue, Mie Takahashi, Haruki Koike, Atsushi Hashizume, Shohei Ikeda   +7 more
core   +1 more source