Results 91 to 100 of about 251,071 (299)

Discovery of H2 Receptor Antagonists as Colistin Enhancers by Targeting Acid Stress Response

Advanced Science, EarlyView.
This study identifies YqgB as a key target for restoring colistin susceptibility in mcr‐positive pathogens under acidic conditions by remodeling phospholipid composition and reducing LPS modification. Deep learning‐based screening reveals H2 receptor antagonists as novel colistin adjuvants. Further investigations indicate that ranitidine and famotidine
Jinju Cai, Mengping He, Jianya Luo, Shuang Zhou, Tengyue Zhang, Jianing Li, Zhiqiang Wang, Yuan Liu   +7 more
wiley   +1 more source

Model predictive controllers for reduction of mechanical fatigue in wind farms

, 2015
We consider the problem of dispatching WindFarm (WF) power demand to individual Wind Turbines (WT) with the goal of minimizing mechanical stresses. We assume wind is strong enough to let each WTs to produce the required power and propose different closed-
Ferrari-Trecate, Giancarlo, Mancini, Simone, Riverso, Stefano, Sarzo, Fabio   +3 more
core  

The Rate of Short-Duration Gamma-Ray Bursts in the Local Universe

, 2018
Following the faint gamma-ray burst, GRB 170817A, coincident with a gravitational wave-detected binary neutron star merger at $d\sim40$ Mpc, we consider the constraints on a local population of faint short duration GRBs (defined here broadly as $T_{90}
Lamb, Gavin, Levan, Andrew, Mandhai, Soheb, Tanvir, Nial, Tsang, David   +4 more
core   +2 more sources

MPC for Stochastic Systems

, 2007
Stochastic uncertainty is present in many control engineering problems, and is also present in a wider class of applications, such as finance and sustainable development. We propose a receding horizon strategy for systems with multiplicative stochastic uncertainty in the dynamic map between plant inputs and outputs. The cost and constraints are defined
Cannon, M, Couchman, P, Kouvaritakis, B
openaire   +1 more source

Unraveling the Molecular Mechanisms Underlying Spontaneous Multipolar Mitosis Through CIN‐seq

Advanced Science, EarlyView.
Multipolar mitosis, a hallmark of chromosomal instability (CIN), drives tumor heterogeneity but is challenging to study in live cells. Using CIN‐seq, a single‐cell multiomics method, we profiled rare CIN events and identified mechanisms associated with viable multipolar mitosis, including PTEN attenuation, Rho GTPase‐driven cytokinesis failure, and ...
Pin‐Rui Su, Ting‐Chun Chou, Maria Teresa López‐Cascales, Junfeng Huang, Tsai‐Ying Chen, Sjoukje van Wieren, Chan Li, Cecile Beerens, Li You, Jelle Storteboom, Miao‐Ping Chien   +10 more
wiley   +1 more source

Evaluating the Utilities of Foundation Models in Single‐Cell Data Analysis

Advanced Science, EarlyView.
This study delivers the first systematic, task‐level evaluation of single‐cell foundation models across eight core analytical tasks. By benchmarking 10 leading models with the scEval framework, it reveals where foundation models truly add value, where task‐specific methods still dominate, and provides concrete, reproducible guidelines to steer the next
Tianyu Liu, Kexing Li, Yuge Wang, Hongyu Li, Hongyu Zhao   +4 more
wiley   +1 more source

LOCAL LINEARIZATION OF KERNEL MODELS IN REAL TIME AS A BASIS FOR FAST OPTIMIZATION IN MPC

Автоматизация технологических и бизнес-процессов
Magnetic separation of iron ore is a complex nonlinear process whose control requires accounting for transport delays, cross-coupling effects, and stochastic variability of raw materials.
O. Volovetskyi
doaj   +1 more source

Binary compact object coalescence rates: The role of elliptical galaxies

, 2010
We estimate binary compact object merger detection rates for LIGO, including the binaries formed in ellipticals long ago. Specifically, we convolve hundreds of model realizations of elliptical- and spiral-galaxy population syntheses with a model for ...
Abbott, Acernese, Adhikari, Ajith, Anderson, Belczynski, Belczynski, Belczynski, Belczynski, Belczynski, Belczynski, Belczynski, Bloom, Brown, Bulik, Bulik, Duquennoy, Fall, Fregeau, Fryer, Fryer, Hopman, Kalogera, Kopparapu, Kroupa, Krzysztof Belczynski, Landry, Li, Linden, Mandel, Mandel, Miller, Nagamine, Nelemans, O'Shaughnessy, O'Shaughnessy, O'Shaughnessy, O'Shaughnessy, O'Shaughnessy, Pfahl, Pooley, Portegies Zwart, Portegies Zwart, Postnov, Prochaska, R. O'Shaughnessy, Rasio, Rhoads, Sadowski, Troja, V. Kalogera, Virgili, Wang, Zemp, Zhang, Zheng   +55 more
core   +1 more source

Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy

Advanced Science, EarlyView.
Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong, Yuhang Xie, Zhijie Weng, Yongzhi Wu, Longjiang Li, Bo Li   +5 more
wiley   +1 more source

Single‐Cell Transcriptomics Reveals FLS2‐Dependent Hypoxia Signaling and ERF13‐Mediated Transcription During flg22‐Triggered Immunity

Advanced Science, EarlyView.
This study employs sc‐RNA sequencing, genetics, and phenotyping to systematically map the cell‐type‐specific immune responses triggered by flg22. It reveals FLS2‐dependent transcriptional reprogramming in epidermal and mesophyll cells, and uncovers crosstalk between immune and hypoxia signaling pathways.
Yaping Zhou, Aizhi Qin, Mengfan Li, Qianli Zhao, Luyao Kong, Lulu Yan, Chunyang Li, Hao Liu, Yinpeng Zhang, Jiani Long, Mengyu Liao, Mengmeng Zhou, Xiaoli Fan, Baozhen Wang, Wenxuan Kang, Shui Wang, Zhixin Liu, Xuwu Sun   +17 more
wiley   +1 more source