Results 251 to 260 of about 36,802 (283)
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Increasing therapeutic efficacy in MPN
Blood, 2014In this issue of Blood, Bhagwat et al describe an elegant series of experiments showing that genetic deletion in the hematopoietic system of Janus kinase 2 (JAK2) abrogates initiation of myeloproliferative disease and substantial disease regression if deleted once disease is initiated.
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Myeloproliferative Neoplasm (MPN)
2020MPNs comprise various groups of clonal hematopoietic stem cell disorders. The WHO classification 2017 subdivides MPNs into BCR-ABL1-positive chronic myeloid leukaemia (CML) and BCR-ABL1-negative or Philadelphia (Ph) chromosome negative MPNs.
Christine Beham-Schmid +1 more
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Myeloproliferative Neoplasien (MPN)
Der Klinikarzt, 2018ZusammenfassungMyeloproliferative Neoplasien (MPN) sind klonale Stammzellerkrankungen, die typischerweise mit der Vemehrung einer oder mehrerer Blutzellreihen, einer Knochenmarkhyperplasie und einer (Hepato)-Splenomegalie als Zeichen der extramedullären Hämatopoese einhergehen. Gefürchtete Komplikationen der MPN sind
Steffen Koschmieder, Tim H. Brümmendorf
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Blood, 2009
In this issue of Blood, Ishii and colleagues investigate the role of mast cells in the pathogenesis of pruritus in patients with MPNs.
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In this issue of Blood, Ishii and colleagues investigate the role of mast cells in the pathogenesis of pruritus in patients with MPNs.
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Myeloproliferative Neoplasms (MPNs)
2021Myeloproliferative neoplasms are characterized by a clonal proliferation of one or more hematopoietic cell lineages, predominantly in the bone marrow but sometimes in the liver and spleen. In contrast to MDS, they show terminal myeloid cell expansion into the peripheral blood. They include CML, chronic neutrophilic leukemia (CML) polycythemia vera (PV),
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MPN-associated myelofibrosis (MPN-MF)
Leukemia Research, 2011R A, Mesa +5 more
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Myeloproliferative Neoplasien (MPN)
2013Unter den myeloproliferativen Neoplasien nimmt die chronische myeloische Leukamie (CML) eine besondere Stellung ein, da bei ihr erstmalig bei einem Tumor eine spezifische Chromosomenaberration, die Philadelphia-Translokation t(9;22) mit dem Fusionsgen BCR-ABL1 gefunden wurde. Hierdurch ist diese Krankheit definiert und von ahnlichen Erkrankungen scharf
Helmut Löffler, Torsten Haferlach
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MPN Fitness: A Single-Cell, Single-Tube Measurement of the Pathobiology of MPNs
BloodIntroduction: Myeloproliferative neoplasms (MPNs) are characterized by shortened survival due to thrombosis and progression to myelofibrosis and acute leukemia. Meaningful improvement in the care of patients requires therapies that prolong event-free survival (EFS); however, validated monitoring ...
Franco Castillo Tokumori +5 more
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