Results 51 to 60 of about 5,276 (179)

Protein Tyrosine Phosphatase Receptor S Acts as a Metastatic Suppressor in Malignant Peripheral Nerve Sheath Tumor via Profilin 1-Induced Epithelial-Mesenchymal Transition

Frontiers in Cell and Developmental Biology, 2020
Malignant peripheral nerve sheath tumors (MPNST) are aggressive sarcomas with over half of cases developed in the context of neurofibromatosis type 1. Surgical resection is the only effective therapy for MPNST.
Jie-Yi Ren, Yi-Hui Gu, Xi-Wei Cui, Man-Mei Long, Wei Wang, Cheng-Jiang Wei, Bin Gu, Hai-Bing Zhang, Qing-Feng Li, Zhi-Chao Wang   +9 more
doaj   +1 more source

A subset of high‐grade sarcomas with myogenic differentiation are associated with recurrent FGFR fusions

The Journal of Pathology: Clinical Research, Volume 12, Issue 4, July 2026.
Abstract Recurrent fusions involving FGFR1‐4 genes have been previously described in rare subsets of mostly benign chondroid and mesenchymal neoplasms involving bone and soft tissue. However, a more comprehensive analysis of sarcomas associated with FGFR fusions, including their incidence and histotypes, has not been performed.
Maximus CF Yeung, Carla Saoud, Sarah Chiang, Meera Hameed, Cristina R Antonescu   +4 more
wiley   +1 more source

Malignant peripheral nerve sheath tumour (MPNST)

Oncology in Clinical Practice, 2019
MPNST is a malignant neoplasm of peripheral nerves, usually arising in connection with nerve trunks of the limbs and torso. It can develop de novo or on the basis of an already existing neurofibroma. Such tumours constitute about 5% of soft tissue sarcomas. In 90%, they occur in patients in the 2–5 decade of life.
Czarnecka, Anna, Paweł Sobczuk, Zdzienicki, Marcin, Spałek, Mateusz, Rutkowski, Piotr   +4 more
openaire   +2 more sources

Huge Intrathoracic Malignant Peripheral Nerve Sheath Tumor in an Adolescent with Neurofibromatosis Type 1

Case Reports in Pediatrics, 2014
Malignant peripheral nerve sheath tumor (MPNST) is a rare soft tissue malignancy usually found in patients with neurofibromatosis type 1 (NF1) with a poor outcome. Although MPNST can be found in any part of the body including head and neck or extremities,
Jong Hyung Yoon, Hyun-Sung Lee, Jong In Chun, Seog-Yun Park, Hyeon Jin Park, Byung-Kiu Park   +5 more
doaj   +1 more source

A living biobank of sarcoma patient‐derived cell cultures reveals multi‐omic and functional insights that capture disease heterogeneity

Clinical and Translational Medicine, Volume 16, Issue 7, July 2026.
Preclinical models for sarcoma that preserve tumour biology are urgently needed to advance mechanistic understanding and functional precision oncology. 29 early‐passage patient‐derived sarcoma cell (PDC) cultures from 19 patients, representing 11 sarcoma subtypes were established and extensively characterized.
Stefanie Gijsels, Suzanne Fischer, David Creytens, Sándor Dedeyne, Felix De Vuyst, Cláudio Pinheiro, Fleur Cordier, Sarah‐Lee Bekaert, Nadine Van Roy, Kaat Durinck, Jarne Pauwels, Kris Gevaert, Pieter Mestdagh, Jo Vandesompele, Pekka Rappu, Jyrki Heino, An Hendrix, Gabrielle H. van Ramshorst, Gwen Sys, Olivier De Wever   +19 more
wiley   +1 more source

Skull Base Surgery in the Pediatric Population—The 2nd International Collaborative Study (1995–2015)

Head &Neck, Volume 48, Issue 7, Page 1742-1754, July 2026.
ABSTRACT Background The current study presents the efforts of a global collaborative group to review the management and outcomes of malignant tumors of the skull base in the pediatric population worldwide. Patients and Methods A total of 28 institutions contributed data on 3061 patients. From this, there were 64 pediatric patients (2.1%).
Dan M. Fliss, Omer J. Ungar, Helena Levyn, Cristina Valero, Dauren Adilbay, Alana Eagan, Junting Zheng, Mithat Gonen, Marc A. Cohen, Snehal Patel, Ian Ganly, Prathamesh Pai, Paolo Castelnuovo, Fang Ju Gao, Cesare Piazza, Piero Nicolai, Benedict J. Panizza, James Bowman, Catherine Barnett, Luiz P. Kowalski, Ronaldo N. Toledo, John DeAlmeida, Ian Witterick, Philippe Herman, Walter Fontanella, Gregorio Sanchez Aniceto, Sefik Hosal, Serdar Ozer, Subramania Iyer, Richard Harvey, C. Rene Leemans, Jan‑Jaap Hendrickx, Marcelo Figari, Luis Boccalatte, Ichi Nibu, Peter Clarke, Catherine Rennie, Yiming Zhu, Claudio Cernea, Sergio Goncalves, Rodney Schlosser, Fernando Dias, Zoukaa Sargi, Shahzada Ahmed, Wojciech Golusinski, Se Heon Kim, Shirley Y. Su, Shaan M. Raza, Franco DeMonte, Ehab Hanna, Jatin P. Shah   +50 more
wiley   +1 more source

Factors Within the Endoneurial Microenvironment Act to Suppress Tumorigenesis of MPNST [PDF]

Frontiers in Cellular Neuroscience, 2018
Background: Deciphering avenues to adequately control malignancies in the peripheral nerve will reduce the need for current, largely-ineffective, standards of care which includes the use of invasive, nerve-damaging, resection surgery. By avoiding the need for en bloc resection surgery, the likelihood of retained function or efficient nerve regeneration
Jo Anne Stratton, Jo Anne Stratton, Jo Anne Stratton, Peggy Assinck, Peggy Assinck, Sarthak Sinha, Ranjan Kumar, Aaron Moulson, Natalya Patrick, Eko Raharjo, Jennifer A. Chan, Jennifer A. Chan, Rajiv Midha, Wolfram Tetzlaff, Jeff Biernaskie, Jeff Biernaskie, Jeff Biernaskie   +16 more
openaire   +3 more sources

Metastatic Testicular Germ Cell Tumor in a Patient With Neurofibromatosis Type 1: Treatment With Trametinib Based on NF1 Gene Mutation

IJU Case Reports, Volume 9, Issue 4, July 2026.
ABSTRACT Introduction Neurofibromatosis type 1 (NF1) is a genetic disorder that increases the risk of various tumors. However, its association with testicular germ cell tumors (GCTs) is rare. We report a case of metastatic GCT in an NF1 patient treated with precision medicine.
Keita Goto, Toshiki Kijima, Yusuke Sato, Kousuke Watanabe, Hidenori Kage, Katsutoshi Oda, Tatsunori Shimoi, Kazuyuki Ishida, Haruki Kume, Takao Kamai   +9 more
wiley   +1 more source

Complete Resection of a Middle Mediastinal Malignant Peripheral Nerve Sheath Tumour via a Transmanubrial Osteomuscular Sparing Approach: A Case Report

Respirology Case Reports, Volume 14, Issue 7, July 2026.
We report a rare middle mediastinal malignant peripheral nerve sheath tumour. Preoperative imaging showed contact with vital structures, raising concern for resectability. However, complete resection was achieved using a transmanubrial osteomuscular sparing approach.
Minoru Sugihara, Shota Nakamura, Heng Huang, Taiki Ryo, Yoshito Imamura, Yasuhisa Ichikawa, Tatsuya Masuda, Hirofumi Takenaka, Hiroki Watanabe, Yuta Kawasumi, Keita Nakanishi, Yuka Kadomatsu, Harushi Ueno, Taketo Kato, Tetsuya Mizuno, Toyofumi Fengshi Chen‐Yoshikawa   +15 more
wiley   +1 more source

Surgical Treatment and Targeted Therapy for a Large Metastatic Malignant Peripheral Nerve Sheath Tumor: A Case Report and Literature Review

Life
Neurofibromatosis type 1 (NF1) significantly increases the risk of malignant peripheral nerve sheath tumors (MPNST), a rare and aggressive malignancy for which treatment is clinically challenging.
Patryk Skórka, Dawid Kordykiewicz, Andrzej Ilków, Konrad Ptaszyński, Janusz Wójcik, Wiktoria Skórka, Małgorzata Edyta Wojtyś   +6 more
doaj   +1 more source