Results 31 to 40 of about 5,276 (179)

suz12 inactivation in p53- and nf1-deficient zebrafish accelerates the onset of malignant peripheral nerve sheath tumors and expands the spectrum of tumor types

Disease Models & Mechanisms, 2020
Polycomb repressive complex 2 (PRC2) is an epigenetic regulator of gene expression that possesses histone methyltransferase activity. PRC2 trimethylates lysine 27 of histone H3 proteins (H3K27me3) as a chromatin modification associated with repressed ...
Felix Oppel, Dong H. Ki, Mark W. Zimmerman, Kenneth N. Ross, Ting Tao, Hui Shi, Shuning He, Jon C. Aster, A. Thomas Look   +8 more
doaj   +1 more source

Hypoxia-inducible factor 1 alpha is a poor prognostic factor and potential therapeutic target in malignant peripheral nerve sheath tumor. [PDF]

PLoS ONE, 2017
BACKGROUND:Malignant peripheral nerve sheath tumor (MPNST) is a rare soft tissue sarcoma with poor prognosis. Hypoxia-inducible factor 1 (HIF-1) plays a crucial role in the cellular response to hypoxia and regulates the expression of multiple genes ...
Suguru Fukushima, Makoto Endo, Yoshihiro Matsumoto, Jun-Ichi Fukushi, Tomoya Matsunobu, Ken-Ichi Kawaguchi, Nokitaka Setsu, Keiichiro IIda, Nobuhiko Yokoyama, Makoto Nakagawa, Kenichiro Yahiro, Yoshinao Oda, Yukihide Iwamoto, Yasuharu Nakashima   +13 more
doaj   +1 more source

Breast metastases from a malignant peripheral nerve sheath tumor of the kidney: An unusual presentation

Urology Annals, 2016
Malignant peripheral nerve sheath tumors (MPNSTs) are extremely rare soft tissue sarcomas of ectomesenchymal origin. They are commonly seen in association with neurofibromatosis type 1 (NF-1), but can also occur without a history of NF (isolated MPNST ...
Shalini Koppisetty, Ricardo C Alessio, Atul Rajpurkar   +2 more
doaj   +1 more source

Metabolische Untersuchungen lebender Zellen im Minutentakt, ermöglicht durch schnelle Parawasserstoff‐basierte Hyperpolarisation

Angewandte Chemie, Volume 138, Issue 34, 17 August 2026.
Die schnelle Parawasserstoff‐Hyperpolarisation in Kombination mit einfacher Verdünnung ermöglicht die Zufuhr von hyperpolarisiertem, biokompatiblen Pyruvats zu immobilisierten lebenden Zellen innerhalb von ≈1 min. Wiederholte Substratinjektionen offenbaren frequenzabhängige metabolische Dynamiken und eröffnen damit eine neue zeitliche Dimension für ...
Philipp R. Groß, Stefan Petersen, Zirun Wang, Behnam Shamshiri, Henri de Maissin, Sebastian Lucas, Oliver Gorka, Lisa Heß, Irene Marco‐Rius, Lluís Mangas‐Florencio, André F. Martins, Philipp Boehm‐Sturm, Maxim Zaitsev, Robert Zeiser, Jan‐Bernd Hövener, Thomas Reinheckel, Olaf Groß, Andreas B. Schmidt   +17 more
wiley   +1 more source

Discoidin domain receptor inhibitor DDR1-IN-1 induces autophagy and necroptotic cell death in malignant peripheral nerve sheath tumor

Cell Death Discovery
Malignant peripheral nerve sheath tumor (MPNST) is a soft tissue sarcoma commonly associated with the tumor-predisposition disorder neurofibromatosis 1. The extracellular matrix collagens contribute to many fibrotic tumors; however, the role of collagen ...
Guan-Yi Lai, Yu-Cheng Lee, Hao-Jui Weng, Kuei-Hung Lai, Min-Chen Hsiang, Kai-Yu Hsu, Chung-Ping Liao   +6 more
doaj   +1 more source

Intraosseous malignant peripheral nerve sheath tumor of distal femur detected with fluorine-18 fluorodeoxyglucose positron emission tomography/computed tomography imaging

Journal of Mahatma Gandhi Institute of Medical Sciences, 2016
Malignant peripheral nerve sheath tumor (MPNST) is a malignant soft tissue tumor arising from peripheral nerve sheath cells. MPNST is uncommon and can be associated with neurofibromatosis Type I (NF-I).
Koramadai Karuppusamy Kamaleshwaran, Firoz Rajan, Vyshakh Mohanan, Ajit Sugunan Shinto   +3 more
doaj   +1 more source

Cell-free DNA ultra-low-pass whole genome sequencing to distinguish malignant peripheral nerve sheath tumor (MPNST) from its benign precursor lesion: A cross-sectional study.

PLoS Medicine, 2021
BackgroundThe leading cause of mortality for patients with the neurofibromatosis type 1 (NF1) cancer predisposition syndrome is the development of malignant peripheral nerve sheath tumor (MPNST), an aggressive soft tissue sarcoma.
Jeffrey J Szymanski, R Taylor Sundby, Paul A Jones, Divya Srihari, Noah Earland, Peter K Harris, Wenjia Feng, Faridi Qaium, Haiyan Lei, David Roberts, Michele Landeau, Jamie Bell, Yi Huang, Leah Hoffman, Melissa Spencer, Matthew B Spraker, Li Ding, Brigitte C Widemann, Jack F Shern, Angela C Hirbe, Aadel A Chaudhuri   +20 more
doaj   +1 more source

Increased Risk of Sarcomas in Children With Congenital Anomalies: Findings From the Genetic Overlap Between Anomalies and Cancer in Kids (GOBACK) Registry Linkage Study

Pediatric Blood &Cancer, Volume 73, Issue 8, August 2026.
ABSTRACT Background Pediatric sarcomas are a heterogeneous group of tumors that contribute disproportionately to cancer mortality in children. Although congenital anomalies are among the strongest known risk factors for childhood cancer, the risk of specific sarcoma subtypes among affected individuals has not yet been thoroughly evaluated. Procedure We
Russ Wolters, Ji Yun Tark, Tiffany M. Chambers, Tania A. Desrosiers, Michael E. Scheurer, Charles Shumate, Wendy N. Nembhard, Mahsa M. Yazdy, Eirini Nestoridi, Amanda E. Janitz, Jean Paul Tanner, Russell S. Kirby, Jason L. Salemi, Yao Yu, Chad D. Huff, Sharon E. Plon, Philip J. Lupo, Jeremy M. Schraw   +17 more
wiley   +1 more source

Overexpression of cyclooxygenase-2 in malignant peripheral nerve sheath tumor and selective cyclooxygenase-2 inhibitor-induced apoptosis by activating caspases in human malignant peripheral nerve sheath tumor cells. [PDF]

PLoS ONE, 2014
BACKGROUND: Cyclooxygenase-2 (COX-2) is a key enzyme in the conversion of arachidonic acid to prostanoids, and its activation is associated with carcinogenesis as well as inflammation.
Michiyuki Hakozaki, Takahiro Tajino, Shinichi Konno, Shinichi Kikuchi, Hitoshi Yamada, Michiro Yanagisawa, Jun Nishida, Hiroyuki Nagasawa, Takashi Tsuchiya, Akira Ogose, Masafumi Abe, Hiroshi Hojo   +11 more
doaj   +1 more source

Deep genomic analysis of malignant peripheral nerve sheath tumor cell lines challenges current malignant peripheral nerve sheath tumor diagnosis

iScience, 2023
Summary: Malignant peripheral nerve sheath tumors (MPNSTs) are soft-tissue sarcomas of the peripheral nervous system that develop either sporadically or in the context of neurofibromatosis type 1 (NF1).
Miriam Magallón-Lorenz, Ernest Terribas, Sara Ortega-Bertran, Edgar Creus-Bachiller, Marco Fernández, Gerard Requena, Inma Rosas, Helena Mazuelas, Itziar Uriarte-Arrazola, Alex Negro, Tereza Lausová, Elisabeth Castellanos, Ignacio Blanco, George DeVries, Hiroyuki Kawashima, Eric Legius, Hilde Brems, Viktor Mautner, Lan Kluwe, Nancy Ratner, Margaret Wallace, Juana Fernández-Rodriguez, Conxi Lázaro, Jonathan A. Fletcher, David Reuss, Meritxell Carrió, Bernat Gel, Eduard Serra   +27 more
doaj   +1 more source