Results 141 to 150 of about 82,070 (285)

The impact of rectal spacers in MR-guided adaptive radiotherapy

Clinical and Translational Radiation Oncology
The use of stereotactic ablative radiotherapy (SABR) for prostate cancer has increased significantly. However, SABR can elevate the risk of moderate gastrointestinal (GI) side effects. Rectal spacers mitigate this risk by reducing the rectal dose. This study evaluates the impact of rectal spacers in MR-guided adaptive radiotherapy (MRgART) for prostate
Vikneswary Batumalai, David Crawford, Maddison Picton, Charles Tran, Urszula Jelen, Madeline Carr, Michael Jameson, Jeremy de Leon   +7 more
openaire   +3 more sources

Comparison of prostate delineation on multimodality imaging for MR-guided radiotherapy

The British Journal of Radiology, 2019
Objective:With increasing incorporation of MRI in radiotherapy, we investigate two MRI sequences for prostate delineation in radiographer-led image guidance.Methods:Five therapeutic radiographers contoured the prostate individually on CT, T  2 weighted (T  2W) and T  2* weighted (T  2*W) imaging for 10 patients.
Pathmanathan, AU, McNair, HA, Schmidt, MA, Brand, DH, Delacroix, L, Eccles, CL, Gordon, A, Herbert, T, van As, NJ, Huddart, RA, Tree, AC   +10 more
openaire   +3 more sources

Hypervision Proton Surgery: The Future Direction of Proton Therapy

iNew Medicine, EarlyView.
ABSTRACT Proton beams provide unique physical advantages characterized by a low entrance dose, negligible exit dose, and a sharp Bragg peak, which enable superior sparing of normal tissues and support safe dose escalation for improved tumor control. However, conventional photon‐based fractionation remains widely used in proton therapy, where prolonged ...
Li Li, Shuanghu Yuan
wiley   +1 more source

Temporal Interpolation via Motion Field Prediction

, 2018
Navigated 2D multi-slice dynamic Magnetic Resonance (MR) imaging enables high contrast 4D MR imaging during free breathing and provides in-vivo observations for treatment planning and guidance.
Karani, Neerav, Konukoglu, Ender, Tanner, Christine, Zhang, Lin   +3 more
core   +1 more source

Targeting GRP78 and the Proteostasis Network to Break the Therapeutic Ceiling in Neuroendocrine Prostate Cancer

iNew Medicine, EarlyView.
ABSTRACT HSPA5 (also known as GRP78/BiP) is a master regulator of the endoplasmic reticulum (ER) stress response and a key node in the proteostasis network. In neuroendocrine prostate cancer (NEPC), an aggressive, therapy‐refractory lineage that emerges under pressure from androgen receptor (AR) directed therapies, GRP78 is upregulated and co‐opted to ...
Amos Olalekan Akinyemi, Md Rakibul Alam, Mithu Howlader, Mohammad Esfini Farahani, Lixiang Gu, Chun Li, Chripus Ngule, Kevin Fulp, Bolaji Owoyemi, Xinyi Wang, Samuel Nwadialo, Fatemeh Selani, Makumba Esoe, Obaleye Oluwafunminiyi, Zhiguo Li   +14 more
wiley   +1 more source

An efficient and robust MRI-guided radiotherapy planning approach for targeting abdominal organs and tumours in the mouse.

PLoS ONE, 2017
IntroductionPreclinical CT-guided radiotherapy platforms are increasingly used but the CT images are characterized by poor soft tissue contrast. The aim of this study was to develop a robust and accurate method of MRI-guided radiotherapy (MR-IGRT ...
Veerle Kersemans, John S Beech, Stuart Gilchrist, Paul Kinchesh, Philip D Allen, James Thompson, Ana L Gomes, Zenobia D'Costa, Luke Bird, Iain D C Tullis, Robert G Newman, Aurelien Corroyer-Dulmont, Nadia Falzone, Abul Azad, Katherine A Vallis, Owen J Sansom, Ruth J Muschel, Borivoj Vojnovic, Mark A Hill, Emmanouil Fokas, Sean C Smart   +20 more
doaj   +1 more source

Motion Mitigation Techniques for Abdominal and Cardiac MR Imaging

Journal of Magnetic Resonance Imaging, EarlyView.
ABSTRACT MRI of the heart and abdominal organs provides unparalleled soft tissue contrast and quantitative biomarkers, yet remains highly susceptible to physiological motion. Contractions of the myocardium, respiratory excursions, peristalsis, vascular pulsatility, and unpredictable bulk patient movement generate artifacts that impair image quality ...
Eric M. Schrauben, Gastao Lima da Cruz, Christopher W. Roy, Thomas Küstner   +3 more
wiley   +1 more source

Quantitative Real‐Time MRI for the Assessment of Gastric Motility

Journal of Magnetic Resonance Imaging, EarlyView.
ABSTRACT Background Current reference standards for measuring gastric emptying and motility are not considered optimal due to the time required, ionizing radiation, invasiveness, and spatial resolution. Purpose To assess gastric motility using novel real‐time dynamic magnetic resonance imaging in combination with static measurements for gastric ...
Lydia Neubauer, Leonie Forstreuter, Fabian Winter, Fiona Mankertz, Mark O. Wielpütz, Donata S. Grajecki, Antje Steveling, Ali A. Aghdassi, Sebastian Zeißig, Matthew D. Blackledge, Dirk Voit, Jens Frahm, Susanne Schnell, Werner Weitschies, Linus Großmann   +14 more
wiley   +1 more source

Magnetic Resonance Guided Radiation Therapy (MRgRT) Prostate Motion and Margins

Journal of Medical Radiation Sciences, EarlyView.
This study evaluated intra‐fractional prostate motion during MR‐guided radiotherapy to determine appropriate PTV margins for prostate cancer. Analysis of 18 patients resulted in calculated margins of 3.2 mm (AP), 1.7 mm (LR), and 3.2 mm (SI), supporting the potential for margin reduction with MRgRT. ABSTRACT Introduction Systematic and random errors in
Sammi Peng, Tegan Courtot, Jessica Lye, Farshad Foroudi, Mark Tacey, Daryl Lim Joon, Michael Chao, Ee Siang Choong   +7 more
wiley   +1 more source

Stabilised Hyaluronic Acid Gel Rectal Spacers in MRI‐Guided Brachytherapy for Gynaecological Cancers: A Prospective Feasibility Study

Journal of Medical Radiation Sciences, EarlyView.
This prospective study investigated the feasibility of stabilised hyaluronic acid gel as a rectal spacer in gynaecological cancer brachytherapy. In twelve patients, the spacer was successfully inserted into the rectovaginal space without serious adverse events, had high visibility on MRI, increased the target‐to‐rectum distance compared with no spacer ...
Carminia Lapuz, Sylvia Hanna, Eddie Lau, Adeline Lim, Mark Tacey, Daryl Lim Joon, Claire Dempsey, Jenny Sim, Michael Chao   +8 more
wiley   +1 more source