Results 261 to 270 of about 82,070 (285)

DNTTIP1 drives leukaemogenesis through MiDAC‐mediated epigenetic silencing of BMF

Clinical and Translational Medicine, Volume 16, Issue 2, February 2026.
DNTTIP1 cooperates with SP1 to recruit HDAC1/2, leading to BMF silencing and reduced competitive binding of BMF to BCL2.This suppresses autophagy and apoptosis, promoting leukaemic cell survival. Targeting the DNTTIP1‐HDAC1/2‐BMF axis reactivates BMF and induces anti‐leukaemic effects.
Ruolin Xiu, Yuzhu Ma, Yueying Gao, Yao Chen, Xinyu Li, Yue Wu, Meiling Sun, Qizhao Li, Yanhong Zhao, Shuqian Xu, Shengjin Fan, Yongsheng Li, Huitao Fan   +12 more
wiley   +1 more source

Proteomic Analysis of Regulated Dendritic Cell Endosomes Reveals Dynamic Adaptation to Antigen Uptake and Cross‐Presentation

European Journal of Immunology, Volume 56, Issue 2, February 2026.
Phagocytosis of yeast activates recruitment of proteases and trafficking factors from the secretory and endosomal pathways to the IRAP compartment and subsequently phagosomes, promoting cross‐presentation. In the absence of Sec22b, IRAP endosome and phagosome maturation to late endosomes is accelerated.
Alice Senni, Louise Grumbach, Sara Ceccacci, Mathieu Frechin, Nicolas Goudin, Ida Chiara Guerrera, Barbara Bertocci, Peter van Endert   +7 more
wiley   +1 more source

The Performance of Automatic Speaking Valves and Fixation Devices Enabling Hands‐Free Speech Following Total Laryngectomy—A Systematic Review

Head &Neck, Volume 48, Issue 2, Page 549-569, February 2026.
ABSTRACT Background The percentage of daily automatic speaking valve use (AU) in laryngectomized patients has remained at ~25% since their invention. To increase this percentage, understanding the performance of existent devices is essential. Therefore, we reviewed studies reporting AU, fixation device lifetime (FDL), compliance, and voice and speech ...
Max J. Dullaart, Sebastiaan R. de Vreugd, Maartje Leemans, Rob van Son, Arjan Malekzadeh, Maarten J. A. van Alphen, Lisette van der Molen, Michiel W. M. van den Brekel, Luc H. E. Karssemakers, Richard Dirven   +9 more
wiley   +1 more source

Circulating fatty acid binding protein 4 (FABP‐4) concentrations and mortality in individuals with colorectal cancer in the European Prospective Investigation into Cancer and Nutrition study

International Journal of Cancer, Volume 158, Issue 3, Page 546-559, 1 February 2026.
What's new? Higher pre‐diagnostic body mass index has been associated with higher risk of mortality in individuals with colorectal cancer; however, the mechanism remains unclear. This prospective analysis of incident colorectal cancer cases within the European Prospective Investigation into Cancer and Nutrition cohort study addressed potential collider
Thu Thi Pham, Katharina Nimptsch, Krasimira Aleksandrova, Mazda Jenab, Veronika Fedirko, Anja Olsen, Anne Tjønneland, Claire Cadeau, Gianluca Severi, Matthias B. Schulze, Renée Turzanski Fortner, Verena Katzke, Claudia Agnoli, Carlotta Sacerdote, Rosario Tumino, Simona Signoriello, Camino Trobajo‐Sanmartín, Jesús‐Humberto Gómez, María‐Dolores Chirlaque, Maria‐Jose Sánchez, Marta Crous‐Bou, Anne May, Alicia Heath, Dagfinn Aune, Elisabete Weiderpass, Tobias Pischon   +25 more
wiley   +1 more source

Genetic variants underlying precancerous conditions of hepatocellular carcinoma

International Journal of Cancer, Volume 158, Issue 3, Page 488-502, 1 February 2026.
Abstract Hepatocellular carcinoma (HCC) is the most common form of liver cancer, accounting for 80% of cases worldwide. While chronic hepatitis B and C infections remain primary risk factors, emerging evidence highlights the increasing contributions of metabolic dysfunction‐associated steatotic liver disease (MASLD) and alcohol‐associated liver disease
Jonathan Jaime G. Guerrero, Paolo C. Encarnacion, Mark Angelo S. del Rosario, Matthew Aldren S. Ora, Jiayan Zhou, Kin Israel Notarte, Wan‐Chun Li, Ching‐Wen Chang   +7 more
wiley   +1 more source

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MR-guided radiotherapy for prostate cancer: an inevitable transition?

Current Opinion in Urology
PURPOSE OF REVIEW The rising global incidence of prostate cancer has intensified both clinical and economic pressures to optimize radiotherapy (RT) delivery.
R. Stando, Grzegorz Chmielewski
semanticscholar   +2 more sources

Advancements in adaptive MR-guided radiotherapy for high-grade gliomas

Journal of Neuro-Oncology
Glioblastoma multiforme (GBM) is the most common primary malignancy of the central nervous system, with a poor prognosis despite multimodal treatment approaches. With the development and integration of Magnetic Resonance-guided Linear Accelerator (MR-Linac) technology into the treatment paradigm for high-grade gliomas, there is promising potential for ...
Alexander S. Marwaha, M. Shepard, S. Karlovits, John Herbst, Rodney E. Wegner   +4 more
semanticscholar   +3 more sources

Reliability of MRI radiomics features in MR-guided radiotherapy for prostate cancer: Repeatability, reproducibility, and within-subject agreement.

Medical Physics (Lancaster), 2021
PURPOSE The MR-guided radiotherapy (MRgRT) images on the integrated MRI and linear accelerator (MR-LINAC) might facilitate radiomics analysis for longitudinal treatment response assessment.
Cindy Xue, Jing Yuan, D. Poon, Yihang Zhou, Bin Yang, S. Yu, Yin Kin Cheung   +6 more
semanticscholar   +1 more source

An abdominal phantom with anthropomorphic organ motion and multimodal imaging contrast for MR-guided radiotherapy

Physics in Medicine and Biology, 2022
Purpose. Improvements in image-guided radiotherapy (IGRT) enable accurate and precise treatment of moving tumors in the abdomen while simultaneously sparing healthy tissue.
Artur Weidner, C. Stengl, Fabian Dinkel, S. Dorsch, C. Murillo, S. Seeber, Regula Gnirs, A. Runz, G. Echner, C. Karger, O. Jäkel   +10 more
semanticscholar   +1 more source

Bowel tracking for MR-guided radiotherapy: simultaneous optimization of small bowel imaging and tracking

Physics in Medicine and Biology
Objective. The small bowel is one of the most radiosensitive organs-at-risk during radiotherapy in the pelvis. This is further complicated due to anatomical and physiological motion.
Saskia L.C. Damen, A. V. van Lier, C. Zachiu, B. Raaymakers   +3 more
semanticscholar   +1 more source