Results 51 to 60 of about 732,665 (350)

Limiting and Degradation Processes of Magnetorheological Suspension Dampers [PDF]

, 2011
Tato práce se zabývá výzkumem degradace magnetoreologické (MR) kapaliny v průběhu dlouhodobého zatěžování v podmínkách, které odpovídají reálnému zatížení v lineárních MR zařízení, např. v tlumičích.
Roupec, Jakub
core  

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source

Evaluation of cluster formation and flow characteristics of magneto-rheological fluid in a branch pipe under the magnetic field for shutting down leakage

Nihon Kikai Gakkai ronbunshu, 2015
Flow dynamics of magneto-rheological (MR) fluid in a branch pipe as a simple model of a cracked pipe and a blood vessel with wounds is clarified by considering the effects of magnetic field intensity, inner diameter of a branch channel and wall ...
Makoto HARADA, Satoshi UEHARA, Hidemasa TAKANA, Hideya NISHIYAMA   +3 more
doaj   +1 more source

Low-field magnetic resonance imaging and multislice computed tomography for the detection of cervical syringomyelia in dogs [PDF]

, 2015
Background: Syringomyelia (SM) is defined as the presence of fluid- containing cavities within the parenchyma of the spinal cord. Sagittal magnetic resonance (MR) images have been described as the preferred technique for visualizing SMin dogs and humans.
Akiyama, Barone, Bland, Bou-Haider, Brodfelt, Capello, Carruthers, Costa, Couturier, Cross, Dennis, Dewey, Doyon, Drees, Driver, Driver, Feliu-Pascual, Fishbein, Freeman, Greitz, Hecht, Kirberger, Kitagawa, Klekamp, Kromhout, Landis, Lee, Levine, Loderstedt, Olby, Parker, R Core team, Rusbridge, Rusbridge, Rusbridge, Todor, Trigylidas   +36 more
core   +2 more sources

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Magnetorheological Fluid Filled Spring for Variable Stiffness and Damping: Current and Potential Performance

Frontiers in Materials, 2022
Magnetorheological (MR) fluid is a smart material utilized for semi-active damping devices thanks to its ability to become viscoelastic solid under a magnetic field and provide variable damping.
Stanislav Sikulskyi, Aryslan Malik, Daewon Kim   +2 more
doaj   +1 more source

Network Localization of Fatigue in Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Fatigue is among the most common symptoms and one of the main factors determining the quality of life in multiple sclerosis (MS). However, the neurobiological mechanisms underlying fatigue are not fully understood. Here we studied lesion locations and their connections in individuals with MS, aiming to identify brain networks ...
Olli Likitalo, Jaakko Kungshamn, Albert Bellmunt‐Gil, Silvia Tommasin, Abhineet Ojha, Matias Viitala, Juho Aaltonen, Jyrki Lötjönen, Juha Koikkalainen, Pauli Ylikotila, Patrizia Pantano, Merja Soilu‐Hänninen, Juho Joutsa   +12 more
wiley   +1 more source

Cerebrospinal fluid dynamics analysis using Time Spatial Labeling Inversion pulse (Time-SLIP) MR imaging in mice [PDF]

, 2023
Yusuke Tomita, Mitsuru Yagi, Fumiko Seki, Yuji Komaki, Morio Matsumoto, Masaya Nakamura   +5 more
openalex   +1 more source

Fluid and Neuroimaging Biomarkers in Microgliopathy Colony‐Stimulating Factor‐1 Receptor‐Related Disorders

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective This study aims to identify both fluid and neuroimaging biomarkers for CSF1R‐RD that can inform the optimal timing of treatment administration to maximize therapeutic benefit, while also providing sensitive quantitative measurements to monitor disease progression.
Tomasz Chmiela, Madison Reeves, Karen Jansen‐West, Judith Dunmore, Yuping Song, Audrey Strongosky, Sunil Gandhi, Gilana Pikover, Matt Blurton‐Jones, Robert C. Spitale, Erik H. Middlebrooks, Leonard Petrucelli, Mercedes Prudencio, Zbigniew K. Wszolek   +13 more
wiley   +1 more source

Reduced Muscular Carnosine in Proximal Myotonic Myopathy—A Pilot 1H‐MRS Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Myotonic dystrophy type 2 (proximal myotonic myopathy, PROMM) is a progressive multisystem disorder with muscular symptoms (proximal weakness, pain, myotonia) and systemic manifestations such as diabetes mellitus, cataracts, and cardiac arrhythmias.
Alexander Gussew, Maryam Kargaran, Maik Rothe, Andreas Deistung, Dietrich Stoevesandt, Walter A. Wohlgemuth, David Strube, Thomas Kendzierski, Anna Katharina Kölsch, Maurits Gerhard Abraham Heuschen, Markus Otto, Alexander Mensch   +11 more
wiley   +1 more source