Results 91 to 100 of about 40,132 (283)

Dosimetric evidence confirms computational model for magnetic field induced dose distortions of therapeutic proton beams

, 2017
Given the sensitivity of proton therapy to anatomical variations, this cancer treatment modality is expected to benefit greatly from integration with magnetic resonance (MR) imaging.
Bussmann, Michael, Gantz, Sebastian, Hoffmann, Aswin L, Lühr, Armin, Oborn, Bradley M, Schellhammer, Sonja M   +5 more
core   +1 more source

Development of a hybrid magnetic resonance/computed tomography-compatible phantom for magnetic resonance guided radiotherapy [PDF]

, 2020
The purpose of the present study was to develop a hybrid magnetic resonance/computed tomography (MR/CT)-compatible phantom and tissue-equivalent materials for each MR and CT image.
Baek, Hyeon-Man, Choe, Bo-Young, Kim, Min-Joo, Lee, Seu-Ran, Song, Kyu-Ho, Suh, Tae Suk   +5 more
core   +1 more source

Optimization of treatment planning workflow and tumor coverage during daily adaptive magnetic resonance image guided radiation therapy (MR-IGRT) of pancreatic cancer [PDF]

, 2018
Background To simplify the adaptive treatment planning workflow while achieving the optimal tumor-dose coverage in pancreatic cancer patients undergoing daily adaptive magnetic resonance image guided radiation therapy (MR-IGRT). Methods In daily adaptive
Cai, Bin, Green, Olga, Kim, Jin Sung, Mutic, Sasa, Olberg, Sven, Parikh, Parag J, Park, Justin C, Rodriguez, Vivian, Yang, Deshan, Zhang, Hao   +9 more
core   +2 more sources

Outcome of IWGT workshop on transcriptomic biomarkers for genotoxicity: Key considerations for bioinformatics

Environmental and Molecular Mutagenesis, EarlyView.
Abstract As a part of the International Workshop on Genotoxicity Testing (IWGT) in 2022, a workgroup was formed to evaluate the level of validation and regulatory acceptance of transcriptomic biomarkers that identify genotoxic substances. Several such biomarkers have been developed using various molecular techniques and computational approaches. Within
Matthew J. Meier, Florian Caiment, J. Christopher Corton, Roland Frötschl, Yurika Fujita, Danyel Jennen, Roman Mezencev, Carole Yauk   +7 more
wiley   +1 more source

Multimodal treatment for local recurrent malignant gliomas: resurgery and/or reirradiation followed by chemotherapy [PDF]

, 2019
The therapeutic management of recurrent malignant gliomas (MGs) is not determined. Therefore, the efficacy of a multimodal approach and a combination systemic therapy was investigated.
Bianco, Vincenzo, ELENA REBUZZI, Sara, Ferrara, Carla, Fusto, Carmela, GIRON BERRIOS, JULIO RODRIGO, Grassi, Massimiliano, Pecorari, Silvia, Prelaj, Arsela, Salvati, Maurizio, Stati, Valeria, Tomao, Silverio   +10 more
core   +1 more source

Consensus findings of an International Workshops on Genotoxicity Testing workshop on using transcriptomic biomarkers to predict genotoxicity

Environmental and Molecular Mutagenesis, EarlyView.
Abstract Gene expression biomarkers have the potential to identify genotoxic and non‐genotoxic carcinogens, providing opportunities for integrated testing and reducing animal use. In August 2022, an International Workshops on Genotoxicity Testing (IWGT) workshop was held to critically review current methods to identify genotoxicants using ...
Roland Froetschl, J. Christopher Corton, Henghong Li, Jiri Aubrecht, Scott S. Auerbach, Florian Caiment, Tatyana Y. Doktorova, Yurika Fujita, Danyel Jennen, Naoki Koyama, Matthew J. Meier, Roman Mezencev, Leslie Recio, Takayoshi Suzuki, Carole L. Yauk   +14 more
wiley   +1 more source

Deep learning in MR-guided radiotherapy

, 2021
Les pratiques modernes en radiothérapie améliorent considérablement le succès des traitements tout en épargnant autant que possible les tissus sains. Cela se fait en réduisant constamment les incertitudes en amont du traitement. La planification du traitement débute avec une acquisition 3D de la géométrie du patient.
openaire   +1 more source

Review of Transcriptomic Biomarkers That Predict In Vitro Genotoxicity in Human Cell Lines

Environmental and Molecular Mutagenesis, EarlyView.
ABSTRACT The current genotoxicity testing paradigm provides little mechanistic information, has poor specificity in predicting carcinogenicity in humans, and is not suited to assessing a large number of chemicals. Genomic technologies enable the characterization of genome‐wide transcriptional changes in response to chemical treatments that can inform ...
Heng‐Hong Li, Jiri Aubrecht, Tatyana Y. Doktorova, Danyel Jennen, J. Christopher Corton, Roland Froetschl, Roman Mezencev, Carole L. Yauk   +7 more
wiley   +1 more source

A simplified online adaptive workflow for long-course magnetic resonance-guided radiotherapy in esophageal cancer

Physics and Imaging in Radiation Oncology
Background and Purpose: Online adaptive magnetic resonance-guided radiotherapy (MRgRT) enables high-precision radiotherapy for esophageal cancer patients but is less feasible due to long on-table times in combination with long-course treatment.
Koen M. Kuijer, Roel Bouwmans, Lando S. Bosma, Stella Mook, Gert J. Meijer   +4 more
doaj   +1 more source

Efficacy of Multimodal Work‐Up of Head and Neck Squamous Cell Carcinoma Lymph Node Metastasis of Unknown Primary

Head &Neck, EarlyView.
ABSTRACT Background Head and neck squamous cell carcinoma (HNSCC) often presents with cervical lymph node metastasis, with 1%–4% of cases presenting as cancer of unknown primary (CUP). CUP poses diagnostic and therapeutic challenges and is linked to poorer survival outcomes.
Robin W. Jansen, Roland M. Martens, Obaida Abdulrahman, Laura Peferoen, C. René Leemans, Gerben J. C. Zwezerijnen, Jan‐Jaap Hendrickx, Pim de Graaf   +7 more
wiley   +1 more source