Results 241 to 250 of about 40,132 (283)

Fractionated Gamma Knife Radiation for Papillary Tumor of the Pineal Region: A Case Report and Literature Review

Clinical Case Reports, Volume 14, Issue 2, February 2026.
ABSTRACT Papillary tumor of the pineal region (PTPR) is a rare central nervous system neoplasm with an unpredictable clinical course. Gross total resection, the preferred treatment, is often unachievable due to the tumor's deep‐seated location, necessitating alternative therapies.
Arad Iranmehr, Negin Safari Dehnavi, Mohammad Shirani, Reza Samiee, Moein Targhi, Nooshin Banaee, Fatemeh Jafari   +6 more
wiley   +1 more source

Retrospective analysis of cutaneous immune‐related adverse events following checkpoint inhibitor therapy in melanoma patients reveals increased risk associated with the HLA‐B*51:01 allele

Cancer, Volume 132, Issue 3, 1 February 2026.
ABSTRACT Background While immune checkpoint inhibitors (ICIs) have shown significant efficacy, a common side effect is cutaneous immune‐related adverse events (irAEs). This study focuses on exploring the association between specific human leukocyte antigen (HLA) alleles and the development of cutaneous irAEs in melanoma patients undergoing ICI ...
Mckenzie DiLeo, Samantha Oglesby, Cheuk Hong Leung, Kristen E. Pauken, Sahira Farooq, Lauren E. Haydu, Shelby L. Kubicki, Rebeca Martinez, Macartney Welborn, Sana Zahiruddin, Jun Zou, Kai Cao, Anisha B. Patel   +12 more
wiley   +1 more source

A Giant Thoracic ALK‐Rearranged Mesenchymal Neoplasm in a Child

Cancer Reports, Volume 9, Issue 2, February 2026.
ABSTRACT Background Mesenchymal neoplasms characterized by ALK fusions mainly include inflammatory myofibroblastic tumors (IMTs) and epithelioid fibrous histiocytomas (EFHs). More recently, ALK‐rearranged mesenchymal tumors that are not IMTs or EFHs, characterized by S100 and CD34 coexpression, have been reported in a few small series and isolated case
Sheng Gao, Junhua Wu, Jun Fan, Xiaona Chang, Bo Huang, Danju Luo, Jun He, Heshui Shi, Xiaochuan Dong, Xiu Nie   +9 more
wiley   +1 more source

DNTTIP1 drives leukaemogenesis through MiDAC‐mediated epigenetic silencing of BMF

Clinical and Translational Medicine, Volume 16, Issue 2, February 2026.
DNTTIP1 cooperates with SP1 to recruit HDAC1/2, leading to BMF silencing and reduced competitive binding of BMF to BCL2.This suppresses autophagy and apoptosis, promoting leukaemic cell survival. Targeting the DNTTIP1‐HDAC1/2‐BMF axis reactivates BMF and induces anti‐leukaemic effects.
Ruolin Xiu, Yuzhu Ma, Yueying Gao, Yao Chen, Xinyu Li, Yue Wu, Meiling Sun, Qizhao Li, Yanhong Zhao, Shuqian Xu, Shengjin Fan, Yongsheng Li, Huitao Fan   +12 more
wiley   +1 more source

Proteomic Analysis of Regulated Dendritic Cell Endosomes Reveals Dynamic Adaptation to Antigen Uptake and Cross‐Presentation

European Journal of Immunology, Volume 56, Issue 2, February 2026.
Phagocytosis of yeast activates recruitment of proteases and trafficking factors from the secretory and endosomal pathways to the IRAP compartment and subsequently phagosomes, promoting cross‐presentation. In the absence of Sec22b, IRAP endosome and phagosome maturation to late endosomes is accelerated.
Alice Senni, Louise Grumbach, Sara Ceccacci, Mathieu Frechin, Nicolas Goudin, Ida Chiara Guerrera, Barbara Bertocci, Peter van Endert   +7 more
wiley   +1 more source

The Performance of Automatic Speaking Valves and Fixation Devices Enabling Hands‐Free Speech Following Total Laryngectomy—A Systematic Review

Head &Neck, Volume 48, Issue 2, Page 549-569, February 2026.
ABSTRACT Background The percentage of daily automatic speaking valve use (AU) in laryngectomized patients has remained at ~25% since their invention. To increase this percentage, understanding the performance of existent devices is essential. Therefore, we reviewed studies reporting AU, fixation device lifetime (FDL), compliance, and voice and speech ...
Max J. Dullaart, Sebastiaan R. de Vreugd, Maartje Leemans, Rob van Son, Arjan Malekzadeh, Maarten J. A. van Alphen, Lisette van der Molen, Michiel W. M. van den Brekel, Luc H. E. Karssemakers, Richard Dirven   +9 more
wiley   +1 more source

Circulating fatty acid binding protein 4 (FABP‐4) concentrations and mortality in individuals with colorectal cancer in the European Prospective Investigation into Cancer and Nutrition study

International Journal of Cancer, Volume 158, Issue 3, Page 546-559, 1 February 2026.
What's new? Higher pre‐diagnostic body mass index has been associated with higher risk of mortality in individuals with colorectal cancer; however, the mechanism remains unclear. This prospective analysis of incident colorectal cancer cases within the European Prospective Investigation into Cancer and Nutrition cohort study addressed potential collider
Thu Thi Pham, Katharina Nimptsch, Krasimira Aleksandrova, Mazda Jenab, Veronika Fedirko, Anja Olsen, Anne Tjønneland, Claire Cadeau, Gianluca Severi, Matthias B. Schulze, Renée Turzanski Fortner, Verena Katzke, Claudia Agnoli, Carlotta Sacerdote, Rosario Tumino, Simona Signoriello, Camino Trobajo‐Sanmartín, Jesús‐Humberto Gómez, María‐Dolores Chirlaque, Maria‐Jose Sánchez, Marta Crous‐Bou, Anne May, Alicia Heath, Dagfinn Aune, Elisabete Weiderpass, Tobias Pischon   +25 more
wiley   +1 more source

Genetic variants underlying precancerous conditions of hepatocellular carcinoma

International Journal of Cancer, Volume 158, Issue 3, Page 488-502, 1 February 2026.
Abstract Hepatocellular carcinoma (HCC) is the most common form of liver cancer, accounting for 80% of cases worldwide. While chronic hepatitis B and C infections remain primary risk factors, emerging evidence highlights the increasing contributions of metabolic dysfunction‐associated steatotic liver disease (MASLD) and alcohol‐associated liver disease
Jonathan Jaime G. Guerrero, Paolo C. Encarnacion, Mark Angelo S. del Rosario, Matthew Aldren S. Ora, Jiayan Zhou, Kin Israel Notarte, Wan‐Chun Li, Ching‐Wen Chang   +7 more
wiley   +1 more source

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1. MR-guided adaptive stereotactic radiotherapy: A new paradigm in radiotherapy

Physica Medica, 2017
Introduction In May 2016 we have implemented stereotactic MR-guided adaptive radiation therapy at the VU University Medical Center by using the MRIdian system (ViewRay, Inc.). Our approach consists of: (1) MR-guided tumor setup; (2) daily online plan adaptation to account for inter-fractional changes; (3) patient-specific QA; (4) gated treatment ...
M.A. Palacios, O. Bohoudi, S. Senan, B. Slotman, A. Bruynzeel, F.J. Lagerwaard   +5 more
openaire   +1 more source

Soft-tissue prostate intrafraction motion tracking in 3D cine-MR for MR-guided radiotherapy

Physics in Medicine & Biology, 2019
To develop a method to automatically determine intrafraction motion of the prostate based on soft tissue contrast on 3D cine-magnetic resonance (MR) images with high spatial and temporal resolution. Twenty-nine patients who underwent prostate stereotactic body radiotherapy (SBRT), with four implanted cylindrical gold fiducial markers (FMs), had cine-MR
D M de Muinck Keizer, L G W Kerkmeijer, M Maspero, A Andreychenko, J R N van der Voort van Zyp, C A T van den Berg, B W Raaymakers, J J W Lagendijk, J C J de Boer   +8 more
openaire   +4 more sources