Results 91 to 100 of about 278,920 (305)

Photothermal Amplification via Nanorobotic Swarming Dynamics

Advanced Science, EarlyView.
This study explores a novel approach to enhance photothermal therapy using magnetically regulated microswarms. It details the development of magnetic nanoparticles organized into dynamic structures that improve heat retention and conversion efficiency.
Qinglong Wang, Lin Su, Zhengxin Yang, Yihang Jiang, Haojin Yang, Qianqian Wang, Li Zhang, Ben Wang, Jiajia Wang   +8 more
wiley   +1 more source

Computer Vision Enables Monitoring and Kinetic Analysis of Structurally Diverse Carbon Monoxide Surrogates

Angewandte Chemie, EarlyView.
A non‐contact computer vision method enables monitoring and quantitative comparison of vessel‐specific CO release kinetics from structurally diverse surrogates in two‐chamber COware reactors, revealing that surrogate reactivity scores correlate with carbonylation reaction outcomes.
Kristin Donnachie, Ciaran Griffin, Morven L. Gray, Timothy J. D. McCabe, Marc Reid   +4 more
wiley   +2 more sources

Three-Dimensional Mesoscopic DEM Modeling and Compressive Behavior of Macroporous Recycled Concrete

Buildings
The mesoscopic-scale discrete element method (DEM) modeling approach demonstrated high compatibility with macroporous recycled concrete (MRC). However, existing DEM models failed to adequately balance modeling accuracy and computational efficiency for ...
Yupeng Xu, Fei Geng, Haoxiang Luan, Jun Chen, Hangli Yang, Peiwei Gao   +5 more
doaj   +1 more source

Adipocyte Myoglobin Is a Determinant of Energy Expenditure and a Potential Target to Limit Obesity

Advanced Science, EarlyView.
Myoglobin, known as a muscle oxygen‐carrying protein, is shown to play a key role in fat cells that burn energy. Loss of myoglobin reduces the body's ability to generate heat and increases obesity risk, while restoring it improves metabolism. The study identifies myoglobin as a regulator of fat burning and a potential target to enhance energy ...
Christian Strehlau, Helen Broghammer, Claudia Gebhardt, Anne Hoffmann, Tobias Hagemann, Şeyma Midilli, Rachel S. Zimmer, Kristin Schubert, Vasiliki Karagiannakou, Anastasia Georgiadi, Mario Ost, Martin Krüger, Lisa Roth, Kerstin Krause, Nora Klöting, Maria Keller, Martin Wabitsch, Rima Nuwayhid, Roland H. Stimson, Michael Stumvoll, Matthias Blüher, Juliane Weiner, John T. Heiker   +22 more
wiley   +1 more source

Multicomponent Stapling of Glucagon‐Like Peptide‐1 Enables Receptor‐Guided PROTAC Delivery

Angewandte Chemie, EarlyView.
We report a stapled glucagon‐like peptide‐1 (GLP‐1) analogue created via multicomponent tryptophan‐mediated Petasis reaction (TMPR). This strategy yields a stabilised peptide with superior helicity and improved potency. Conjugation to a bromodomain‐containing protein 4 (BRD4) degrader creates the first GLP‐1‐guided targeted protein degrader (PROTAC ...
Jan L. Venne, Sona Krajcovicova, Graeme Davies, Hannah Bolt, Jefferson Revell, David R. Spring   +5 more
wiley   +2 more sources

Determination of Organic Contaminants in Sediments Using Trace Analysis and Biological Screening Assay

, 2004
Gwangyang Bay located in the southern coast of Korea is a semi-enclosed embayment including a big steel mill plant and petroleum refinery plant complex around the bay.
홍상희, 임운혁, 전중균, 심원준, 오재룡   +4 more
core  

ORBIT‐AMD: Ordinal Risk, Bilateral Imaging, and Trajectory Learning for Age‐Related Macular Degeneration in Multi‐Cohorts

Advanced Science, EarlyView.
Eligibility flow and real‐world AMD burden in the UKB retinal imaging cohort and TMUEH external‐validation cohort. Overview of the ORBIT‐AMD architecture, integrating retinal representation pretraining, bilateral eye‐graph modeling and concept bottleneck learning to support ordered risk, bilateral context, interpretable lesion concepts, longitudinal ...
Xuehao Cui, Dejia Wen, Patrick Yu‐Wai‐Man, Xiaorong Li   +3 more
wiley   +1 more source

Adverse karyotype amplifies risk in secondary acute myeloid leukemia (AML) and AML with myelodysplasia-related changes

Hematology
Background Secondary acute myeloid leukemia (sAML) and AML with myelodysplasia-related changes (AML-MRC) are associated with poor prognosis, but the impact relative to de novo AML remains controversial.
Toshihiro Matsukawa, Shota Yoshida, Masahiro Onozawa, Fumiaki Fujii, Jun Nagai, Tomoki Takahashi, Shuichi Ota, Junichi Hashiguchi, Akio Mori, Takuto Miyagishima, Makoto Ibata, Yasutaka Kakinoki, Tatsuo Oyake, Satoshi Yamamoto, Toshiaki Hayashi, Kentaro Wakasa, Tomoyuki Saga, Tetsuya Igarashi, Satoshi Iyama, Yutaka Tsutsumi, Katsuya Fujimoto, Masaaki Adachi, Masahiro Yoshida, Daigo Hashimoto, Takanori Teshima   +24 more
doaj   +1 more source

Comparison of the effect of rhodium citrate-associated iron oxide nanoparticles on metastatic and non-metastatic breast cancer cells

Cancer Nanotechnology, 2019
Background Nanocarriers have the potential to improve the therapeutic index of currently available drugs by increasing drug efficacy, lowering drug toxicity and achieving steady-state therapeutic levels of drugs over an extended period.
Natalia Lemos Chaves, Danilo Aquino Amorim, Cláudio Afonso Pinho Lopes, Irina Estrela-Lopis, Julia Böttner, Aparecido Ribeiro de Souza, Sônia Nair Báo   +6 more
doaj   +1 more source

Study protocol: Delayed intervention randomised controlled trial within the Medical Research Council (MRC) Framework to assess the effectiveness of a new palliative care service

, 2006
Background: Palliative care has been proposed to help meet the needs of patients who suffer progressive non-cancer conditions but there have been few evaluations of service development initiatives.
Polly Edmonds, Vivat, B, Irene J Higginson, Edmonds, P, Hart, S, Bella Vivat, Saleem, T, Tariq Saleem, Salem, T, Higginson, IJ, Silber, E, Higginson, I; id_orcid, Rachel Burman, Burman, R, Eli Silber, Sam Hart   +15 more
core   +1 more source