Results 101 to 110 of about 278,920 (305)
, 2020 Fixed bugs in draw_one_set_of_ancestries resulting from incorrect lengths and an undefined variable (issue #92) (#93, @jstockwin) Fixed incorrect quantiles (issue #88) (#89, @jstockwin)2.2-
Thibaut Jombart +13 more
core +1 more source
Large‐Scale Machine Learning to Screen for Small‐Molecule Senolytics
Advanced Intelligent Discovery, EarlyView.A consistent workflow underpins all experiments in this study. A dedicated model‐selection dataset first identifies optimal hyperparameters for each algorithm. Models are then trained and rigorously evaluated on independent sets of molecules using the senolytic ratio SR. Comprehensive hyperparameter exploration across SMILES representations, task types,
Alexis Dougha +2 more
wiley +1 more source
MRC - TROPMED bibliography on mosquito borne diseases in Asia, 1984
, 1986 Companion volume to: MRC-TROPMED bibliographical record on the 1983 current literature : mosquito borne diseases in ...
TROPMED National Centre of Thailand
core
American Journal of Hematology, EarlyView.ABSTRACT The clinical significance of PNH Type II white blood cells (WBCs) remains unclear. We assessed the relative percentage (rel%) of Type II neutrophils in 355 patients with a PNH clone ≥ 1% on neutrophils enrolled by 33 flow cytometry laboratories in the 5‐year French nation‐wide multicenter prospective observational study.
Orianne Wagner‐Ballon +41 more
wiley +1 more source
Process Evaluation of Complex Interventions Guidance: UK Medical Research Council (MRC) Guidance
, 2014 Updated MRC guidance for evaluation of complex interventions published in 2008 (Craig et al.2008) highlighted the value of process evaluation within trials of complex interventions in order to understand implementation, the mechanisms through which ...
Wight, Danny +10 more
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Commentary: MRC Patulin trial [PDF]
International Journal of Epidemiology, 2004 The MRC Patulin trial1 was undertaken in 1943–1944 to investigate a proposed remedy for the common cold. Only a few clinical trials took place before the second world war and they often had serious defects of planning or execution. The Patulin trial, it is claimed, was the first to meet the rigorous requirements for a scientifically acceptable trial ...
openaire +2 more sources
RIPK3 dampens mitochondrial bioenergetics and lipid droplet dynamics in metabolic liver disease
Hepatology, EarlyView., 2022 RIPK3 dampens mitochondrial bioenergetics and lipid droplet dynamics in metabolic liver disease. Abstract Background and Aims Receptor‐interacting protein kinase 3 (RIPK3) mediates NAFLD progression, but its metabolic function is unclear. Here, we aimed to investigate the role of RIPK3 in modulating mitochondria function, coupled with lipid droplet (LD)
Marta B. Afonso +16 more
wiley +1 more source
Gemma docked outside MRC at MRC opening 1992
, 1992 View of the Gemma docked outside the MRC, with MRC visible in background at the time of the MRC ...
core
c‐Rel–dependent Chk2 signaling regulates the DNA damage response limiting hepatocarcinogenesis
Hepatology, EarlyView., 2022 In response to genotoxic injury, c‐Rel upregulates ATM‐Chk2‐p53 pathway DNA damage proteins to limiting hepatocarcinogenesis. Abstract Background and Aims Hepatocellular carcinoma (HCC) is a leading cause of cancer‐related death. The NF‐κB transcription factor family subunit c‐Rel is typically protumorigenic; however, it has recently been reported as a
Jack Leslie +17 more
wiley +1 more source