Results 131 to 140 of about 96,614 (276)

Investigating the Cytoskeleton of DRGs Using Cryo‐Electron Microscopy and Deep Learning

Cytoskeleton, EarlyView.
ABSTRACT We describe a method for determining the ultrastructural organization of axons and varicosities of cultured dorsal root ganglion (DRG) neurons using cryogenic electron microscopy (cryo‐EM). Cryo‐EM reveals the dimensions, proximity, and overall organization of biological specimens in a near‐native state, avoiding artifacts of fixation and ...
M. Neal Waxham, Mihir Relan, Matthew T. Swulius, Andrea K. H. Stavoe   +3 more
wiley   +1 more source

Effect of SK-216 on fibroblast to myofibroblast differentiation induced by TGF-β1 in MRC-5 cells.

, 2016
After pre-incubation in serum free medium for 24 hours, MRC-5 cells were pretreated in the presence or absence of SK-216 (50, 150 μM) for 1 hour followed by stimulation with TGF-β1 (5 ng/ml).
Noboru Hattori (849176), Keitaro Omori (849175), Taku Nakashima (849180), Hiroshi Iwamoto (849181), Nobuoki Kohno (224941), Hironobu Hamada (844049), Yusuke Takayama (849178), Kazunori Fujitaka (849182), Takeshi Masuda (849179), Tadashi Senoo (849177)   +9 more
core   +1 more source

Prediction of Acute Liver Injury Trajectory in Patients Following Acetaminophen Overdose: A Multibiomarker Machine Learning Proof‐of‐Concept Study

Clinical Pharmacology &Therapeutics, EarlyView.
Clinical translation of novel therapies can be hindered by heterogeneity‐driven sample size inflation in late‐stage trials. In acetaminophen‐induced liver injury (APAP DILI), many patients recover spontaneously, diluting investigational drug efficacy signals.
Chris Humphries, Alastair M. Kilpatrick, Kathleen M. Scullion, Rhona Aird, Lorraine Bruce, Maria Elena Candela, Tak Yung Man, Stuart J. Forbes, James W. Dear   +8 more
wiley   +1 more source

MRC/BHF Heart Protection Study of cholesterol lowering with simvastatin in 20 536 high-risk individuals: a randomised placebocontrolled trial

, 2002
Background: Throughout the usual LDL cholesterol range in Western populations, lower blood concentrations are associated with lower cardiovascular disease risk.
Heart Protection Study Collaborative Group
core   +1 more source

Scalable Reverse Converters for the Moduli Set {2n+1−1,2n−1,2n−1−1}$$ \left\{{2}^{n+1}-1,{2}^n-1,{2}^{n-1}-1\right\} $$ (n$$ n $$ Even)

International Journal of Circuit Theory and Applications, EarlyView.
This work explores the conversion from residues to binary representation in RNS using the Chinese remainder theorem (CRT) or mixed radix conversion (MRC) algorithms. The proposed approach relocates CRT multiplicative inverses to the arithmetic stage without extra cost, improving scalability while achieving speedups over state‐of‐the‐art MRC ...
Gabriel B. M. Fernandes, Hector Pettenghi, Lucas R. Kieslich   +2 more
wiley   +1 more source

MRC/BHF Heart Protection Study of antioxidant vitamin supplementation in 20 536 high-risk individuals: a randomised placebo-controlled trial

, 2002
Background It has been suggested that increased intake of various antioxidant vitamins reduces the incidence rates of vascular disease, cancer, and other adverse outcomes.
Heart Protection Study Collaborative Group, Sleight, P, Collaborati, HPS, Parish, Sarah, Collins, R, Armitage, J, Peto, Richard, Parish, S, Peto, R   +8 more
core   +1 more source

Loss of POGLUT2/3‐mediated O‐glucosylation produces lung and aortic phenotypes reminiscent of fibrillin1 mutants

Developmental Dynamics, EarlyView.
Abstract Background Fibrillins provide a scaffold for elastic fiber formation, which enables lung recoil and aortic compliance. Abnormal fibrillin microfibrils, as in Marfan syndrome, lead to enlarged alveoli, vascular stiffening, and aneurysms. Our earlier studies suggested that fibrillin function depends on O‐glucosylation of its epidermal growth ...
Sanjiv Neupane, Angelina Almiroudis, Kaitlyn E. Donnelly, Robert S. Haltiwanger, Bernadette C. Holdener   +4 more
wiley   +1 more source

Angiotensin—(1–7) and miRNA-149-3p modulates MRC-5 cell motility and migration.

, 2016
A) MRC-5 cells were grown in 6-well plates under different culture conditions. Under confluency, cellular migration was verified by wound healing assay and the recovery area of the injury was measured in each condition analyzed and plotted in graphs.
Kelvin Furtado Lima (3106485), Letícia Rocha Gonçalves (3106482), Brenda de Oliveira da Silva (3106488), Marina Bonfogo da Silveira (3106494), Karen C. M. Moraes (3106491)   +4 more
core   +1 more source

Psilocybin as a Transdiagnostic Treatment for Eating Disorders and Comorbid Psychopathology: Implications for Clinical Nosology and Research Directions

International Journal of Eating Disorders, EarlyView.
ABSTRACT Objective Eating disorders (EDs) are characterized by high rates of psychiatric comorbidity and suboptimal treatment outcomes. There remain critical gaps in research, including the exploration of effective transdiagnostic interventions. This forum article examines the potential of psilocybin treatment (PT) as a transdiagnostic intervention for
Elena Koning, Jérémie Richard, Aaron Keshen   +2 more
wiley   +1 more source

Outage analysis of ZFB-MRT/MRC underlay two-way relay systems

, 2015
—We analyse the end-to-end (E2E) outage proba-bilities (OPs) of zero-forcing beamforming and maximal-ratio-transmission/combining (ZFB-MRT/MRC) for an underlay net-work, which consists of a single-antenna fixed-gain amplify-and-forward (AF) two-way relay
Chintha Tellambura, Yun Cao
core