Results 111 to 120 of about 93,971 (246)
This report was written by a group of independent experts set up in collaboration between BBSRC and MRC and asked to provide recommendations on strategy for BBSRC and MRC, and for UKRI more generally, to meet challenges and develop opportunities for large-scale computing across bioscience research.
openaire +2 more sources
British Journal of Clinical Pharmacology, EarlyView.Abstract Irinotecan, a topoisomerase I inhibitor, is available as both non‐pegylated and pegylated formulations. The non‐pegylated formulation is licensed for use in advanced colorectal cancer either in combination with other agents or as monotherapy.
Dharmisha Chauhan +24 more
wiley +1 more source
Pharmacogenomics of dolutegravir: A scoping review of evidence, gaps and clinical implications
British Journal of Clinical Pharmacology, EarlyView.Dolutegravir underpins modern first‐ and second‐line HIV treatment regimens; however, interindividual variability in its disposition and tolerability presents challenges for optimal use. This scoping review mapped current evidence on the pharmacogenomics of dolutegravir, focusing on pharmacokinetics and pharmacodynamics, and methodological limitations ...
Ronald Kiguba +2 more
wiley +1 more source
The Canadian Journal of Chemical Engineering, EarlyView.Abstract This study investigates the effect of moisture on CO2 adsorption in South African coals using both experimental and machine learning approaches. Three coal samples (SL, TN, and EM) with varying ranks (RoVmr: 3.49%, 1.26%, and 0.64%, respectively) were collected from different regions of South Africa.
Kasturie Premlall +3 more
wiley +1 more source
Hydrogen donor‐assisted visbreaking of Canadian oil sands bitumen
The Canadian Journal of Chemical Engineering, EarlyView.Abstract High‐viscosity Canadian oil sands bitumen requires processing for efficient transportation and refining. Partial upgrading technologies, primarily based on thermal processing, can effectively reduce, or even eliminate, the use of costly diluent, increase bitumen quality and market value, potentially decrease greenhouse gas (GHG) emissions, and
Yi Zhang, Mohamed Ali, Jinwen Chen
wiley +1 more source
Cytoskeleton, EarlyView.ABSTRACT Cooperativity between cytoskeletal proteins is crucial for spatiotemporal coordination in biological processes, like oogenesis. In mammalian and Drosophila oogenesis, proper assembly and function of actin networks require coordination between actin assembly factors Spire and formins, as well as actin‐associated proteins like myosins and Rab ...
Joseph Y. Ong +7 more
wiley +1 more source
Investigating the Cytoskeleton of DRGs Using Cryo‐Electron Microscopy and Deep Learning
Cytoskeleton, EarlyView.ABSTRACT We describe a method for determining the ultrastructural organization of axons and varicosities of cultured dorsal root ganglion (DRG) neurons using cryogenic electron microscopy (cryo‐EM). Cryo‐EM reveals the dimensions, proximity, and overall organization of biological specimens in a near‐native state, avoiding artifacts of fixation and ...
M. Neal Waxham +3 more
wiley +1 more source
Assembly and Maintenance of Myofibrils in the Heart
Cytoskeleton, EarlyView.ABSTRACT The assembly of actin and myosin to the paracrystalline arrangement of myofibrils in striated muscle, that is, heart and skeletal, has puzzled many a cell biologist. Different models, based on cultured cardiomyocytes, were proposed for the last 30 years to explain the sequence of events.
Elisabeth Ehler
wiley +1 more source