Results 101 to 110 of about 12,824,675 (274)

Large-Scale Computing Opportunities and Challenges. A Report from a Supercomputing Task Force for BBSRC and MRC

This report was written by a group of independent experts set up in collaboration between BBSRC and MRC and asked to provide recommendations on strategy for BBSRC and MRC, and for UKRI more generally, to meet challenges and develop opportunities for ...
Mulholland, Adrian J
core   +1 more source

Clinical Course and Short-Term Outcome of Mild Guillain-Barré Syndrome: A Retrospective Observational Study from Western India

Perspectives In Medical Research
Background: Guillain-Barré Syndrome (GBS) has a variable clinical course. Limited data are available on therapeutic decisions in patients with mild disease severity.
Pranav B Joshi, Shalin D Shah, Mayank A Patel, Kailash Mirche, Swati Trivedi, Devanshi S Shah   +5 more
doaj   +1 more source

TNAP and PHOSPHO1 Function Synergistically to Afford Critical Control Over the Mineralization of the Postnatal Murine Skeleton

Advanced Science, EarlyView.
Biomineralization underpins skeletal development, yet its molecular control remains incompletely understood. Using a novel murine knockout model, this study reveals the essential and complementary roles of PHOSPHO1 and TNAP in postnatal skeletal development.
Lucie E. Bourne, Aikta Sharma, Scott Dillon, Jacob Keen, Soher N. Jayash, Natalie Crump, Lucinda A.E. Evans, Maya Karmali, Worachet Promruk, Claire E. Clarkin, Sonoko Narisawa, Louise Stephen, Brian L. Foster, José Luis Millán, Colin Farquharson, Katherine A. Staines   +15 more
wiley   +1 more source

MRC dyspnoea grade distribution by stage of airflow limitation (first MRC grade from study start).

, 2014
Abbreviations: COPD, chronic obstructive pulmonary disease; MRC, Medical Research Council. MRC scoring 1–5 equals to mMRC grades 0–4 with MRC 1 equals to mMRC 0.
Maggie Tabberer (508226), Hana Müllerová (508225), Chao Lu (4374), Hao Li (31608)   +3 more
core   +1 more source

Neuroanatomical correlates of prion disease progression - a 3T longitudinal voxel-based morphometry study

NeuroImage: Clinical, 2017
Purpose: MRI has become an essential tool for prion disease diagnosis. However there exist only a few serial MRI studies of prion patients, and these mostly used whole brain summary measures or region of interest based approaches.
Enrico De Vita, Gerard R Ridgway, Mark J White, Marie-Claire Porter, Diana Caine, Peter Rudge, John Collinge, Tarek A Yousry, Hans Rolf Jager, Simon Mead, John S Thornton, Harpreet Hyare   +11 more
doaj   +1 more source

Temporal Trajectories of the Tau Aggregate Interactome Reveal Stage‐Specific Vulnerabilities in Alzheimer's Disease

Advanced Science, EarlyView.
Tau populations with different aggregation states associate with distinct sets of proteins in the Alzheimer's disease brain. Proteomic discovery combined with single‐molecule analysis in neurons reveals dynamic associations involving proteostasis, metabolism and RNA biology.
Dorothea Böken, Paula Beltran Lobo, Yunzhao Wu, Lyla A. Rowe, Emre Fertan, Cara L. Croft, Maria Jimenez‐Sanchez, Dezerae Cox, David Klenerman   +8 more
wiley   +1 more source

Downsizing Electrophilic MAX‐Derived Helical Zipper Peptides to Covalently Bind and Degrade Oncogenic MYC

Angewandte Chemie, EarlyView.
Oncogenic MYC is a transcription factor that is difficult to inhibit. However, precise positioning of an acrylamide electrophile in MAX to covalently bond to the unique Cys438 in MYC, enabled shortening and optimizing of MAX‐derived, helix‐constrained peptides with high‐affinity and selectivity.
Aline Dantas de Araujo, Lei Luo, Mahan Azad, Miao Yu, Jody M. Mason, Junxian Lim, Timothy A. Hill, David P. Fairlie   +7 more
wiley   +2 more sources

Association of tissue oxygen saturation levels with skeletal muscle injury in the critically ill

Scientific Reports
This study aimed to investigate the association between the level of tissue oxygen saturation (StO2) and quadriceps/skeletal muscle dysfunction, measured using the Medical Research Council (MRC) scale and ultrasonography, in critically ill patients ...
Ryuji Sugiya, Shinichi Arizono, Yuji Higashimoto, Yuta Kimoto, Masashi Shiraishi, Hiroki Mizusawa, Yuichi Tawara, Hironori Shigeoka, Jan Bakker, Koichiro Shinozaki   +9 more
doaj   +1 more source

The Feasibility of a Music Therapy Respiratory Telehealth Protocol on Long COVID Respiratory Symptoms

COVID
Objective: This study aims to investigate the feasibility of an online music therapy protocol for individuals previously diagnosed with COVID-19, focusing on their perceptions of their respiratory symptoms and the intervention’s impact on psychosocial ...
Jingwen Zhang, Joanne V. Loewy, Lisa Spielman, Zijian Chen, Jonathan M. Raskin   +4 more
doaj   +1 more source

Optimal Nodes Selectiveness from WSN to Fit Field Scale Albedo Observation and Validation in Long Time Series in the Foci Experiment Areas, Heihe

Remote Sensing, 2015
To evaluate and improve the quality of land surface albedo products, validation with ground measurements of albedo is crucial over the spatially and temporally heterogeneous land surface. One of the essential steps for satellite albedo product validation
Xiaodan Wu, Qing Xiao, Jianguang Wen, Qiang Liu, Dongqin You, Baocheng Dou, Yong Tang, Xiaowen Li   +7 more
doaj   +1 more source