Results 101 to 110 of about 96,614 (276)

A Catalytic Osmium Redox Couple Collapses Cancer Redox Balance

Advanced Science, EarlyView.
A stable Os(III)/Os(IV) redox couple is developed to disrupt the tumor cell redox balance by concurrently catalyzing ROS generation and GSH depletion. Osmium‐treated cells exhibit multiple cell death pathways, including apoptosis, ferroptosis, and immunogenic cell death.
Wan‐Qiong Huang, Tao Huang, Yiming Hao, Gui‐Feng Huang, Yi‐Lang Yan, Xin Fang, Ying Chen, Xiao‐Long Wei, Wai‐Lun Man, Wen‐Xiu Ni   +9 more
wiley   +1 more source

Computer Vision Enables Monitoring and Kinetic Analysis of Structurally Diverse Carbon Monoxide Surrogates

Angewandte Chemie, EarlyView.
A non‐contact computer vision method enables monitoring and quantitative comparison of vessel‐specific CO release kinetics from structurally diverse surrogates in two‐chamber COware reactors, revealing that surrogate reactivity scores correlate with carbonylation reaction outcomes.
Kristin Donnachie, Ciaran Griffin, Morven L. Gray, Timothy J. D. McCabe, Marc Reid   +4 more
wiley   +2 more sources

Can long-term thiamine treatment improve the clinical outcomes of myotonic dystrophy type 1?

Neural Regeneration Research, 2016
Myotonic dystrophy type 1, also known as Steinert′s disease, is an autosomal dominant disorder with multisystemic clinical features affecting the skeletal and cardiac muscles, the eyes, and the endocrine system.
Antonio Costantini, Erika Trevi, Maria Immacolata Pala, Roberto Fancellu   +3 more
doaj   +1 more source

Prognosis in traumatic brain injury [PDF]

Introduction: The general purpose of this thesis was to study prognosis in traumatic brain injury (TBI) patients, with the aim of providing useful and practical information in clinical practice and clinical research.
Perel, Pablo Andraes
core   +1 more source

Fine-scale modelling finds that breeding site fragmentation can reduce mosquito population persistence [PDF]

, 2019
Fine-scale geographic variation in the transmission intensity of mosquito-borne diseases is primarily caused by variation in the density of female adult mosquitoes.
Ghani, Azra C, Ferguson, Neil M, McCormack, Clare P   +2 more
core   +1 more source

Photothermal Amplification via Nanorobotic Swarming Dynamics

Advanced Science, EarlyView.
This study explores a novel approach to enhance photothermal therapy using magnetically regulated microswarms. It details the development of magnetic nanoparticles organized into dynamic structures that improve heat retention and conversion efficiency.
Qinglong Wang, Lin Su, Zhengxin Yang, Yihang Jiang, Haojin Yang, Qianqian Wang, Li Zhang, Ben Wang, Jiajia Wang   +8 more
wiley   +1 more source

Adipocyte Myoglobin Is a Determinant of Energy Expenditure and a Potential Target to Limit Obesity

Advanced Science, EarlyView.
Myoglobin, known as a muscle oxygen‐carrying protein, is shown to play a key role in fat cells that burn energy. Loss of myoglobin reduces the body's ability to generate heat and increases obesity risk, while restoring it improves metabolism. The study identifies myoglobin as a regulator of fat burning and a potential target to enhance energy ...
Christian Strehlau, Helen Broghammer, Claudia Gebhardt, Anne Hoffmann, Tobias Hagemann, Şeyma Midilli, Rachel S. Zimmer, Kristin Schubert, Vasiliki Karagiannakou, Anastasia Georgiadi, Mario Ost, Martin Krüger, Lisa Roth, Kerstin Krause, Nora Klöting, Maria Keller, Martin Wabitsch, Rima Nuwayhid, Roland H. Stimson, Michael Stumvoll, Matthias Blüher, Juliane Weiner, John T. Heiker   +22 more
wiley   +1 more source

Development of an activity of daily living scale for patients with COPD: the Activity of Daily Living Dyspnoea scale. [PDF]

, 2009
BACKGROUND AND OBJECTIVE: Patients with COPD often experience restriction in their activities of daily living (ADL) due to dyspnoea. This type of restriction is unique to patients with COPD and cannot be adequately evaluated by the generic ADL scales ...
Senjyu, Hideaki, Yoza, Yoshiyasu, Taniguchi, Hiroyuki, Ariyoshi, Koya, Honda, Sumihisa   +4 more
core   +1 more source

ORBIT‐AMD: Ordinal Risk, Bilateral Imaging, and Trajectory Learning for Age‐Related Macular Degeneration in Multi‐Cohorts

Advanced Science, EarlyView.
Eligibility flow and real‐world AMD burden in the UKB retinal imaging cohort and TMUEH external‐validation cohort. Overview of the ORBIT‐AMD architecture, integrating retinal representation pretraining, bilateral eye‐graph modeling and concept bottleneck learning to support ordered risk, bilateral context, interpretable lesion concepts, longitudinal ...
Xuehao Cui, Dejia Wen, Patrick Yu‐Wai‐Man, Xiaorong Li   +3 more
wiley   +1 more source

Large‐Scale Machine Learning to Screen for Small‐Molecule Senolytics

Advanced Intelligent Discovery, EarlyView.
A consistent workflow underpins all experiments in this study. A dedicated model‐selection dataset first identifies optimal hyperparameters for each algorithm. Models are then trained and rigorously evaluated on independent sets of molecules using the senolytic ratio SR. Comprehensive hyperparameter exploration across SMILES representations, task types,
Alexis Dougha, Jesus Gil, Pedro J. Ballester   +2 more
wiley   +1 more source