Results 51 to 60 of about 12,824,675 (274)

Anomalous scales of Tillandsia usneoides (L.) L. (Bromeliaceae) exposed in the Metropolitan Region of Campinas, SP, Brazil as air pollution markers

Hoehnea
Tillandsia usneoides is an epiphytic bromeliad that has been used as a universal bioindicator. The species accumulates metals and presents foliar scale variations when exposed to air pollutants.
Patrícia Giampaoli, Natalie do Valle Capelli, Armando Reis Tavares, Francine Faia Fernandes, Marisa Domingos, Edenise Segala Alves   +5 more
doaj   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Analysis of MRC-funded non-academic impacts submitted to REF2021

, 2023
This report provides a selection of research impacts submitted by UK higher education institutions (HEIs) to the 2021 REF assessment that had a connection to the Medical Research Council (MRC) investments.
Samarasinghe, S., Pitrolino, K.
core  

A pilot clinical study on the Traditional Korean Medicine treatment of Amyotrophic lateral sclerosis

Journal of Pharmacopuncture, 2009
Objectives : This study was to investigate the effect of Oriental medical treatment on ALS. Methods : We investigated 12 ALS patients which were admitted to Gwang-Ju O.M. hospital from Oct. 14, 2008 to Nov. 14, 2008.
Kim Sung-chul, Na Won-min, Lim Na-ra, Lee Do-sang, Jang Eun-ha, Song Bong-keun   +5 more
doaj   +1 more source

Quality of life and psychological disorders in Egyptian patients with chronic lung diseases: Clinico-physiological correlation

Egyptian Journal of Chest Disease and Tuberculosis, 2014
Objectives: Chronic lung diseases lead to impairment of daily activities, work and quality of life. The aim of this work was to assess the quality of life, depression and anxiety in Egyptian patients with chronic lung diseases. Patients and methods: This
Tamer S. Morsi, Soha Ghobashy, Gihan Younis   +2 more
doaj   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Integrated Field Surveying and Land Surface Quantitative Analysis to Assess Landslide Proneness in the Conero Promontory Rocky Coast (Italy)

Applied Sciences, 2020
Rock slopes involved in extensive landslide processes are often characterized by complex morphodynamics acting at different scales of space and time, responsible for different evolutionary scenarios.
Francesco Troiani, Salvatore Martino, Gian Marco Marmoni, Marco Menichetti, Davide Torre, Giulia Iacobucci, Daniela Piacentini   +6 more
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source