Results 31 to 40 of about 911,359 (269)

Paving the way to improve therapy for Myeloproliferative Neoplasms

Nature Communications, 2022
Long-acting IFNα induces durable molecular responses in myeloproliferative neoplasms. Emerging studies, including Saleiro et al. recently published in Nature Communications, have identified promising candidates that may synergise with IFNα by targeting ...
Megan Bywater, Steven W. Lane
doaj   +1 more source

Re‐Irradiation in Pediatric Diffuse Midline Glioma: A Multi‐Institutional Retrospective Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Children with recurrent diffuse midline gliomas (DMGs) have limited therapeutic options at recurrence. Re‐irradiation (RT2) may be used at progression, but with uncertainty about the benefit. Methods We conducted a multi‐institutional retrospective study of children aged < 18 with DMG treated at three centers (Toronto, Canada ...
Ajay Thomas Alex, Sean P. Hassan, Helen Benghiat, Liam Herbert, Jennifer Adamski, Shivani Bailey, Claire Esler, Louise Brookes, Molly Bamber, Grace Koudou, Karen Waite, Julie Bennett, Anirban Das, Derek S. Tsang   +13 more
wiley   +1 more source

Differential Renoprotective Actions of Simvastatin and Rosuvastatin in Streptozotocin-Induced Diabetes in Sprague-Dawley Rat

Archives of Pharmaceutical Sciences Ain Shams University, 2020
Diabetic nephropathy (DN) is the most frequent cause of the end-stage renal disease (ESRD) in about 33% of diabetic patients. The present study aimed to explore the renoprotective effects of simvastatin (SV) and rosuvastatin (RSU) on the kidney of ...
Rowaida Refaat, Asmaa Eldeeb, Marwa Bakir, Eman I El-Abd, Emad El-Bassiouni   +4 more
doaj   +1 more source

Synthetic MRI plus FSE-PROPELLER DWI for differentiating malignant from benign head and neck tumors: a preliminary study

Frontiers in Oncology, 2023
BackgroundPreoperative classification of head and neck (HN) tumors remains challenging, especially distinguishing early cancerogenic masses from benign lesions. Synthetic MRI offers a new way for quantitative analysis of tumors.
Baohong Wen, Zanxia Zhang, Jing Zhu, Liang Liu, Zijun Liu, Xiaoyue Ma, Kaiyu Wang, Lizhi Xie, Yong Zhang, Jingliang Cheng   +9 more
doaj   +1 more source

T2* Magnetic Resonance Imaging Uncovers Hemosiderin Burden in Pediatric Hemophilia: A Call for Sensitive Imaging Biomarkers

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Hemophilic arthropathy remains the leading morbidity in hemophilia despite modern prophylaxis, and early joint damage may be missed by routine exams. This study explored T2* MRI as a noninvasive biomarker of hemosiderin deposition in pediatric hemophilia.
Jessica Garcia, Tarique Hussain, Jeanne Dillenbeck, Matthew Hammer, Annette von Drygalski, Guy Young, Ayesha Zia   +6 more
wiley   +1 more source

Combination of PI-RADS version 2.1 and amide proton transfer values for the detection of clinically significant prostate cancer

BMC Cancer
Background The goal of this study was to assess whether combining amide proton transfer (APT)-weighted MRI with the Prostate Imaging Reporting and Data System scoring system version 2.1 (PI-RADS V2.1) could increase diagnostic accuracy compared to PI ...
Li Zhang, Longchao Li, Xia Zhe, Min Tang, Xiaoyan Lei, Jing Zhang, Xianglong Duan   +6 more
doaj   +1 more source

Clinical, Histopathological, and Molecular Characterization of Pediatric MN1::ZNF341‐Associated Cancer

Pediatric Blood &Cancer, EarlyView.
ABSTRACT A lethal round‐cell malignancy with an MN1::ZNF341 fusion has recently been reported in three infants. Here, we describe four further tumors, three in newborns (including monozygotic twins), and one in an adolescent. Detailed clinical, radiological, and histopathological data differentiate these tumors from their main mimics, neuroblastoma and
Thomas R. W. Oliver, Dyanne Rampling, Barbara Walkowiak, Nathaniel D. Anderson, Manas Dave, Henry Lee‐Six, Sadie Baskind, Pooja Balasubramanian, Glenn Anderson, Conor Parks, Toochi Ogbonnah, Emilia R. Robertson, Simon Hannam, Rohan Verma, John C. Achermann, Liina Palm, Neil Sebire, Thomas Jacques, Tom Watson, Carryl Dryden, Karin Straathof, Mette Jorgensen, Olga Slater, Sam Behjati, Sarita Depani, J. Ciaran Hutchinson   +25 more
wiley   +1 more source

MRI of the penis [PDF]

The British Journal of Radiology, 2012
MRI of the penis is an expensive test that is not always superior to clinical examination or ultrasound. However, it shows many of the important structures, and in particular the combination of tumescence from intracavernosal alprostadil, and high-resolution T  2 sequences show the glans, corpora and the tunica albuginea well.
openaire   +2 more sources

Characterization of changes in the resting-state intrinsic network in patients with diabetic peripheral neuropathy

Scientific Reports
Diabetic peripheral neuropathy (DPN) is the most common complication of type 2 diabetes mellitus (T2DM) and is often accompanied by a variety of cognitive and emotional deficits, but the neurologic mechanisms underlying these deficits have not been fully
Dongsheng Zhang, Yang Huang, Yitong Guan, Xiaoling Zhang, Peichun Pan, Xuejiao Yan, Xiaoyan Lei, Min Tang, Kai Ai, Jie Gao   +9 more
doaj   +1 more source

Comparison of Different Machine Models Based on Contrast-Enhanced Computed Tomography Radiomic Features to Differentiate High From Low Grade Clear Cell Renal Cell Carcinomas

Frontiers in Oncology, 2021
PurposeThis study was to investigate the role of different radiomics models with enhanced computed tomography (CT) scan in differentiating low from high grade renal clear cell carcinomas.Materials and MethodsCT data of 190 cases with pathologically ...
Xu Pei, Ping Wang, Jia-Liang Ren, Xiao-Ping Yin, Xiao-Ping Yin, Lu-Yao Ma, Yun Wang, Xi Ma, Bu-Lang Gao   +8 more
doaj   +1 more source