Results 61 to 70 of about 1,793,451 (304)

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

Altered cortical thickness-based structural covariance networks in type 2 diabetes mellitus

Frontiers in Neuroscience
Cognitive impairment is a common complication of type 2 diabetes mellitus (T2DM), and early cognitive dysfunction may be associated with abnormal changes in the cerebral cortex.
Yang Huang, Xin Zhang, Miao Cheng, Zhen Yang, Wanting Liu, Kai Ai, Min Tang, Xiaoling Zhang, Xiaoyan Lei, Dongsheng Zhang   +9 more
doaj   +1 more source

Circulating tumor cell viability during and after radiotherapy mirrors treatment response in cancer patients

Molecular Oncology, EarlyView.
Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy, Jana Löptien, Cornelia Coith, Afroditi Nanou, Katharina Hintelmann, Pinnschmidt Hans, Cordula Petersen, Klaus Pantel, Sabine Riethdorf, Kerstin Borgmann, Harriet Wikman   +10 more
wiley   +1 more source

MRI changes in psoriatic dactylitisextent of pathology, relationship to tenderness and correlation with clinical indices [PDF]

, 2008
Objectives. To quantify the extent of inflammation in psoriatic dactylitis and to examine the relationship between clinical and magnetic resonance imaging (MRI) data in both tender and non-tender dactylitis. Methods.
Chandramohan, M., Groves, C., Healy, P.J., Helliwell, P.S.   +3 more
core   +1 more source

MRI of myelitis

Journal of the Belgian Society of Radiology, 2012
The diagnosis of myelitis relies on MRI. The purpose of this review is to describe the imaging findings in patients with myelitis through clinical cases. MR findings in Multiple Sclerosis, Neuromyelitis Optica and others Transverse Myelitis are highlighted.
Hodel, J, Outteryck, O, Jissendi, P, Zins, M, Leclerc, X, Pruvo, J P   +5 more
openaire   +5 more sources

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

ASAS definition for sacroiliitis on MRI in SpA : applicable to children? [PDF]

, 2017
Background: The Assessment of Spondyloarthritis International Society (ASAS) definition for a'positive' Magnetic Resonance Imaging (MRI) for sacroiliitis is well studied and validated in adults, but studies about the value of this definition in children ...
Baraliakos, Xenofon, Dehoorne, Jo, Elewaut, Dirk, Herregods, Nele, Jans, Lennart, Jaremko, Jacob Lester, Joos, Rik, Van den Bosch, Filip, Van Vlaenderen, Joke, Varkas, Gaëlle, Verstraete, Koenraad   +10 more
core   +2 more sources

Altered inter-hemispheric and intra-hemispheric functional connectivity dynamics in male cigarette smokers

BMC Psychiatry
Background Previous study has overlooked the heterogeneity between hemispheres and the knowledge of brain temporal dynamics in tobacco use disorder (TUD) individuals was limited.
Mengzhe Zhang, Huiyu Huang, Xiaoyu Niu, Jinghan Dang, Jieping Sun, Qiuying Tao, Weijian Wang, Shaoqiang Han, Jingliang Cheng, Yong Zhang   +9 more
doaj   +1 more source

Altered Functional Connectivity of Insular Subregions in Type 2 Diabetes Mellitus

Frontiers in Neuroscience, 2021
Diabetes-related brain damage can lead to cognitive decline and increase the risk of depression, but the neuropathological mechanism of this phenomenon remains unclear.
Dongsheng Zhang, Man Wang, Jie Gao, Yang Huang, Fei Qi, Yumeng Lei, Kai Ai, Xuejiao Yan, Miao Cheng, Yu Su, Xiaoyan Lei, Xiaoling Zhang   +11 more
doaj   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source