Results 61 to 70 of about 1,766,278 (301)

Intravitreal GD2‐Specific Chimeric Antigen Receptor T‐Cell Therapy for Refractory Retinoblastoma

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Effective treatments for advanced, treatment‐resistant retinoblastoma (RB) remain limited. GD2‐specific chimeric antigen receptor (CAR) T cells show potent antitumor activity with minimal toxicity but have not previously been evaluated in RB.
Subongkoch Subhadhirasakul, Jatuporn Sujjitjoon, Pa‐thai Yenchitsomanus, Kridtin Jarutatsanangkoon, Ng Wei Loon, Kleebsabai Sanpakit, Jassada Buaboonnam, Chayamon Takpradit, Pornpimon Yuti, Nunghathai Sawasdee, Piriya Luangwattananun, Siripakorn Sangkitporn, Arnan Limmahachai, La‐ongsri Atchaneeyasakul   +13 more
wiley   +1 more source

Altered cortical thickness-based structural covariance networks in type 2 diabetes mellitus

Frontiers in Neuroscience
Cognitive impairment is a common complication of type 2 diabetes mellitus (T2DM), and early cognitive dysfunction may be associated with abnormal changes in the cerebral cortex.
Yang Huang, Xin Zhang, Miao Cheng, Zhen Yang, Wanting Liu, Kai Ai, Min Tang, Xiaoling Zhang, Xiaoyan Lei, Dongsheng Zhang   +9 more
doaj   +1 more source

The Fate (Outcome) of Clinically Apparent Single Lesion and Oligofocal Nephroblastomatosis Treated According to SIOP/GPOH Protocols for Wilms Tumor

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background The management of clinically apparent single lesions or oligofocal nephroblastomatosis, a facultative precursor of nephroblastoma, remains debated. Methods We retrospectively analyzed 37 patients with clinically apparent single or oligofocal nephroblastomatosis (two to three lesions per kidney) among 2347 patients registered between
Nils Welter, Jens‐Peter Schenk, Jenny Wegert, Manfred Gessler, Leo Kager, Stefan Wagenpfeil, Marina Müller, Jean‐Michel Wolff, Joerg Fuchs, Steven W. Warmann, Clemens‐Magnus Meier, Jochen Hubertus, Christian Rübe, Christian Vokuhl, Patrick Melchior, Lena Tschirner, Norbert Graf, Rhoikos Furtwängler   +17 more
wiley   +1 more source

MRI changes in psoriatic dactylitisextent of pathology, relationship to tenderness and correlation with clinical indices [PDF]

, 2008
Objectives. To quantify the extent of inflammation in psoriatic dactylitis and to examine the relationship between clinical and magnetic resonance imaging (MRI) data in both tender and non-tender dactylitis. Methods.
Chandramohan, M., Groves, C., Healy, P.J., Helliwell, P.S.   +3 more
core   +1 more source

Altered inter-hemispheric and intra-hemispheric functional connectivity dynamics in male cigarette smokers

BMC Psychiatry
Background Previous study has overlooked the heterogeneity between hemispheres and the knowledge of brain temporal dynamics in tobacco use disorder (TUD) individuals was limited.
Mengzhe Zhang, Huiyu Huang, Xiaoyu Niu, Jinghan Dang, Jieping Sun, Qiuying Tao, Weijian Wang, Shaoqiang Han, Jingliang Cheng, Yong Zhang   +9 more
doaj   +1 more source

Potential effects of peripheral neuropathy on brain function in patients with type 2 diabetes mellitus

Frontiers in Endocrinology
BackgroundThe mechanisms associated between diabetic peripheral neuropathy (DPN) and various brain function abnormalities in patients remains unclear. This study attempted to indirectly evaluate the effect of DPN on brain function in patients with type 2
Dongsheng Zhang, Yang Huang, Xiaoling Zhang, Wanting Liu, Yitong Guan, Jie Gao, Xiaoyan Lei, Min Tang, Kai Ai, Xuejiao Yan   +9 more
doaj   +1 more source

Altered Functional Connectivity of Insular Subregions in Type 2 Diabetes Mellitus

Frontiers in Neuroscience, 2021
Diabetes-related brain damage can lead to cognitive decline and increase the risk of depression, but the neuropathological mechanism of this phenomenon remains unclear.
Dongsheng Zhang, Man Wang, Jie Gao, Yang Huang, Fei Qi, Yumeng Lei, Kai Ai, Xuejiao Yan, Miao Cheng, Yu Su, Xiaoyan Lei, Xiaoling Zhang   +11 more
doaj   +1 more source

MRI and clinical resolution of a suspected intracranial toxoplasma granuloma with medical treatment in a domestic short hair cat [PDF]

, 2017
A two-year-old cat was presented with a left paradoxical vestibular syndrome. MRI of the brain revealed an extra-axial homogenously contrast enhancing mass in the region of the left caudal cerebellar peduncle.
Beltran, E, Crawford, A H, Drees, R
core   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

The Role of the Magnetorotational Instability in the Sun [PDF]

, 2014
We calculate growth rates for nonaxisymmetric instabilities including the magnetorotational instability (MRI) throughout the Sun. We first derive a dispersion relation for nonaxisymmetric instability including the effects of shear, convective buoyancy ...
Kagan, Daniel, Wheeler, J. Craig
core   +2 more sources