Results 101 to 110 of about 30,943 (238)

Unlocking binding properties of single-domain antibodies targeting the polymeric immunoglobulin receptor to enhance mucosal enrichment of IgG against respiratory syncytial virus

Frontiers in Immunology
A major driver of mucosal immunity is immunoglobulin A (IgA) that can translocate across mucosal epithelial barriers to protect against various pathogens in luminal spaces of the human body.
Jia Liu, Jiwon Jung, Siqun Zhou, Shi-Juan Chen, Jiping Huang, Yinyan Tang, Karin Vroom, Soha Motlagh, Daoyang Chen, Huong Trinh, Peter Worthington, Daphne Y. Ma, Zhiyun Wen, Bin Luo, Daniela Bumbaca Yadav, Jia Yao Phuah, Zhifeng Chen, Kalpit A. Vora, Masahisa Handa   +18 more
doaj   +1 more source

Pharmacokinetics of monoclonal antibodies and Fc-fusion proteins

Protein & Cell, 2017
There are many factors that can influence the pharmacokinetics (PK) of a mAb or Fc-fusion molecule with the primary determinant being FcRn-mediated recycling.
Liming Liu
doaj   +1 more source

Presence of Nationally Banned Carbamates and Organophosphate Pesticides in Wild Carnivores, Southeastern Brazil

Environmental Toxicology, EarlyView.
ABSTRACT As top predators, terrestrial carnivores face great risk of pesticide exposure and serve as sentinels of environmental contamination. Additionally, terrestrial carnivores are frequently threatened by intentional or secondary poisoning with highly toxic compounds, such as carbamates and organophosphates.
Marina Pellegrino da Silva, Vagner Gonçalves‐Junior, Mauricio Candido da Silva, André Rinaldi Fukushima, Rose Lilian Gasparini‐Morato, Helenice de Souza Spinosa, Ana Carolina Ewbank, Carlos Sacristán, Ana de la Torre, José Luiz Catão‐Dias, Pedro Enrique Navas‐Suárez   +10 more
wiley   +1 more source

Phenotype of ovarian mast cells in neonatal MRL/MpJ mice.

, 2018
(A) AB/SO sections of neonatal MRL/MpJ mice. (B) TEM examination of neonatal ovarian MCs in MRL/MpJ mice. (C) Expression levels of MMC marker Mcpt2, CTMC marker Tpsb2, and Mcpt2 normalized by Tpsb2.
Ken-ichi Nagasaki (5130728), Yaser Hosny Ali Elewa (5130725), Yasuhiro Kon (58978), Teppei Nakamura (466554), Masataka Chihara (582172), Osamu Ichii (339354), Saori Otsuka-Kanazawa (582171), Osamu Tatsumi (5130731)   +7 more
core   +1 more source

The 5T Paradox of Triclosan: From Toiletries to Toxic Trash, a Growing Threat to Humanity

Environmental Toxicology, EarlyView.
ABSTRACT Triclosan (TCS) persists as a contaminant of concern in the Anthropocene, despite regulatory actions. Environmental dissemination continues through wastewater effluents, biosolid application, and improper disposal practices. This narrative review synthesizes current evidence regarding triclosan's environmental fate, transformation pathways ...
Temitope Aribigbola, Mauro Ricardo Souza da Luz, Sunday Amos Onikanni, Marjorie Dardis Murucci, Oluwatosin Stella Olayinka, Rodrigo Soares Fortunato, Rômulo Sperduto Dezonne, Omolola Esther Amos, Sara Gemini Piperni, Denise Pires de Carvalho, Leandro Miranda‐Alves   +10 more
wiley   +1 more source

Enhanced functional recovery after SCI in MRL/MpJ mice.

, 2012
a, The latency to fall off the rotarod is depicted as a function of time for intact (baseline) and injured MRL/MpJ and C57BL/6 mice. In both strains intact mice improved their performance over the course of the 88 days of training, but the C57BL/6 ...
Sandrine Thuret (119458), Laura L. Horky (183733), Michaela Thallmair (183731), Fred H. Gage (183736)   +3 more
core   +1 more source

Evidence for articular cartilage regeneration in MRL/MpJ mice [PDF]

, 2008
SummaryObjectiveA major clinical problem in Orthopaedics is the repair of traumatic articular cartilage lesions. The MRL/MpJ strain of mice has the remarkable ability to regenerate ear hole punch wounds seamlessly including the scarless replacement of ...
Herzka, A.S., Rich, C., Fitzgerald, J., Burkhardt, D., Allen, J., Little, C.B.   +5 more
core   +1 more source

Assessment of Metal Contamination and Human Health Risk in the Buffalo River Estuary, Eastern Cape, South Africa

Environmental Toxicology, EarlyView.
ABSTRACT Metal contamination in estuarine environments poses environmental and public health concerns, particularly where surface waters support domestic and subsistence uses. This study assessed the seasonal distribution, controlling mechanisms, and non‐carcinogenic health risks of selected metals (Mg, Al, Ba, Fe, Mn, and Zn) in the Buffalo River ...
Motebang D. V. Nakin, Tolulope Elizabeth Aniyikaiye, Akinola Ikudayisi   +2 more
wiley   +1 more source

Genomics‐informed management of ex situ populations

Conservation Biology, EarlyView.
Abstract The European Association of Zoos and Aquariums (EAZA) manages insurance populations for hundreds of species through its EAZA ex situ programs (EEPs). EEPs help safeguard against extinction in the wild and provide source populations for genetic rescue programs.
Cock van Oosterhout, Philippe Helsen, Elmar Fienieg, Claudia Fontsere, Linett Rasmussen, Mirte Bosse, Zjef Pereboom, Christina Hvilsom, Hernán E. Morales   +8 more
wiley   +1 more source

Living with diabetes in the Brazilian Amazon: Exploring barriers and supports for healthy lifestyle practices

Diabetic Medicine, EarlyView.
Abstract Aims To investigate the barriers and facilitators to adopting healthy lifestyle habits among patients with type 2 diabetes mellitus (T2DM) in the Brazilian Amazon, using the Environmental Factors domain of the International Classification of Functioning, Disability and Health (ICF) as a conceptual framework.
Thalyta Mariany Rêgo Lopes Ueno, Tiago Assunção dos Santos Farias, Wagner Ferreira Monteiro, Maria Paula dos Santos, Hércules Lázaro Morais Campos, Elisa Brosina de Leon   +5 more
wiley   +1 more source