Results 131 to 140 of about 30,943 (238)
ABSTRACT The aggregation of human islet amyloid polypeptide (hIAPP) into cytotoxic oligomers and amyloid fibrils is a hallmark of type 2 diabetes mellitus (T2DM), leading to pancreatic β‐cell dysfunction. In contrast, rat IAPP (rIAPP) is largely non‐amyloidogenic. Osmolytes such as glucose, glycerol, and sorbitol are known to stabilize globular protein
Kiara A. Kidman +3 more
wiley +1 more source
The highly expanded TCRβ+ DNT cells in autoimmune‐prone B6/lpr mice are phenotypically and functionally different from the TCRβ+DNT cells of normal B6 mice. Conditional Egr2 deletion in B6/lpr mice not only reduces TCRβ+ DNT cell numbers but also tends to correct the phenotypic and functional abnormalities of DNT cells in B6/lpr mice. In addition, Egr2
Rujuan Dai +4 more
wiley +1 more source
ABSTRACT In finfish aquaculture, there are several inflammatory diseases impacting productivity and animal welfare, however there are limited options available to veterinarians to treat inflammation and pain in fish. Nonsteroidal anti‐inflammatory drugs (NSAIDs) are widely used in terrestrial animals raised for human consumption to treat a range of ...
Chloe J. English +4 more
wiley +1 more source
A trait‐based integration of competition and abiotic tolerance underlies plant success
Competitive effect and abiotic tolerance show positive associations with species' niche breadth and local dominance. Summary Understanding what determines species' ecological success is a central challenge in ecology. Competitive ability and abiotic tolerance are expected to be strong predictors of species success, yet theory predicts a trade‐off ...
Jan Douda +7 more
wiley +1 more source
MAGNETIC RESONANCE LYMPHOGRAPHY (MRL): POINT AND COUNTER-POINT
Two preeminent lymphologists debatethe findings, implications, interpretations, andvalue of magnetic resonance lymphography(MRL) in the evaluation of peripherallymphedema.
Olszewski, W
core +1 more source
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Fecal microbiota from MRL/Lpr mice exacerbates pristane induced lupus
The 16s rRNA sequence and metagenome sequencing of the gut microbiome of the the pristane-induced lupus mice with fecal microbiota transplantation from MRL/Lpr mice or MRL/Mpj ...
Yi, X
core +1 more source
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
Large scale retrieval for the LinkedIn feed using causal language models
Abstract In large‐scale recommendation systems like LinkedIn's, the retrieval stage is critical for narrowing billions of potential candidates to a manageable subset for ranking. LinkedIn's feed now serves suggested content based on the topical interests of members, where 2000 candidates are retrieved from several million candidates with a latency ...
Sudarshan Srinivasa Ramanujam +23 more
wiley +1 more source
Abstract Industrial hemp's return to American agriculture has been accompanied by claims of the crop's carbon neutrality, primarily due to its commercial applications. While carbon can be sequestered within products made with hemp fiber, there is little empirical evidence quantifying greenhouse gas contributions from the crop's production.
Kent Pham +4 more
wiley +1 more source

