Results 131 to 140 of about 30,943 (238)

Impact of Stabilizing Osmolytes on the Conformational Dynamics of Human and Rat Islet Amyloid Polypeptides

open access: yesProteins: Structure, Function, and Bioinformatics, Volume 94, Issue 10, Page 1717-1737, October 2026.
ABSTRACT The aggregation of human islet amyloid polypeptide (hIAPP) into cytotoxic oligomers and amyloid fibrils is a hallmark of type 2 diabetes mellitus (T2DM), leading to pancreatic β‐cell dysfunction. In contrast, rat IAPP (rIAPP) is largely non‐amyloidogenic. Osmolytes such as glucose, glycerol, and sorbitol are known to stabilize globular protein
Kiara A. Kidman   +3 more
wiley   +1 more source

The Transcription Factor EGR2 Plays a Central Role in the Expansion and Function of TCRαβ + CD4 − CD8 − Double Negative T Cells in lpr Lupus Mice

open access: yesImmunology, Volume 179, Issue 2, Page 224-235, October 2026.
The highly expanded TCRβ+ DNT cells in autoimmune‐prone B6/lpr mice are phenotypically and functionally different from the TCRβ+DNT cells of normal B6 mice. Conditional Egr2 deletion in B6/lpr mice not only reduces TCRβ+ DNT cell numbers but also tends to correct the phenotypic and functional abnormalities of DNT cells in B6/lpr mice. In addition, Egr2
Rujuan Dai   +4 more
wiley   +1 more source

A Review of Nonsteroidal Anti‐Inflammatory Drugs for Food‐Producing Animals With a Focus on Potential Applications for Farmed Finfish

open access: yesJournal of Fish Diseases, Volume 49, Issue 10, October 2026.
ABSTRACT In finfish aquaculture, there are several inflammatory diseases impacting productivity and animal welfare, however there are limited options available to veterinarians to treat inflammation and pain in fish. Nonsteroidal anti‐inflammatory drugs (NSAIDs) are widely used in terrestrial animals raised for human consumption to treat a range of ...
Chloe J. English   +4 more
wiley   +1 more source

A trait‐based integration of competition and abiotic tolerance underlies plant success

open access: yesNew Phytologist, Volume 252, Issue 1, Page 87-99, October 2026.
Competitive effect and abiotic tolerance show positive associations with species' niche breadth and local dominance. Summary Understanding what determines species' ecological success is a central challenge in ecology. Competitive ability and abiotic tolerance are expected to be strong predictors of species success, yet theory predicts a trade‐off ...
Jan Douda   +7 more
wiley   +1 more source

MAGNETIC RESONANCE LYMPHOGRAPHY (MRL): POINT AND COUNTER-POINT

open access: yes, 2013
Two preeminent lymphologists debatethe findings, implications, interpretations, andvalue of magnetic resonance lymphography(MRL) in the evaluation of peripherallymphedema.
Olszewski, W
core   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, Volume 20, Issue 9, Page 2203-2219, September 2026.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

Fecal microbiota from MRL/Lpr mice exacerbates pristane induced lupus

open access: yes
The 16s rRNA sequence and metagenome sequencing of the gut microbiome of the the pristane-induced lupus mice with fecal microbiota transplantation from MRL/Lpr mice or MRL/Mpj ...
Yi, X
core   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

open access: yesMolecular Oncology, Volume 20, Issue 9, Page 2188-2202, September 2026.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena   +15 more
wiley   +1 more source

Large scale retrieval for the LinkedIn feed using causal language models

open access: yesAI Magazine, Volume 47, Issue 3, Fall 2026.
Abstract In large‐scale recommendation systems like LinkedIn's, the retrieval stage is critical for narrowing billions of potential candidates to a manageable subset for ranking. LinkedIn's feed now serves suggested content based on the topical interests of members, where 2000 candidates are retrieved from several million candidates with a latency ...
Sudarshan Srinivasa Ramanujam   +23 more
wiley   +1 more source

Substitution of fiber hemp for corn did not affect soil greenhouse gas emissions from a Kentucky cropping system

open access: yesAgrosystems, Geosciences &Environment, Volume 9, Issue 3, September 2026.
Abstract Industrial hemp's return to American agriculture has been accompanied by claims of the crop's carbon neutrality, primarily due to its commercial applications. While carbon can be sequestered within products made with hemp fiber, there is little empirical evidence quantifying greenhouse gas contributions from the crop's production.
Kent Pham   +4 more
wiley   +1 more source

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