Results 131 to 140 of about 33,403 (259)

MGtree: A Fast and Flexible Alignment-Based Metagenomics Pipeline

Viruses
Metagenomics analysis is a critical tool in identifying and typing viral samples to aid surveillance, clinical, epidemiological, and other workflows. Despite advances in sequencing technology and analysis pipelines, there are still limitations that lead ...
Samantha L. Sholes, Scott Norton, Alfredo Gonzalez, John M. Gaspar   +3 more
doaj   +1 more source

Effects of Gal-9 on lupus nephritis in MRL/lpr mice.

, 2013
(A) Comparison of proteinuria between PBS-treated (PBS) and Gal-9-treated (Gal-9) MRL/lpr lupus-prone mice. Gal-9 and PBS were injected intraperitoneally into 9-week-old MRL/lpr lupus-prone mice 3-times/week until they were 20 weeks of age.
Tsutomu Masaki (121136), Hirohito Mori (314652), Hideki Kobara (400974), Masakazu Kohno (400975), Mitsuomi Hirashima (68149), Toshiro Niki (121127), Genichiro Soma (400973), Daisuke Nakano (314646), Masahiro Moritoki (400972), Takeshi Kadowaki (121129)   +9 more
core   +1 more source

Neurotransmitter‐Defined Degeneration Patterns in Sporadic and C9orf72‐Associated Amyotrophic Lateral Sclerosis: Predilection to GABAergic, Serotonergic, Opioid, Glutamatergic, Endocannabinoid, and Microglial Systems—Implications for Therapy Development

Annals of Neurology, Volume 100, Issue 5, Page 948-961, November 2026.
Objective Amyotrophic lateral sclerosis (ALS) has a markedly distinctive clinical and neuroradiological signature, with the preferential involvement of specific brain networks and the apparent sparing of others. The molecular underpinnings of the strikingly selective anatomical vulnerability have not been fully elucidated to date despite the potential ...
Marlene Tahedl, We Fong Siah, Jasmin Lope, Jennifer C. Hengeveld, Mark A. Doherty, Russell L. McLaughlin, Orla Hardiman, Ee Ling Tan, Alison Toomey, Jana Kleinerova, Peter Bede   +10 more
wiley   +1 more source

Imbalance towards Th1 predominance is associated with acceleration of lupus-like autoimmune syndrome in MRL mice.

, 1996
To investigate the respective roles of Th1 and Th2 cells in the pathogenesis of lupus-like autoimmune disease, we have analyzed the spontaneous and antigen-induced productions of IgG1 vs IgG2a and IgG3 subclasses in relation to the mRNA expression of INF-
M Iwamoto, Takahashi, Satoru, L Fossati, Merino, Ramon, Motta, R., S Takahashi, Fossati-Jimack, Liliane, R Merino, T Kobayakawa, Kobayakawa, T., Iwamoto, Masahiro, R Motta, S Izui, Izui, Shozo, Iwamoto M, Izui S, Kobayakawa T, Merino R, Motta R, Takahashi S, Fossati L   +20 more
core   +1 more source

Neutrophil Extracellular Traps Block Fibrinolysis in Ischemic Stroke

Annals of Neurology, Volume 100, Issue 5, Page 964-978, November 2026.
Objectives Intravenous thrombolysis (IVT) failure in acute ischemic stroke (AIS) is frequent, but its causes remain elusive. We investigated whether biologically relevant intrathrombus concentrations of tissue plasminogen activator (tPA) were achieved in failed IVT and whether neutrophil extracellular traps (NETs) contributed to this therapeutic ...
Mialitiana Solo Nomenjanahary, Jean‐Philippe Desilles, Fatima Zemali, Astride Perrot, Lucas Di Meglio, Sara Zalghout, Jéromine Fasille, Jérémy Neel, Stéphane Loyau, Julien Labreuche, Marie‐Charlotte Bourrienne, Dorothée Faille, François Delvoye, Véronique Ollivier, Sébastien Dupont, Jasmina Rogozarski, Nahida Brikci‐Nigassa, Robert L. Medcalf, Nadine Ajzenberg, Mikael Mazighi, Benoît Ho‐Tin‐Noé, the compoCLOT Study Group   +21 more
wiley   +1 more source

Interferon regulatory factor 5 is critical for the development of lupus in MRL/lpr mice

, 2011
Objective. Interferon regulatory factor 5 (IRF-5) is a transcription factor that mediates intracellular signals activated by engagement of Toll-like receptors (TLRs). IRF5 polymorphisms are associated with an increased or decreased risk of systemic lupus
Inoue, Hisako, Kondo, Seiji, Seiji Kondo, Tada, Yoshifumi, Tak W. Mak, Koarada, Syuichi, Suematsu, Rie, Rie Suematsu, Yoshifumi Tada, Syuichi Koarada, Akihide Ohta, Shigehisa Aoki, Nagasawa, Kohei, Mak, Tak W., Aoki, Shigehisa, Hisako Inoue, Kohei Nagasawa, Ohta, Akihide   +17 more
core   +1 more source

MARCH5 Links Hypoxia to Neutrophil Ferroptosis in SLE via FSP1 Ubiquitination

Immunity, Inflammation and Disease, Volume 14, Issue 11, November 2026.
ABSTRACT Purpose Ferroptosis plays an important role in the progression of systemic lupus erythematosus (SLE). This study aims to investigate the molecular mechanism by which membrane‐associated RING‐CH‐type finger protein 5 (MARCH5) regulates ferroptosis suppressor protein 1 (FSP1), a key regulator of ferroptosis resistance, under hypoxic conditions ...
Jing Zhang, Fulin Cai, Jiansen Lu, Zhiwei Liu   +3 more
wiley   +1 more source

HPV Serology and Circulating Viral DNA for Detection, Genotyping, and Measurement of Disease Burden in Oropharyngeal Cancer

International Journal of Cancer, Volume 159, Issue 9, Page 2336-2346, 1 November 2026.
ABSTRACT The incidence of human papillomavirus‐positive (HPV+) oropharyngeal cancer (OPC) has increased rapidly, and HPV early antigen serology has been proposed as a scalable and cost‐effective early detection test. HPV seropositivity can precede clinical presentation of OPC by several years, so additional surveillance procedures may be necessary to ...
Lucas Penny, Eric Yang Stutheit‐Zhao, Birgitta E. Michels, Fabian Rosing, Zhen Zhao, Yangqiao Zheng, Jinfeng Zou, Shao Hui Huang, Johnny Carlton, Andrew McPartlin, John R. de Almeida, David Goldstein, Andrew Hope, Ali Hosni, John Kim, Fei‐Fei Liu, C. Jillian Tsai, John N. Waldron, Anna Spreafico, Enrique Sanz‐Garcia, Lillian L. Siu, Tim Waterboer, Geoffrey Liu, Scott V. Bratman   +23 more
wiley   +1 more source

MRL/MpJ-Fas^lpr mice show abnormalities in ovarian function and morphology with the progression of autoimmune disease

, 2015
The immune system is known to affect reproductive function, and maternal–fetal immune tolerance is essential for a successful pregnancy. To investigate the relationship between autoimmune disease and female reproductive function, we performed a ...
Yasuhiro Kon (58978), Masataka Chihara (582172), Teppei Nakamura (466554), Yuki Otani (808505), Osamu Ichii (339354), Saori Otsuka-Kanazawa (582171)   +5 more
core   +1 more source

Half a Century of Per‐ and Polyfluoroalkyl Substances in Northern Gannet Eggs: Impact of Regulations

Journal of Applied Toxicology, Volume 46, Issue 11, Page 4085-4098, November 2026.
ABSTRACT Per‐ and polyfluoroalkyl substances (PFAS), known as “forever chemicals”, are persistent organic pollutants that have been widely used in the industry across the globe for many decades. Their chemical stability, bioaccumulation, and toxicity pose major environmental and health risks. This study examines temporal trends in the concentrations of
Anaïs Fournier, Anaïs Kerric, Raphaël A. Lavoie   +2 more
wiley   +1 more source