Smart Design: Integrating Artificial Intelligence and Gene Editing for Advanced mRNA Therapeutics
The challenges of mRNA therapy and the application of artificial intelligence and gene editing in the field of mRNA drugs. ABSTRACT Artificial intelligence (AI) and gene editing are increasingly being applied to the design and evaluation of mRNA therapeutics.
Haixing Shi +11 more
wiley +1 more source
Use of conversion factors for the setting of MRLs of prothioconazole. [PDF]
European Food Safety Authority (EFSA) +18 more
europepmc +1 more source
Autoimmunity: Molecular Mechanisms, Biomarkers, and Therapeutic Opportunities
Major types of immunometabolism, epigenetics, posttranscriptional regulation, and functional reprogramming involved in autoimmune diseases. The roles of immunometabolism, epigenetics, posttranscriptional regulation, and functional reprogramming in autoimmune diseases have been a major research focus in recent years.
Jialong Kuang +10 more
wiley +1 more source
Setting of import tolerance for folpet in bananas and modification of the existing maximum residue level in honey. [PDF]
European Food Safety Authority (EFSA) +10 more
europepmc +1 more source
Role of Tertiary Lymphoid Structures in Autoimmune Diseases and Cancer
Schematic overview of tertiary lymphoid structures (TLSs): The development process, detection, and the immune function that depends on the environment in different disease contexts of TLS. TLSs originate from loose lymphoid aggregates that acquire ordered follicular architecture to become primary follicular‐like TLS, before maturing into ...
Ze Yan +11 more
wiley +1 more source
Review of the existing maximum residue levels for clopyralid according to Article 12 of Regulation (EC) No 396/2005. [PDF]
European Food Safety Authority (EFSA) +8 more
europepmc +1 more source
Applications of Mesenchymal Stromal Cells for Treatment of Diseases
This schematic summarizes the major therapeutic mechanisms of MSCs across different disease systems and highlights factors associated with MSCs dysfunction, together with current strategies to enhance MSCs function and therapeutic efficacy. This summary diagram illustrates that MSCs exert therapeutic effects in various diseases through multiple ...
Dongmei Xue, Yongsheng Li, Lei Wu
wiley +1 more source
Modification of the existing maximum residue levels for acequinocyl in celeries, Florence fennel and rhubarb. [PDF]
European Food Safety Authority (EFSA) +10 more
europepmc +1 more source
ABSTRACT Background Enhanced recovery after surgery (ERAS) protocols are multimodal perioperative pathways designed to reduce surgical stress, accelerate recovery, and improve resource utilization. Although ERAS principles have been increasingly adopted in microsurgery, their application in vascularized lymph node transfer (VLNT), particularly using ...
Federico Lo Torto +4 more
wiley +1 more source
Improving polarized neutron reflectometry experiments on soft-matter samples: optimization of the solid substrate structure. [PDF]
Yakimenko IP +14 more
europepmc +1 more source

