Results 121 to 130 of about 12,036 (203)

Impact of Stabilizing Osmolytes on the Conformational Dynamics of Human and Rat Islet Amyloid Polypeptides

Proteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT The aggregation of human islet amyloid polypeptide (hIAPP) into cytotoxic oligomers and amyloid fibrils is a hallmark of type 2 diabetes mellitus (T2DM), leading to pancreatic β‐cell dysfunction. In contrast, rat IAPP (rIAPP) is largely non‐amyloidogenic. Osmolytes such as glucose, glycerol, and sorbitol are known to stabilize globular protein
Kiara A. Kidman, Claudio Pedrick, Cara A. Kreck, Ricardo L. Mancera   +3 more
wiley   +1 more source

Architecting and Industrializing Advanced Production and Manufacturing Systems for Critical Industries

Systems Engineering, EarlyView.
ABSTRACT Advanced production systems play a vital role in modern society. Such systems are developed and industrialized over multiple years and at great expense. The complexities of these systems are exacerbated in the case of metal additive manufacturing, which involves numerous process variables and relies on various auxiliary systems.
Duncan W. Gibbons, Andre F. van der Merwe   +1 more
wiley   +1 more source

Multi‐Vine Disease Prediction in a Field Test Spanning Whole Growth Season at Wine‐Industrial Site (McLaren Vale)

Artificial Intelligence for Engineering, EarlyView.
Overall, the findings provide reliable evidence for block‐level disease early warning, inspection prioritisation, and spray decision‐making, helping to reduce unnecessary inputs, lower environmental burdens, and improve the resilience and sustainability of vineyard production systems.
Shu Liang, Nguyen Van Duc Long, Mst Irin Parvin, Philip Kwong, Vinay Pagay, Maria Maglieri, Steve Maglieri, Andrew Godfrey, Harpinder Sandhu, Kartheek Munigoti, Nicola Sasanelli, Pieter van Schalkwyk, Freya Richardson, Bhola Paudel, Pramod Gautam, Kashif Khaqan, Volker Hessel   +16 more
wiley   +1 more source

Anthelmintics residues in milk and dairy products from cows treated with levamisole, oxyclozanide and nitroxynil at different administration doses

, 2010
Anthelmintic drugs are widely used in veterinary medicine for protecting or treating animals mainly against gastrointestinal nematodes and trematodes.
Chirollo, Claudia
core  

Aptamer‐mediated outer membrane destabilization overcomes low permeability resistance in Pseudomonas aeruginosa

The FEBS Journal, EarlyView.
DNA aptamers, Apt 60 and Apt 173, target the BamA protein to compromise outer membrane integrity in Pseudomonas aeruginosa, making it susceptible to Azithromycin, an antibiotic that is otherwise poorly effective due to the low‐permeability membrane.
Rupany Selvam, Michelle Khai Khun Yap, Rafael Giacomazzi, Sérgio F. Sousa, Hock Siew Tan   +4 more
wiley   +1 more source

The Transcription Factor EGR2 Plays a Central Role in the Expansion and Function of TCRαβ+CD4−CD8− Double Negative T Cells in lpr Lupus Mice

Immunology, EarlyView.
The highly expanded TCRβ+ DNT cells in autoimmune‐prone B6/lpr mice are phenotypically and functionally different from the TCRβ+DNT cells of normal B6 mice. Conditional Egr2 deletion in B6/lpr mice not only reduces TCRβ+ DNT cell numbers but also tends to correct the phenotypic and functional abnormalities of DNT cells in B6/lpr mice. In addition, Egr2
Rujuan Dai, Zhuang Wang, Bettina Heid, Christopher M. Reilly, S. Ansar Ahmed   +4 more
wiley   +1 more source

A Review of Nonsteroidal Anti‐Inflammatory Drugs for Food‐Producing Animals With a Focus on Potential Applications for Farmed Finfish

Journal of Fish Diseases, EarlyView.
ABSTRACT In finfish aquaculture, there are several inflammatory diseases impacting productivity and animal welfare, however there are limited options available to veterinarians to treat inflammation and pain in fish. Nonsteroidal anti‐inflammatory drugs (NSAIDs) are widely used in terrestrial animals raised for human consumption to treat a range of ...
Chloe J. English, Christine Huynh, William Roy, James W. Wynne, Hamish Rodger   +4 more
wiley   +1 more source

Liquidity Crises and the Market‐Maker of Last Resort

Journal of Money, Credit and Banking, EarlyView.
Abstract We study market illiquidity in an economy subject to nonfundamental shocks. Asset trading occurs via decentralized bargaining. The model has multiple rational expectations equilibria; we associate certain Pareto‐inferior equilibria with liquidity crises.
CHARLES M. KAHN, DAVID MARSHALL, ROBERT L. MCDONALD   +2 more
wiley   +1 more source

Assessment of the pesticide active substance carvone (d‐/l‐carvone at a ratio of at least 100:1) for inclusion in Annex IV of Regulation (EC) No 396/2005

EFSA Journal, 2016
According to Article 12 of Regulation (EC) No 396/2005, the European Food Safety Authority (EFSA) was required to review the maximum residue levels (MRLs) currently established at European level for the pesticide active substance carvone (d‐/l‐carvone at
European Food Safety Authority (EFSA)
doaj   +1 more source

Pesticide Supply Chains From China to Australia: Examining Paraquat Amid the Global Pesticide Complex

Journal of Agrarian Change, EarlyView.
ABSTRACT Following recent calls to deepen understanding of the Global Pesticide Complex, this article delves into the China‐to‐Australia supply chain of a single herbicide—paraquat. First released in the United Kingdom in the 1960s, acutely toxic paraquat is now primarily produced in China.
Sarah Rogers, Yue Zhao, Sonia Graham, Brooke Wilmsen, Ju‐Han Zoe Wang   +4 more
wiley   +1 more source