Results 161 to 170 of about 12,036 (203)

From Concept to Clinic: Pre‐Clinical Testing and Regulatory Considerations in Spine Implant Development

JOR SPINE, Volume 9, Issue 2, June 2026.
Spine implant development follows a regulated, iterative pathway from clinical need and design through material selection, prototyping, preclinical validation, and regulatory approval to post‐market surveillance. Biomechanical evaluation and risk‐based frameworks integrate across all stages, ensuring safe, effective translation from concept to clinical
Amit Benady, Jerrin Thadathil Varghese, Ryan David Quarrington, Morsi Khashan, B. Gangadhara Prusty, Ashish Diwan   +5 more
wiley   +1 more source

Prognostic Value of Impaired Vocal Cord Mobility in T2N0 Glottic Cancer Treated With IMRT

The Laryngoscope, Volume 136, Issue 6, Page 2605-2613, June 2026.
T2N0M0 glottic cancers with impaired vocal cord mobility (VCM) have worse outcomes than T2N0M0 tumors with normal VCM, but still fare better than T3N0M0 disease. These findings support subdivision of T2 glottic cancer into T2a (normal VCM) and T2b (impaired VCM) in future TNM revisions.
Alexander Rühle, Ranjan Subramani, Jie Su, Brian O'Sullivan, John N. Waldron, Andrew Hope, Andrew Bayley, Andrew McPartlin, Nauman Malik, Scott V. Bratman, Ali Hosni, John Kim, Ian Witterick, John R. de Almeida, Christopher Yao, Anna Spreafico, C. Jillian Tsai, Li Tong, Wei Xu, Shao Hui Huang, Ezra Hahn   +20 more
wiley   +1 more source

Stearoyl‐CoA Desaturase‐1 Drives Tumor Growth by Interacting With Histone Deacetylase‐2 and Deacetylating Nucleophosmin‐1

MedComm, Volume 7, Issue 6, June 2026.
Hypoxia induces SCD1 and PLIN2 to drive lipid droplet‐dependent metabolic adaptation in cancer cells. PLIN2 supports survival under stress, whereas SCD1 promotes proliferation upon reoxygenation and remodels the acetylome via HDAC2‐mediated NPM1 deacetylation and destabilization.
Coline Wery, Laetitia Montero‐Ruiz, Eric Bonneil, Mohammad Farran, Robin Jehay, Quentin Herrara Garfia, Gregory Fettweis, Silvia Blacher, Charles Pottier, Gael Cobraiville, Yasmine Boumahd, Olivier Peulen, Agnès Noël, Franck Dequiedt, Marianne Fillet, Nor Eddine Sounni   +15 more
wiley   +1 more source

Evaluation of confirmatory data following the Article 12 MRL review for isoxaben. [PDF]

EFSA J
European Food Safety Authority (EFSA), Bellisai G, Bernasconi G, Carrasco Cabrera L, Castellan I, Del Aguila M, Ferreira L, Greco L, Leuschner R, Mioč A, Nave S, Reich H, Ruocco S, Scarlato AP, Szot M, Theobald A, Tiramani M, Verani A, Zioga E.   +18 more
europepmc   +1 more source

Detection of Different Pesticide Residues in Seasonal Leafy Vegetables of North Bengal Region, Bangladesh

Public Health Challenges, Volume 5, Issue 2, June 2026.
FTIR spectroscopy detected multiple pesticide residues—thiamethoxam, carbendazim, mancozeb + metalaxyl, and dimethoate—in commonly consumed leafy vegetables from North Bengal, Bangladesh. These findings highlight potential food safety risks and emphasize the need for regular monitoring and safer pesticide management practices.
Md. Mejbah Uddin Mithu, Sadia Akter Shormela, Md. Shahinul Islam, Mahfuza Mubarak   +3 more
wiley   +1 more source

Cluster Trials Inference With CARE

Statistics in Medicine, Volume 45, Issue 13-14, June 2026.
ABSTRACT We show that cluster‐randomized trials—especially pragmatic designs—often exhibit substantial (but underappreciated in practice) heterogeneity in cluster sizes and structures, distorting inference. Our simulations—reassigning treatment in real data and varying imbalance in synthetic data—show that currently recommended methods (such as ...
Sergey Alexeev, Rachael L. Morton
wiley   +1 more source

Peer review of the pesticide risk assessment of the active substance pyrimethanil

The conclusions of the European Food Safety Authority (EFSA) following the peer review of the initial risk assessments carried out by the competent authorities of the rapporteur Member State Czech Republic and co‐rapporteur Member State Austria for the ...
Dimitra Kardassi, Renata Leuschner, Angelo Colagiorgi, Alessio Ippolito, Miguel Santos, Vincenzo Padricello, Maria Arena, Rachel Sharp, Laura Villamar‐Bouza, Juan Manuel Parra Morte, Ileana Miron, Manuela Tiramani, European Food Safety Authority (EFSA), Sofia Batista Leite, Andrea Terron, Gabriella Fait, Roberto Lava, Giorgia Vianello, Andrea Mioč, Aude Kienzler, Laura Padovani, Simone Rizzuto, Anna Federica Castoldi, Anamarija Romac, Oriol Magrans, Samira Jarrah, Chloe De Lentdecker, Iris Mangas, Arianna Chiusolo, Martina Panzarea, Varvara Gouliarmou, Laia Herrero Nogareda, Fernando Álvarez, Rositsa Serafimova, Agnès Rortais, Marco Binaglia, Tunde Molnar, Mark Egsmose, Galini Mavriou, Domenica Auteri, Christopher Lythgo, Anna Lanzoni, Federica Crivellente, Anne Theobald, Alberto Linguadoca, Franco Ferilli, Csaba Szentes, Isabella De Magistris, Frederique Istace, Katrin Halling, Jochem Louisse, Mathilde Colas, German Giner Santonja   +52 more
core   +1 more source

Feasibility of Crosshole Seismic Tomography for Monitoring In Situ CO2 Mineral Storage in Basalts: A Rock Physics‐ and Seismic Modeling Study

Geochemistry, Geophysics, Geosystems, Volume 27, Issue 6, June 2026.
Abstract In situ CO2 mineral storage is gaining increasing attention as a carbon capture and storage (CCS) technology to reduce anthropogenic CO2 emissions. So far, in situ CO2 mineral storage projects have been monitored predominantly using fluid‐ and isotope geochemical methods.
Jonas Simon Junker, Hansruedi Maurer, Alba Zappone, Sin‐Mei Wu, Anne Obermann   +4 more
wiley   +1 more source

The evolving role of structural biology in pharma: integration of X‐ray crystallography, cryo‐electron microscopy and beyond

Acta Crystallographica Section D, Volume 82, Issue 6, Page 587-602, June 2026.
This review describes how an integrated structural biology platform at Merck Sharp & Dohme LLC, Rahway, New Jersey, USA, combining X‐ray crystallography, cryo‐EM, MicroED and cryo‐ET, enables seamless three‐dimensional insights from molecular to cellular length scales.
Jill E. Chrencik, Hua-Poo Su, Yacob Gomez Llorente, Rachel L. Palte, Daniel J. Klein, Robert P. Hayes, Sadie P. Antine, Guilermo A. Asmar-Rovira, Nicole Bertoletti, Noel J. Byrne, Brittany L. Carroll, Ciro D. Cordeiro, Kaylynn Curfman, James Dutko, Michael J. Eddins, Thierry Fischmann, Barani Govindarajan, Corey W. Hecksel, Thu Ho, Kaspar Hollenstein, Mee Ra Hong, Alan Hruza, Andrii Ishchenko, Maru Jaime-Garza, Matt J. Jaremko, Hayley L. Knox, James Kostas, Harini Krishnamurthy, Ioannis Manolaridis, Cameron L. Noland, Andrea T. Partridge, Sangita B. Patel, Paul Reichert, John C. Reid, Catarina Felisberto-Rodrigues, Chitra A. Shintre, Jennifer M. Shipman, Elakkiya Tamilselvan, Morgan E. Walker, Susanne N. Walker, Renjing Wang, Katharine M. Wright, Tien-Jui Yen, Byung-Kuk Yoo, Sandra B. Gabelli   +44 more
wiley   +1 more source

Improved mesophyll–bundle sheath connectivity is achieved via different mechanisms in C2 vs C4 Alternanthera

New Phytologist, Volume 250, Issue 6, Page 3675-3686, June 2026.
Leaf anatomy and biochemistry of C3, C2, and C4 plants. Summary Connectivity between mesophyll (M) and bundle sheath (BS) cells must improve during the evolution of C4 photosynthesis to facilitate large metabolite fluxes between these cell types, but the trait combinations that enhance M–BS connectivity and the points at which these enhancements occur ...
Hattie R. Roberts, Roxana Khoshravesh, George Rumble, Tamara Hernández‐Verdeja, Marjorie R. Lundgren   +4 more
wiley   +1 more source